{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:20:37Z","timestamp":1787008837168,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["848017004"],"award-info":[{"award-number":["848017004"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["6130.0031"],"award-info":[{"award-number":["6130.0031"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Cohorts of young old in the 21st century","award":["480-10-014"],"award-info":[{"award-number":["480-10-014"]}]},{"name":"Netherlands Consortium Healthy Ageing"},{"DOI":"10.13039\/501100016239","name":"Ministry of Economic Affairs, Agriculture and Innovation","doi-asserted-by":"publisher","award":["KB-15-004-003"],"award-info":[{"award-number":["KB-15-004-003"]}],"id":[{"id":"10.13039\/501100016239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["2005121"],"award-info":[{"award-number":["2005121"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science, Baden-W\u00fcrttemberg, and the German Research Foundation","award":["RO2606\/14-1"],"award-info":[{"award-number":["RO2606\/14-1"]}]},{"name":"Ministry of Science, Baden-W\u00fcrttemberg, and the German Research Foundation","award":["DE2674\/1-1"],"award-info":[{"award-number":["DE2674\/1-1"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["DG XII"],"award-info":[{"award-number":["DG XII"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of the Minister for Health and Children"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Use of fall prevention strategies requires detection of high-risk patients. Our goal was to develop prediction models for falls and recurrent falls in community-dwelling older adults and to improve upon previous models by using a large, pooled sample and by considering a wide range of candidate predictors, including medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Harmonized data from 2 Dutch (LASA, B-PROOF) and 1 German cohort (ActiFE Ulm) of adults aged \u226565 years were used to fit 2 logistic regression models: one for predicting any fall and another for predicting recurrent falls over 1 year. Model generalizability was assessed using internal\u2013external cross-validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data of 5 722 participants were included in the analyses, of whom 1 868 (34.7%) endured at least 1 fall and 702 (13.8%) endured a recurrent fall. Positive predictors for any fall were: educational status, depression, verbal fluency, functional limitations, falls history, and use of antiepileptics and drugs for urinary frequency and incontinence; negative predictors were: body mass index (BMI), grip strength, systolic blood pressure, and smoking. Positive predictors for recurrent falls were: educational status, visual impairment, functional limitations, urinary incontinence, falls history, and use of anti-Parkinson drugs, antihistamines, and drugs for urinary frequency and incontinence; BMI was a negative predictor. The average C-statistic value was 0.65 for the model for any fall and 0.70 for the model for recurrent falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with previous models, the model for recurrent falls performed favorably while the model for any fall performed similarly. Validation and optimization of the models in other populations are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glac080","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T08:31:37Z","timestamp":1649147497000},"page":"1446-1454","source":"Crossref","is-referenced-by-count":20,"title":["Development of the AD\n                    <i>F<\/i>\n                    ICE_IT Models for Predicting Falls and Recurrent Falls in Community-Dwelling Older Adults: Pooled Analyses of European Cohorts With Special Attention to Medication"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-6401","authenticated-orcid":false,"given":"Bob","family":"van de Loo","sequence":"first","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Epidemiology and Data Science , De Boelelaan 1117, Amsterdam , Netherlands"},{"name":"Amsterdam UMC location University of Amsterdam, Internal 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Public Health research institute , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Medlock","sequence":"additional","affiliation":[{"name":"Amsterdam Public Health research institute , Amsterdam , The Netherlands"},{"name":"Amsterdam UMC location University of Amsterdam, Department of Medical Informatics , Meibergdreef 9, Amsterdam , Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Denkinger","sequence":"additional","affiliation":[{"name":"Institute for Geriatric Research, Ulm University at Agaplesion Bethesda Clinic , Ulm , Germany"},{"name":"Geriatric Center Ulm , Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette CPGM","family":"de Groot","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health, Wageningen University , Wageningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose-Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"TILDA, Department of Medical Gerontology, Trinity College , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-3625","authenticated-orcid":false,"given":"Frank","family":"Moriarty","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health, Wageningen University , Wageningen , The Netherlands"},{"name":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-2791","authenticated-orcid":false,"given":"Dietrich","family":"Rothenbacher","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Ulm University , Ulm , 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