{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:14:55Z","timestamp":1783948495157,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Pacific Udall Center","award":["P50 NS062684"],"award-info":[{"award-number":["P50 NS062684"]}]},{"name":"Department of Veterans Affairs Northwest Parkinson\u2019s Disease Research, Education and Clinical Center"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Reduced cortical sensorimotor inhibition is associated with mobility and cognitive impairments in people with Parkinson\u2019s disease (PD) and older adults (OAs). However, there is a lack of clarity regarding the relationships among sensorimotor, cognitive, and mobility impairments. The purpose of this study was to determine how cortical sensorimotor inhibition relates to impairments in mobility and cognition in people with PD and OAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Cortical sensorimotor inhibition was characterized with short-latency afferent inhibition (SAI) in 81 people with PD and 69 OAs. Six inertial sensors recorded single- and dual-task gait and postural sway characteristics during a 2-minute walk and a 1-minute quiet stance. Cognition was assessed across the memory, visuospatial, executive function, attention, and language domains.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>SAI was significantly impaired in the PD compared to the OA group. The PD group preformed significantly worse across all gait and postural sway tasks. In PD, SAI significantly correlated with single-task foot strike angle and stride length variability, sway area, and jerkiness of sway in the coronal and sagittal planes. In OAs, SAI significantly related to single-task gait speed and stride length, dual-task stride length, and immediate recall (memory domain). No relationship among mobility, cognition, and SAI was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Impaired SAI related to slower gait in OA and to increased gait variability and postural sway in people with PD, all of which have been shown to be related to increased fall risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glaa300","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T17:21:14Z","timestamp":1606756874000},"page":"630-637","source":"Crossref","is-referenced-by-count":14,"title":["Relationships Between Sensorimotor Inhibition and Mobility in Older Adults With and Without Parkinson\u2019s Disease"],"prefix":"10.1093","volume":"76","author":[{"given":"Douglas N","family":"Martini","sequence":"first","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, Portland"},{"name":"Department of Kinesiology, University of Massachusetts Amherst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M","family":"Madhyastha","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington School of Medicine, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Grabowski","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington School of Medicine, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Oakley","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Washington School of Medicine, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ching","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Washington School of Medicine, Seattle"},{"name":"Veterans Affairs Puget Sound Health Care System, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus P","family":"Zabetian","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Washington School of Medicine, Seattle"},{"name":"Veterans Affairs Puget Sound Health Care System, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amie","family":"Hiller","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, Portland"},{"name":"Portland Veterans Affairs Health Care System, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, Portland"},{"name":"Portland Veterans Affairs Health Care System, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Biostatistics & Design Program, Oregon Health and Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi A","family":"Lapidus","sequence":"additional","affiliation":[{"name":"Biostatistics & Design Program, Oregon Health and Science University, Portland"},{"name":"School of Public Health, Oregon Health and Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna","family":"Cholerton","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Montine","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, Portland"},{"name":"Portland Veterans Affairs Health Care System, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay B","family":"Horak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, Portland"},{"name":"Portland Veterans Affairs Health Care System, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"2021062916533828900_CIT0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.parkreldis.2016.07.006","article-title":"Pharmacological treatment in Parkinson\u2019s disease: effects on gait","volume":"31","author":"Smulders","year":"2016","journal-title":"Parkinsonism Relat Disord."},{"key":"2021062916533828900_CIT0002","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/mds.26269","article-title":"Levodopa is a double-edged sword for balance and gait in people with Parkinson\u2019s disease","volume":"30","author":"Curtze","year":"2015","journal-title":"Mov Disord."},{"key":"2021062916533828900_CIT0003","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jsr.2008.05.002","article-title":"Self-reported falls and fall-related injuries among persons aged \u2265 65 years\u2013United States, 2006","volume":"39","author":"Stevens","year":"2008","journal-title":"J Safety Res"},{"key":"2021062916533828900_CIT0004","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s004150170047","article-title":"Prospective assessment of falls in Parkinson\u2019s disease","volume":"248","author":"Bloem","year":"2001","journal-title":"J Neurol."},{"key":"2021062916533828900_CIT0005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/mds.20266","article-title":"Prevalence of gait disorders in hospitalized neurological patients","volume":"20","author":"Stolze","year":"2005","journal-title":"Mov Disord."},{"key":"2021062916533828900_CIT0006","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11910-013-0377-9","article-title":"Cholinergic dysfunction in Parkinson\u2019s disease","volume":"13","author":"M\u00fcller","year":"2013","journal-title":"Curr Neurol Neurosci Rep."},{"key":"2021062916533828900_CIT0007","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1468-1331.2009.02900.x","article-title":"Neurotransmission in Parkinson\u2019s disease: beyond dopamine","volume":"17","author":"Barone","year":"2010","journal-title":"Eur J Neurol."},{"key":"2021062916533828900_CIT0008","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.tins.2013.06.003","article-title":"Advances in the pharmacological treatment of Parkinson\u2019s disease: targeting neurotransmitter systems","volume":"36","author":"Brichta","year":"2013","journal-title":"Trends Neurosci."},{"key":"2021062916533828900_CIT0009","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1212\/WNL.0b013e3182a9f558","article-title":"Gait speed in Parkinson disease correlates with cholinergic degeneration","volume":"81","author":"Bohnen","year":"2013","journal-title":"Neurology."},{"issue":"Pt 11","key":"2021062916533828900_CIT0010","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1093\/brain\/awt247","article-title":"Thalamic cholinergic innervation and postural sensory integration function in Parkinson\u2019s disease","volume":"136","author":"M\u00fcller","year":"2013","journal-title":"Brain."},{"key":"2021062916533828900_CIT0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.parkreldis.2019.02.017","article-title":"Overview of the cholinergic contribution to gait, balance and falls in Parkinson\u2019s disease","volume":"63","author":"Morris","year":"2019","journal-title":"Parkinsonism Relat Disord."},{"key":"2021062916533828900_CIT0012","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnagi.2016.00104","article-title":"Attentional control of gait and falls: is cholinergic dysfunction a common substrate in the elderly and Parkinson\u2019s disease?","volume":"8","author":"Pelosin","year":"2016","journal-title":"Front Aging Neurosci."},{"issue":"Pt 9","key":"2021062916533828900_CIT0013","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1093\/brain\/aws207","article-title":"Cholinergic dysfunction contributes to gait disturbance in early Parkinson\u2019s disease","volume":"135","author":"Rochester","year":"2012","journal-title":"Brain."},{"key":"2021062916533828900_CIT0014","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1469-7793.2000.t01-1-00503.x","article-title":"Short latency inhibition of human hand motor cortex by somatosensory input from the hand","volume":"523 Pt 2","author":"Tokimura","year":"2000","journal-title":"J Physiol."},{"key":"2021062916533828900_CIT0015","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1212\/01.wnl.0000204183.26231.23","article-title":"In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias","volume":"66","author":"Di Lazzaro","year":"2006","journal-title":"Neurology."},{"key":"2021062916533828900_CIT0016","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s002210000543","article-title":"Muscarinic receptor blockade has differential effects on the excitability of intracortical circuits in the human motor cortex","volume":"135","author":"Di Lazzaro","year":"2000","journal-title":"Exp Brain Res."},{"issue":"Pt 2","key":"2021062916533828900_CIT0017","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1113\/jphysiol.2004.061747","article-title":"Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans","volume":"564","author":"Di Lazzaro","year":"2005","journal-title":"J Physiol."},{"issue":"Pt 8","key":"2021062916533828900_CIT0018","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/brain\/awg183","article-title":"Short and long latency afferent inhibition in Parkinson\u2019s disease","volume":"126","author":"Sailer","year":"2003","journal-title":"Brain."},{"key":"2021062916533828900_CIT0019","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/jnnp.55.11.1009","article-title":"The dopaminergic response in multiple system atrophy","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"2021062916533828900_CIT0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3233\/JPD-130189","article-title":"Pacific Northwest Udall Center of Excellence Clinical Consortium: study design and baseline cohort characteristics","volume":"3","author":"Cholerton","year":"2013","journal-title":"J Parkinsons Dis."},{"key":"2021062916533828900_CIT0021","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson\u2019s disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov Disord."},{"issue":"Suppl. 1","key":"2021062916533828900_CIT0022","first-page":"007","article-title":"Mobility lab to assess balance and gait with synchronized body-worn sensors","author":"Mancini","year":"2011","journal-title":"J Bioeng Biomed Sci."},{"key":"2021062916533828900_CIT0023","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1017\/S0048577201991279","article-title":"Stimulus modality and Go\/NoGo effects on P3 during parallel visual and auditory continuous performance tasks","volume":"38","author":"Tekok-Kilic","year":"2001","journal-title":"Psychophysiology"},{"key":"2021062916533828900_CIT0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1532-5415.1990.tb01588.x","article-title":"Aging and postural control. A comparison of spontaneous- and induced-sway balance tests","volume":"38","author":"Maki","year":"1990","journal-title":"J Am Geriatr Soc."},{"key":"2021062916533828900_CIT0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1743-0003-9-59","article-title":"ISway: a sensitive, valid and reliable measure of postural control","volume":"9","author":"Mancini","year":"2012","journal-title":"J Neuroeng Rehabil."},{"key":"2021062916533828900_CIT0026","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.parkreldis.2019.06.014","article-title":"Cognitive associations with comprehensive gait and static balance measures in Parkinson\u2019s disease","volume":"69","author":"Morris","year":"2019","journal-title":"Parkinsonism Relat Disord."},{"key":"2021062916533828900_CIT0027","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology."},{"key":"2021062916533828900_CIT0028","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2105\/AJPH.79.3.340","article-title":"Modeling and variable selection in epidemiologic analysis","volume":"79","author":"Greenland","year":"1989","journal-title":"Am J Public Health."},{"key":"2021062916533828900_CIT0029","doi-asserted-by":"crossref","first-page":"026113","DOI":"10.1063\/1.3147408","article-title":"Gait dynamics in Parkinson\u2019s disease: common and distinct behavior among stride length, gait variability, and fractal-like scaling","volume":"19","author":"Hausdorff","year":"2009","journal-title":"Chaos."},{"key":"2021062916533828900_CIT0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0268-0033(01)00035-3","article-title":"The biomechanics and motor control of gait in Parkinson disease","volume":"16","author":"Morris","year":"2001","journal-title":"Clin Biomech (Bristol, Avon)."},{"key":"2021062916533828900_CIT0031","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1080\/09638280701829938","article-title":"Dysfunctional turning in Parkinson\u2019s disease","volume":"30","author":"Stack","year":"2008","journal-title":"Disabil Rehabil."},{"key":"2021062916533828900_CIT0032","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1460-9568.2005.04298.x","article-title":"Dual tasking, gait rhythmicity, and Parkinson\u2019s disease: which aspects of gait are attention demanding?","volume":"22","author":"Yogev","year":"2005","journal-title":"Eur J Neurosci."},{"key":"2021062916533828900_CIT0033","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/0891988702250580","article-title":"Effects of cognitive challenge on gait variability in patients with Parkinson\u2019s disease","volume":"16","author":"Hausdorff","year":"2003","journal-title":"J Geriatr Psychiatry Neurol."},{"key":"2021062916533828900_CIT0034","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/NRE-151236","article-title":"Continuous monitoring of turning in Parkinson\u2019s disease: rehabilitation potential","volume":"37","author":"Mancini","year":"2015","journal-title":"NeuroRehabilitation."},{"key":"2021062916533828900_CIT0035","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1152\/jn.1996.75.6.2380","article-title":"Effects of dopamine on postural control in parkinsonian subjects: scaling, set, and tone","volume":"75","author":"Horak","year":"1996","journal-title":"J Neurophysiol."},{"key":"2021062916533828900_CIT0036","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2522\/ptj.20150580","article-title":"Balance and gait represent independent domains of mobility in Parkinson disease","volume":"96","author":"Horak","year":"2016","journal-title":"Phys Ther."},{"key":"2021062916533828900_CIT0037","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.parkreldis.2011.05.010","article-title":"Trunk accelerometry reveals postural instability in untreated Parkinson\u2019s disease","volume":"17","author":"Mancini","year":"2011","journal-title":"Parkinsonism Relat Disord."},{"key":"2021062916533828900_CIT0038","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroimage.2017.02.073","article-title":"Dopamine depletion impairs gait automaticity by altering cortico-striatal and cerebellar processing in Parkinson\u2019s disease","volume":"152","author":"Gilat","year":"2017","journal-title":"Neuroimage."},{"key":"2021062916533828900_CIT0039","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.apmr.2011.08.026","article-title":"Dual-task complexity affects gait in people with mild cognitive impairment: the interplay between gait variability, dual tasking, and risk of falls","volume":"93","author":"Montero-Odasso","year":"2012","journal-title":"Arch Phys Med Rehabil."},{"key":"2021062916533828900_CIT0040","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.gaitpost.2011.08.014","article-title":"Gait assessment in mild cognitive impairment and Alzheimer\u2019s disease: the effect of dual-task challenges across the cognitive spectrum","volume":"35","author":"Muir","year":"2012","journal-title":"Gait Posture."},{"key":"2021062916533828900_CIT0041","doi-asserted-by":"crossref","first-page":"133679","DOI":"10.1016\/j.neulet.2018.06.048","article-title":"Short-afferent inhibition and cognitive impairment in Parkinson\u2019s disease: a quantitative review and challenges","volume":"719","author":"Martin-Rodriguez","year":"2020","journal-title":"Neurosci Lett."}],"container-title":["The Journals of Gerontology: Series A"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glaa300\/35558723\/glaa300.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/76\/4\/630\/38838258\/glaa300.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/76\/4\/630\/38838258\/glaa300.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T16:54:12Z","timestamp":1624985652000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/76\/4\/630\/6012762"}},"subtitle":[],"editor":[{"given":"Jay","family":"Magaziner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2021,3,31]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glaa300","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2020,11,30]]}}}