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Previously, we provided the first evidence that increased risk of poor health outcomes, as quantified by a frailty index (FI), is associated with an alteration of the central nervous system (CNS) biomechanical response to blood pulsatility. In this study, we explored correlation between 14 biological parameters, the CNS elastance coefficient and FI. We included 60 adults (52\u201392 years) suspected of normal pressure hydrocephalus and presenting with markers of multiple coexisting brain pathologies, including Parkinson disease, Alzheimer disease, and vascular dementia. We showed that the homocysteine (Hcy) level was independently and positively associated with both the FI and the CNS elastance coefficient (adjusted R\u00b2 of 10% and 6%). We also demonstrated that creatinine clearance and folate level were independently associated with Hcy level. Based on previous literature results describing the involvement of Hcy in endothelial dysfunction, glial activation, and neurodegeneration, we discuss how Hcy could contribute to the altered biomechanical response of the CNS and frailty.<\/jats:p>","DOI":"10.1093\/gerona\/glac074","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T18:56:09Z","timestamp":1648234569000},"page":"1335-1343","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Homocysteine, Frailty and Biomechanical Response of the CNS in NPH-Suspected Patients"],"prefix":"10.1093","volume":"77","author":[{"given":"Sophie","family":"Guillotin","sequence":"first","affiliation":[{"name":"Center for Epidemiology and Research in POPulation health (CERPOP), University of Toulouse , Toulouse , France"},{"name":"Poison Control Center, Toulouse-Purpan University Hospital , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Vallet","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lorthois","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9canique des Fluides de Toulouse (IMFT), University of Toulouse , CNRS, Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cestac","sequence":"additional","affiliation":[{"name":"Center for Epidemiology and Research in POPulation health (CERPOP), University of Toulouse , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), University of Toulouse, INSERM, UPS , Toulouse , France"},{"name":"Department of Neurosurgery, Toulouse-Purpan University Hospital , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-9392","authenticated-orcid":false,"given":"Nicolas","family":"Delcourt","sequence":"additional","affiliation":[{"name":"Poison Control Center, Toulouse-Purpan University Hospital , Toulouse , France"},{"name":"Toulouse NeuroImaging Center (ToNIC), University of Toulouse, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"issue":"3","key":"2022070516463851800_CIT0001","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"9868","key":"2022070516463851800_CIT0002","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet."},{"issue":"1","key":"2022070516463851800_CIT0003","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s43587-020-00017-z","article-title":"The physical frailty syndrome as a transition from homeostatic symphony to cacophony","volume":"1","author":"Fried","year":"2021","journal-title":"Nat Aging."},{"issue":"9","key":"2022070516463851800_CIT0004","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/j.1532-5415.2012.04142.x","article-title":"Is frailty a prodromal stage of vascular dementia? 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