{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:25:46Z","timestamp":1774355146348,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang University Education Foundation Global Partnership Fund"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA U01AG009740"],"award-info":[{"award-number":["NIA U01AG009740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48\u20132.72; HR of each SD increment: 1.21, 95% CI: 1.10\u20131.32; p-trend &amp;lt; .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03\u20131.23) and was more pronounced for that closer to diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our prospective study suggested that greater BWV may be a novel risk factor for dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glab372","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T05:49:49Z","timestamp":1639547389000},"page":"2116-2122","source":"Crossref","is-referenced-by-count":7,"title":["Association of Long-Term Body Weight Variability With Dementia: A Prospective Study"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-7811","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health, Zhejiang University School of Medicine , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health, Zhejiang University School of Medicine , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-9957","authenticated-orcid":false,"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-118X","authenticated-orcid":false,"given":"John S","family":"Ji","sequence":"additional","affiliation":[{"name":"Vanke School of Public Health, Tsinghua University , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Public Health, Zhejiang University School of Medicine , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Xu","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University , Tianjin , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangmin","family":"Zuo","sequence":"additional","affiliation":[{"name":"School of Public Health, Zhejiang University School of Medicine , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Lv","sequence":"additional","affiliation":[{"name":"Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health, Peking University Institute of Mental Health (Sixth Hospital) , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-3147","authenticated-orcid":false,"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, School of Life Sciences, Fudan University , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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