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It is unknown whether perceived fatigability, self-reported fatigue anchored to activity intensity and duration, is independently associated with life-space.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assessed this cross-sectionally in Visit 4 (2014\u20132016) of the Osteoporotic Fractures in Men Study (MrOS; N = 1 672, Age: Mean = 84.2 \u00b1 4.0 years). The Pittsburgh Fatigability Scale (PFS, range: 0\u201350; higher = greater fatigability) measured physical (Mean = 16.1 \u00b1 9.4) and mental fatigability (Mean = 7.5 \u00b1 7.9). Life Space Assessment scores incorporated level, frequency, and assistance used for life-space mobility (range: 0\u2013120, higher = greater life-space mobility; life-space constriction: inability to leave neighborhood without assistance). Separate multiple linear and logistic regressions for physical and mental fatigability were sequentially adjusted for demographic, health\/lifestyle, and performance measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean life-space mobility score was 84.6 \u00b1 21.8, and 18% (n = 296) of men had life-space constriction. Higher physical and mental fatigability were both associated with lower life-space mobility in models adjusted for health and lifestyle factors (Physical PFS: B = \u22122.37, 95% confidence interval [CI]: [\u22123.39, \u22121.35]; Mental PFS: B = \u22121.79, 95% CI: [\u22122.73, \u22120.84]). Men with higher fatigability also had increased risk of life-space constriction (Physical PFS: OR = 1.59, 95% CI: [1.32, 1.92]; Mental PFS: OR = 1.25, 95% CI: [1.08, 1.46]). Associations were larger in magnitude for physical versus mental fatigability. Adjusting for physical performance measures more strongly attenuated associations for physical compared to mental fatigability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Fatigability is linked with real-world mobility in older men, independent of their physical health. This association may be driven by separate physical and cognitive mechanisms worth examining further in longitudinal studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glab286","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T11:30:32Z","timestamp":1635679832000},"page":"2329-2335","source":"Crossref","is-referenced-by-count":13,"title":["Life-space Mobility in Older Men: The Role of Perceived Physical and Mental Fatigability"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-6357","authenticated-orcid":false,"given":"Kyle D","family":"Moored","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health , Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L","family":"Rosso","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh 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