{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:48:33Z","timestamp":1780105713519,"version":"3.54.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23AG049106"],"award-info":[{"award-number":["K23AG049106"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG021487"],"award-info":[{"award-number":["R01AG021487"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AG030481"],"award-info":[{"award-number":["R37AG030481"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG033903"],"award-info":[{"award-number":["R01AG033903"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG043538"],"award-info":[{"award-number":["R01AG043538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG048511"],"award-info":[{"award-number":["R01AG048511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG060756"],"award-info":[{"award-number":["R01AG060756"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2K24AG069080-06"],"award-info":[{"award-number":["2K24AG069080-06"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30DK092949-09"],"award-info":[{"award-number":["5P30DK092949-09"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Limited research has been conducted to risk stratify older adults with diabetes. Our objective was to reexamine the 2005\u20132006 classification systems in participants who are now 5 years older.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We examined a subsample of 884 community-residing older adults with the diagnosis of diabetes from the National Social Life, Health, and Aging Project. The primary objective was to utilize a latent class analysis (LCA) to fit a model to 11 comorbidities, comparing the 2010\u20132011 LCA model to that of 2005\u20132006. The secondary objective was to evaluate the association of the identified classes with frailty, disability, and 5-year mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Both 2005\u20132006 LCA and the 2010\u20132011 LCA model fit 3 similar comorbidity profiles: Class 1 with the lowest rates of nearly all comorbidities, Class 2 had highest rates of obesity, hypertension, arthritis, and incontinence, and Class 3 had the higher rates of myocardial infarctions, congestive heart failure, and stroke. When compared to the healthier Class 1 (class probability = 0.67), participants with a comorbidity profile with more prevalent cardiovascular conditions (Class 3; 0.09) were at higher risk of frailty and mortality, but not disability; whereas participants with a comorbidity profile with more prevalent geriatric syndrome conditions (Class 2; 0.24) were at higher risk of frailty and disability, but not mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We reconfirmed 3 latent classes with distinct comorbidity profiles among older adults with diabetes. However, the complex relationships between comorbidity classes with frailty, disability, and mortality will likely require revision of the current rationale for stratified goal setting and treatment selection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glab141","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:40:48Z","timestamp":1621345248000},"page":"2071-2079","source":"Crossref","is-referenced-by-count":19,"title":["Reexamining the Classification of Older Adults With Diabetes by Comorbidities and Exploring Relationships With Frailty, Disability, and 5-year Mortality"],"prefix":"10.1093","volume":"76","author":[{"given":"Vania","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Academic Internal Medicine and Geriatrics, University of Illinois at Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Philip","family":"Schumm","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Huisingh-Scheetz","sequence":"additional","affiliation":[{"name":"Section of Geriatrics and Palliative Medicine, University of Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elbert S","family":"Huang","sequence":"additional","affiliation":[{"name":"Section of General Internal Medicine, University of Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"2021101317535692700_CIT0001","volume-title":"The Population 65 Years and Older in the United States: 2016","author":"Roberts","year":"2018"},{"issue":"10","key":"2021101317535692700_CIT0002","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/jama.2015.10029","article-title":"Prevalence of and trends in diabetes among adults in the united states, 1988\u20132012","volume":"314","author":"Menke","year":"2015","journal-title":"JAMA"},{"key":"2021101317535692700_CIT0003","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.2337\/dc12-1801","article-title":"Diabetes in older adults","volume":"35","author":"Kirkman","year":"2012","journal-title":"Diabetes Care"},{"key":"2021101317535692700_CIT0004","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","article-title":"Glucose control and vascular complications in veterans with type 2 diabetes","volume":"360","author":"Duckworth","year":"2009","journal-title":"N Engl J Med"},{"issue":"11","key":"2021101317535692700_CIT0005","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1111\/jgs.12513","article-title":"Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002\u20132012 literature review","volume":"61","author":"Moreno","year":"2013","journal-title":"J Am Geriatr Soc"},{"key":"2021101317535692700_CIT0006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1262-3636(11)70962-4","article-title":"European diabetes working party for older people 2011 clinical guidelines for type 2 diabetes mellitus. 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