{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:57:33Z","timestamp":1791932253204,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously assessed the inclusion of S100B blood determination into clinical decision rules for mild traumatic brain injury (mTBI) management in the Emergency Department (ED) of Clermont-Ferrand Hospital. At the 0.10 \u00b5g\/L threshold, S100B reduced the use of cranial computed tomography (CCT) scan in adults by at least 30% with a ~100% sensitivity. Older patients had higher serum S100B values, resulting in lower specificity (18.7%) and decreased CCT reduction. We conducted this study to confirm the age effect on S100B concentrations, and to propose new decisional thresholds for older patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1172 mTBI patients aged 65 and over were included. They were divided into 3 age groups: 65\u201379, 80\u201389, and \u2265 90 years old. S100B\u2019s performance to identify intracranial lesions (sensitivity [SE] and specificity [SP]) was assessed using the routine 0.10 \u00b5g\/L threshold and also other more efficient thresholds established for each age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>S100B concentration medians were 0.18, 0.26, and 0.32 \u00b5g\/L for the 65\u201379, 80\u201389, and \u2265 90 years old age groups, respectively (p &amp;lt; .001). The most efficient thresholds were 0.11 \u00b5g\/L for the 65\u201379 age group and 0.15 \u00b5g\/L for the other groups. At these new thresholds, SP was respectively 28.4%, 34.3%, and 20.5% for each age group versus 24.9%, 18.2%, and 10.5% at the 0.10 \u00b5g\/L threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjustment of the S100B threshold is necessary in older patients\u2019 management. An increased threshold of 0.15 \u00b5g\/L is particularly interesting for patients \u2265 80 years old, allowing a significant increase of CCT scan reduction (29.3%).<\/jats:p><\/jats:sec>","DOI":"10.1093\/gerona\/glab055","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:04:09Z","timestamp":1614643449000},"page":"1471-1479","source":"Crossref","is-referenced-by-count":37,"title":["Predictive Performance of Blood S100B in the Management of Patients Over 65 Years Old With Mild Traumatic Brain Injury"],"prefix":"10.1093","volume":"76","author":[{"given":"Charlotte","family":"Oris","sequence":"first","affiliation":[{"name":"University Hospital, Biochemistry and Molecular Genetic Department, Clermont-Ferrand, France"},{"name":"Clermont Auvergne University, CNRS 6293, INSERM 1103, GReD, Clermont-Ferrand, 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