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However, the longitudinal relationship between sleep and delirium remains unclear. This study assessed the associations of poor sleep burden, and its trajectory, with delirium risk during hospitalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>About 321 818 participants from the UK Biobank (mean age 58 \u00b1 8 years [SD]; range 37\u201374 years) reported (2006\u20132010) sleep traits (sleep duration, excessive daytime sleepiness, insomnia-type complaints, napping, and chronotype\u2014a closely related circadian measure for sleep timing), aggregated into a sleep burden score (0\u20139). New-onset delirium (n = 4 775) was obtained from hospitalization records during a 12-year median follow-up. About 42 291 (mean age 64 \u00b1 8 years; range 44\u201383 years) had repeat sleep assessment on average 8 years after their first.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the baseline cohort, Cox proportional hazards models showed that moderate (aggregate scores = 4\u20135) and severe (scores = 6\u20139) poor sleep burden groups were 18% (hazard ratio = 1.18 [95% confidence interval: 1.08\u20131.28], p &amp;lt; .001) and 57% (1.57 [1.38\u20131.80], p &amp;lt; .001), more likely to develop delirium, respectively. The latter risk magnitude is equivalent to 2 additional cardiovascular risks. These findings appeared robust when restricted to postoperative delirium and after exclusion of underlying dementia. Higher sleep burden was also associated with delirium in the follow-up cohort. Worsening sleep burden (score increase \u22652 vs no change) further increased the risk for delirium (1.79 [1.23\u20132.62], p = .002) independent of their baseline sleep score and time lag. The risk was highest in those younger than 65 years at baseline (p for interaction &amp;lt;.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Poor sleep burden and worsening trajectory were associated with increased risk for delirium; promotion of sleep health may be important for those at higher risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glab272","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T16:12:05Z","timestamp":1632499925000},"page":"507-516","source":"Crossref","is-referenced-by-count":45,"title":["Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization"],"prefix":"10.1093","volume":"77","author":[{"given":"Ma Cherrysse","family":"Ulsa","sequence":"first","affiliation":[{"name":"Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham 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