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Besides we evaluated the effects of a prebiotic (\u03b2-glucan isolated from Saccharomyces cerevisiae) in preventing vascular dysfunction. The sample comprised young (sham and induced to periodontal disease) and middle-aged rats (sham, periodontal disease, sham-treated and periodontal disease-treated), at 12 and 57 weeks, respectively. The treated-groups received daily doses of \u03b2-glucan (50 mg\/kg) orally (gavage) for 4 weeks, and periodontal disease was induced in the last 2 weeks by ligature. A myograph system assessed vascular reactivity. The expression of endothelial nitric oxide synthase (eNOS), cyclooxygenase 1 (COX-1), COX-2, p47phox, gp91phox, NF-KB p65, p53, p21, and p16 was quantified by western blotting. Serum hydroperoxide production was measured by the ferrous oxidation\u2013xylenol orange (FOX-2) assay method. Interleukin-1 beta (IL-1\u03b2), IL-10, and tumor necrosis factor-alpha (TNF-\u03b1) levels were evaluated by spectroscopic ultraviolet-visible analysis. Periodontal disease in middle-aged rats was associated with reduced acetylcholine-induced relaxations of coronary artery rings affecting the endothelium-dependent hyperpolarization- and the nitric oxide-mediated relaxations. The endothelial dysfunction was related to eNOS downregulation, pronounced impairment of the EDH-mediated relaxation, increased IL-1\u03b2 and TNF-\u03b1 proinflammatory cytokines, and also upregulation of NADPH oxidase and COXs, starting accumulate aging markers such as p53\/p21 and the p16. Treatment with \u03b2-glucan effectively reduced bone loss in periodontal disease and delayed endothelial dysfunction in the coronary artery. Our data show that yeast \u03b2-glucan ingestion prevented oxidative stress and synthesis of proinflammatory marker and prevented eNOS reduction induced by periodontal disease in middle-aged rats. These results suggest that \u03b2-glucan has a beneficial effect on the coronary vascular bed.<\/jats:p>","DOI":"10.1093\/gerona\/glab066","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T17:55:06Z","timestamp":1615139706000},"page":"1398-1406","source":"Crossref","is-referenced-by-count":6,"title":["Experimental Periodontal Disease Triggers Coronary Endothelial Dysfunction in Middle-Aged Rats: Preventive Effect of a Prebiotic \u03b2-Glucan"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-1740","authenticated-orcid":false,"given":"Grazielle Caroline","family":"Silva","sequence":"first","affiliation":[{"name":"Faculty of Health, Centro Universit\u00e1rio de Lavras (UNILAVRAS), Lavras, Minas Gerais, Brazil"},{"name":"Department of Health Sciences, Universidade Federal de Lavras (UFLA), Lavras, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo 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