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Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44\u201365 years at baseline with up to 30 years of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Hearing was assessed in late life (2016\u20132017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure \u2265140 mmHg, diastolic blood pressure \u226590 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987\u20131989 and 1996\u20131998. Late-life hypertension was defined in 2016\u20132017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = \u22120.66 points, 95% CI: \u22121.14, \u22120.17) but not with audiometric hearing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glab153","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T02:06:53Z","timestamp":1622167613000},"page":"640-646","source":"Crossref","is-referenced-by-count":10,"title":["Longitudinal Blood Pressure Patterns From Mid- to Late Life and Late-Life Hearing Loss in the Atherosclerosis Risk in Communities Study"],"prefix":"10.1093","volume":"77","author":[{"given":"James","family":"Ting","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"},{"name":"Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, 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