{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:01:41Z","timestamp":1793314901129,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Robert N.\u00a0Butler Columbia Aging Center"},{"DOI":"10.13039\/100000935","name":"Russel Sage Foundation","doi-asserted-by":"crossref","award":["1810-08987"],"award-info":[{"award-number":["1810-08987"]}],"id":[{"id":"10.13039\/100000935","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003986","name":"Jacobs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["5T32MH013043"],"award-info":[{"award-number":["5T32MH013043"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loneliness and social isolation are emerging public health challenges for aging populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We followed N = 11 302 U.S. Health and Retirement Study participants aged 50\u201395 from 2006 to 2014 to measure persistence of experiences of loneliness and exposure to social isolation. We tested associations of longitudinal loneliness and social isolation phenotypes with disability, morbidity, mortality, and biological aging through 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up, 18% of older adults met criteria for loneliness, with 6% meeting criteria at 2 or more follow-up assessments. For social isolation, these fractions were 21% and 8%. Health and Retirement Study participants who experienced loneliness and were exposed to social isolation were at increased risk for disease, disability, and mortality. Those experiencing persistent loneliness were at a 57% increased hazard of mortality compared to those who never experienced loneliness. For social isolation, the increase was 28%. Effect sizes were somewhat larger for counts of prevalent activity limitations and somewhat smaller for counts of prevalent chronic diseases. Covariate adjustment for socioeconomic and psychological risks attenuated but did not fully explain associations. Older adults who experienced loneliness and were exposed to social isolation also exhibited physiological indications of advanced biological aging (Cohen\u2019s d for persistent loneliness and social isolation = 0.26 and 0.21, respectively). For loneliness, but not social isolation, persistence was associated with increased risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Deficits in social connectedness prevalent in a national sample of U.S. older adults were associated with morbidity, disability, and mortality and with more advanced biological aging. Bolstering social connectedness to interrupt experiences of loneliness may promote healthy aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glab128","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T13:50:06Z","timestamp":1620481806000},"page":"1997-2006","source":"Crossref","is-referenced-by-count":112,"title":["Associations of Loneliness and Social Isolation With Health Span and Life Span in the U.S. Health and Retirement Study"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-0665","authenticated-orcid":false,"given":"Christopher L","family":"Crowe","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA"},{"name":"Psychiatric Epidemiology Training Program, Columbia University Mailman School of Public Health, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-9049","authenticated-orcid":false,"given":"Benjamin W","family":"Domingue","sequence":"additional","affiliation":[{"name":"Stanford Graduate School of Education, Stanford University, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria H","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA"},{"name":"Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M","family":"Keyes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA"},{"name":"Psychiatric Epidemiology Training Program, Columbia University Mailman School of Public Health, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayoon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-2212","authenticated-orcid":false,"given":"Daniel W","family":"Belsky","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA"},{"name":"Robert N. 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