{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:16:39Z","timestamp":1775589399961,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Community\u2019s FP7","award":["602461"],"award-info":[{"award-number":["602461"]}]},{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Frailty is a multietiological geriatric syndrome of run-down physical reserves with high vulnerability to stressors. Transitions between physical robustness and frailty often occur in the context of medical interventions. Studies suggest that neurological disorders contribute to faster progression of frailty. In a previous cross-sectional study we found altered functional connectivity of supplementary motor area (SMA) in (pre)frail compared to robust patients. We analyzed functional connectivity of the SMA and presupplementary motor area (pre-SMA) in patients with postoperative transitions between physical robustness and stages of frailty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated 120 cognitively healthy patients (49.2% robust, 47.5% prefrail, 3.3% frail, 37.5% female, median age 71 [65\u201387] years) undergoing elective surgery from the BioCog project, a multicentric prospective cohort study on postoperative delirium and cognitive dysfunction. Assessments took place 14 days before and 3 months after surgery, comprising assessments of a modified frailty phenotype according to Fried and resting-state functional magnetic resonance imaging at 3 T. The associations between functional connectivity of the SMA and pre-SMA networks, preoperative frailty stages, and postoperative transitions were examined using mixed linear effects models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nineteen patients showed physical improvement after surgery, 24 patients progressed to (pre)frailty and in 77 patients no transition was observed. At follow-up, 57 (47.5%) patients were robust, 52 (43.3%) prefrail, and 11 (9.2%) frail. Lower functional connectivity in the pre-SMA network was associated with more unfavorable postoperative transition types. An exploratory analysis suggested that the association was restricted to patients who were prefrail at baseline. There was no association of transition type with SMA functional connectivity in the primary analysis. In an exploratory analysis, transition from prefrailty to robustness was associated with higher functional connectivity and progression in robust patients was associated with higher SMA network segregation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings implicate that dysfunctions of cortical networks involved in higher cognitive control of motion are associated with postoperative transitions between frailty stages. The pre-SMA may be a target for neurofeedback or brain stimulation in approaches to prevent frailty.<\/jats:p>\n                  <jats:p>Clinical Trials Registration Number: NCT02265263<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glac012","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T14:55:12Z","timestamp":1642517712000},"page":"2464-2473","source":"Crossref","is-referenced-by-count":7,"title":["Functional Connectivity of the Supplementary and Presupplementary Motor Areas in Postoperative Transition Between Stages of Frailty"],"prefix":"10.1093","volume":"77","author":[{"given":"Florian","family":"Lammers-Lietz","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health , Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Zacharias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health , Berlin , Germany"},{"name":"Pharmaimage Biomarker Solutions GmbH , Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"M\u00f6rgeli","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health , Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia D","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health , Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Winterer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health , Berlin , Germany"},{"name":"Pharmaimage Biomarker Solutions GmbH , Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"issue":"3","key":"2022122916560931100_CIT0001","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"2022122916560931100_CIT0002","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/ageing\/afy110","article-title":"The prevalence of frailty and its association with clinical outcomes in general surgery: a systematic review and meta-analysis","volume":"47","author":"Hewitt","year":"2018","journal-title":"Age Ageing"},{"issue":"8","key":"2022122916560931100_CIT0003","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/bjs.11148","article-title":"Age of patients undergoing surgery","volume":"106","author":"Fowler","year":"2019","journal-title":"Br J Surg"},{"issue":"10","key":"2022122916560931100_CIT0004","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1111\/jgs.13657","article-title":"Changes in frailty after kidney transplantation","volume":"63","author":"McAdams-DeMarco","year":"2015","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"2022122916560931100_CIT0005","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.healun.2019.03.006","article-title":"Frailty trajectories in adult lung transplantation: a cohort study","volume":"38","author":"Venado","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"2022122916560931100_CIT0006","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s12603-019-1186-x","article-title":"Association between hospitalization and change of frailty status in the GAZEL cohort","volume":"23","author":"Landr\u00e9","year":"2019","journal-title":"J Nutr Health Aging"},{"issue":"10","key":"2022122916560931100_CIT0007","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1007\/s00268-020-05619-7","article-title":"Transition in frailty state among elderly patients after vascular surgery","volume":"44","author":"Banning","year":"2020","journal-title":"World J Surg"},{"issue":"6","key":"2022122916560931100_CIT0008","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00423-020-01936-6","article-title":"Transitions in frailty state after kidney transplantation","volume":"405","author":"Quint","year":"2020","journal-title":"Langenbecks Arch Surg"},{"issue":"8","key":"2022122916560931100_CIT0009","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1532-5415.2012.04054.x","article-title":"Prevalence of frailty in community-dwelling older persons: a systematic review","volume":"60","author":"Collard","year":"2012","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"2022122916560931100_CIT0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/jamasurg.2019.5474","article-title":"Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial","volume":"155","author":"Carli","year":"2020","journal-title":"JAMA Surg"},{"issue":"4","key":"2022122916560931100_CIT0011","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jamda.2013.12.002","article-title":"Transitions in frailty states among community-living older adults and their associated factors","volume":"15","author":"Lee","year":"2014","journal-title":"J Am Med Dir Assoc"},{"key":"2022122916560931100_CIT0012","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.annepidem.2019.03.008","article-title":"Factors associated with changes of the frailty status after age 70: findings in the MAPT study","volume":"34","author":"Herr","year":"2019","journal-title":"Ann Epidemiol"},{"issue":"22","key":"2022122916560931100_CIT0013","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1212\/WNL.0b013e318294b462","article-title":"Association of brain pathology with the progression of frailty in older adults","volume":"80","author":"Buchman","year":"2013","journal-title":"Neurology"},{"issue":"12","key":"2022122916560931100_CIT0014","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/gerona\/glu117","article-title":"Brain pathology contributes to simultaneous change in physical frailty and cognition in old age","volume":"69","author":"Buchman Aron","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2022122916560931100_CIT0015","doi-asserted-by":"crossref","first-page":"e361","DOI":"10.1093\/gerona\/glaa296","article-title":"Biological and neuroimaging markers as predictors of 5-year incident frailty in older adults: a secondary analysis of the MAPT study","volume":"76","author":"Lu","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"9","key":"2022122916560931100_CIT0016","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1089\/brain.2014.0262","article-title":"Resting-state functional connectivity modulation and sustained changes after real-time functional magnetic resonance imaging neurofeedback training in depression","volume":"4","author":"Yuan","year":"2014","journal-title":"Brain Connect"},{"issue":"1","key":"2022122916560931100_CIT0017","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neurobiolaging.2014.08.016","article-title":"Exercise alters resting-state functional connectivity of motor circuits in Parkinsonian rats","volume":"36","author":"Wang","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"9","key":"2022122916560931100_CIT0018","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1177\/0271678X19874338","article-title":"Normalization of reduced functional connectivity after revascularization of asymptomatic carotid stenosis","volume":"40","author":"Quandt","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"2022122916560931100_CIT0019","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.neuroimage.2009.10.016","article-title":"Defining functional SMA and pre-SMA subregions in human MFC using resting state fMRI: functional connectivity-based parcellation method","volume":"49","author":"Kim","year":"2010","journal-title":"Neuroimage"},{"issue":"1","key":"2022122916560931100_CIT0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/cercor\/bhr088","article-title":"Resting-state functional connectivity of the medial superior frontal cortex","volume":"22","author":"Zhang","year":"2012","journal-title":"Cereb Cortex"},{"issue":"12","key":"2022122916560931100_CIT0021","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/gerona\/glz297","article-title":"Functional connectivity of the supplementary motor network is associated with Fried\u2019s modified frailty score in older adults","volume":"75","author":"Lammers","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2022122916560931100_CIT0022","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fmed.2020.00322","article-title":"Functional connectivity disruption in frail older adults without global cognitive deficits","volume":"7","author":"Su\u00e1rez-M\u00e9ndez","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"2022122916560931100_CIT0023","doi-asserted-by":"crossref","first-page":"609043","DOI":"10.3389\/fnagi.2021.609043","article-title":"Ongoing oscillatory electrophysiological alterations in frail older adults: a MEG study","volume":"13","author":"Su\u00e1rez-M\u00e9ndez","year":"2021","journal-title":"Front Aging Neurosci"},{"issue":"10","key":"2022122916560931100_CIT0024","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/j.1532-5415.2012.04145.x","article-title":"Mobility stress test approach to predicting frailty, disability, and mortality in high-functioning older adults","volume":"60","author":"Verghese","year":"2012","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"2022122916560931100_CIT0025","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/gerona\/glaa191","article-title":"Frailty and prodromal Parkinson\u2019s disease: results from the HELIAD study","volume":"76","author":"Ntanasi","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"2022122916560931100_CIT0026","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12877-017-0509-1","article-title":"Frailty assessment in older adults using upper-extremity function: index development","volume":"17","author":"Toosizadeh","year":"2017","journal-title":"BMC Geriatr"},{"issue":"10","key":"2022122916560931100_CIT0027","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/ggi.14015","article-title":"Oral hypofunction and its association with frailty in community-dwelling older people","volume":"20","author":"Shimazaki","year":"2020","journal-title":"Geriatr Gerontol Int"},{"key":"2022122916560931100_CIT0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroimage.2014.12.023","article-title":"Associations between age, motor function, and resting state sensorimotor network connectivity in healthy older adults","volume":"108","author":"Seidler","year":"2015","journal-title":"Neuroimage"},{"issue":"1","key":"2022122916560931100_CIT0029","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/cercor\/bhu165","article-title":"Functional brain activation associated with inhibitory control deficits in older adults","volume":"26","author":"Coxon","year":"2016","journal-title":"Cereb Cortex"},{"issue":"4","key":"2022122916560931100_CIT0030","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s11682-016-9569-7","article-title":"Motor sequence learning in the elderly: differential activity patterns as a function of hand modality","volume":"11","author":"Eudave","year":"2017","journal-title":"Brain Imaging Behav"},{"issue":"12","key":"2022122916560931100_CIT0031","doi-asserted-by":"crossref","first-page":"E966","DOI":"10.3390\/brainsci10120966","article-title":"Age-related decline of sensorimotor integration influences resting-state functional brain connectivity","volume":"10","author":"Yoshimura","year":"2020","journal-title":"Brain Sci"},{"key":"2022122916560931100_CIT0032","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cortex.2014.08.004","article-title":"A dissociation between stopping and switching actions following a lesion of the pre-supplementary motor area","volume":"63","author":"Roberts","year":"2015","journal-title":"Cortex"},{"key":"2022122916560931100_CIT0033","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3389\/fneur.2015.00209","article-title":"Supplementary motor complex and disturbed motor control\u2014a retrospective clinical and lesion analysis of patients after anterior cerebral artery stroke","volume":"6","author":"Brugger","year":"2015","journal-title":"Front Neurol"},{"issue":"4","key":"2022122916560931100_CIT0034","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s11682-019-00061-3","article-title":"Coordinate based meta-analysis of motor functional imaging in Parkinson\u2019s: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation","volume":"14","author":"Xing","year":"2020","journal-title":"Brain Imaging Behav"},{"issue":"suppl 2","key":"2022122916560931100_CIT0035","doi-asserted-by":"crossref","first-page":"T155","DOI":"10.1016\/j.neuroimage.2007.03.034","article-title":"The role of the pre-supplementary motor area in the control of action","volume":"36","author":"Nachev","year":"2007","journal-title":"Neuroimage"},{"key":"2022122916560931100_CIT0036","doi-asserted-by":"crossref","first-page":"134837","DOI":"10.1016\/j.neulet.2020.134837","article-title":"Preliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson\u2019s disease","volume":"724","author":"Hano\u011flu","year":"2020","journal-title":"Neurosci Lett"},{"issue":"2","key":"2022122916560931100_CIT0037","doi-asserted-by":"crossref","first-page":"fcaa147","DOI":"10.1093\/braincomms\/fcaa147","article-title":"Low-frequency transcranial stimulation of pre-supplementary motor area alleviates levodopa-induced dyskinesia in Parkinson\u2019s disease: a randomized cross-over trial","volume":"2","author":"Lohse","year":"2020","journal-title":"Brain Commun"},{"issue":"6","key":"2022122916560931100_CIT0038","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.brs.2016.08.003","article-title":"A double-blind, sham-controlled pilot trial of pre-supplementary motor area (pre-SMA) 1\u2009Hz rTMS to treat essential tremor","volume":"9","author":"Badran","year":"2016","journal-title":"Brain Stimul"},{"issue":"1","key":"2022122916560931100_CIT0039","doi-asserted-by":"crossref","first-page":"14840","DOI":"10.1038\/s41598-017-13260-z","article-title":"Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"7","author":"Goodwill","year":"2017","journal-title":"Sci Rep"},{"key":"2022122916560931100_CIT0040","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3389\/fnhum.2014.00937","article-title":"Comparison of effects of transcranial magnetic stimulation on primary motor cortex and supplementary motor area in motor skill learning (randomized, cross over study)","volume":"8","author":"Kim","year":"2014","journal-title":"Front Hum Neurosci"},{"issue":"2","key":"2022122916560931100_CIT0041","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brs.2012.03.018","article-title":"Anodal transcranial direct current stimulation (tDCS) over supplementary motor area (SMA) but not pre-SMA promotes short-term visuomotor learning","volume":"6","author":"Vollmann","year":"2013","journal-title":"Brain Stimul"},{"issue":"45","key":"2022122916560931100_CIT0042","doi-asserted-by":"crossref","first-page":"16309","DOI":"10.1523\/JNEUROSCI.3498-11.2011","article-title":"Real-time functional magnetic resonance imaging neurofeedback for treatment of Parkinson\u2019s disease","volume":"31","author":"Subramanian","year":"2011","journal-title":"J Neurosci"},{"issue":"4","key":"2022122916560931100_CIT0043","doi-asserted-by":"crossref","first-page":"045003","DOI":"10.1117\/1.NPh.4.4.045003","article-title":"Neurofeedback-induced facilitation of the supplementary motor area affects postural stability","volume":"4","author":"Fujimoto","year":"2017","journal-title":"Neurophotonics"},{"issue":"4","key":"2022122916560931100_CIT0044","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/gerona\/gls190","article-title":"Using timed up-and-go to identify frail members of the older population","volume":"68","author":"Savva","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"2022122916560931100_CIT0045","doi-asserted-by":"crossref","first-page":"M366","DOI":"10.1093\/gerona\/56.6.M366","article-title":"Screening for undernutrition in geriatric practice: developing the short-form Mini-Nutritional Assessment (MNA-SF)","volume":"56","author":"Rubenstein","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"10","key":"2022122916560931100_CIT0046","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual Life Res"},{"issue":"3","key":"2022122916560931100_CIT0047","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect"},{"issue":"Pt 12","key":"2022122916560931100_CIT0048","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1093\/brain\/awl244","article-title":"Functions of the left superior frontal gyrus in humans: a lesion study","volume":"129","author":"du Boisgueheneuc","year":"2006","journal-title":"Brain"},{"issue":"4","key":"2022122916560931100_CIT0049","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/hbm.22717","article-title":"Functional connectivity associated with gait velocity during walking and walking-while-talking in aging: a resting-state fMRI study","volume":"36","author":"Yuan","year":"2015","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"2022122916560931100_CIT0050","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1161\/01.STR.0000071761.36075.A6","article-title":"Functional neuroimaging studies of motor recovery after stroke in adults: a review","volume":"34","author":"Calautti","year":"2003","journal-title":"Stroke"},{"key":"2022122916560931100_CIT0051","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3389\/fnhum.2019.00468","article-title":"Differential reorganization of SMA subregions after stroke: a subregional level resting-state functional connectivity study","volume":"13","author":"Liu","year":"2019","journal-title":"Front Hum Neurosci"},{"issue":"1","key":"2022122916560931100_CIT0052","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/hbm.10103","article-title":"Brain activations during motor imagery of locomotor-related tasks: a PET study","volume":"19","author":"Malouin","year":"2003","journal-title":"Hum Brain Mapp"},{"key":"2022122916560931100_CIT0053","doi-asserted-by":"crossref","first-page":"117708","DOI":"10.1016\/j.neuroimage.2020.117708","article-title":"Reward modulates cortical representations of action","volume":"228","author":"Adkins","year":"2021","journal-title":"Neuroimage"}],"container-title":["The Journals of Gerontology: Series A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glac012\/42603740\/glac012.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/77\/12\/2464\/48444387\/glac012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/77\/12\/2464\/48444387\/glac012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T17:22:54Z","timestamp":1672334574000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/77\/12\/2464\/6510908"}},"subtitle":[],"editor":[{"given":"Lewis A","family":"Lipsitz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,1,18]]},"published-print":{"date-parts":[[2022,12,29]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glac012","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,1,18]]}}}