{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:36:32Z","timestamp":1793770592758,"version":"4.6.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"name":"Ministry of Health & Welfare","award":["HI16C1118"],"award-info":[{"award-number":["HI16C1118"]}]},{"name":"Medical Research Center Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A5A2031612"],"award-info":[{"award-number":["2021R1A5A2031612"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Republic of Korea","award":["2019S1A5C2A03082727"],"award-info":[{"award-number":["2019S1A5C2A03082727"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Roles for extracellular vesicles (EVs) enriched with micro-RNAs (miRNAs) have been proposed in Alzheimer\u2019s disease (AD) pathogenesis, leading to the discovery of blood miRNAs as AD biomarkers. However, the diagnostic utility of specific miRNAs is not consistent. This study aimed to discover blood miRNAs that are differentially expressed in Korean AD patients, evaluate their clinical performance, and investigate their role in amyloidogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We discovered miRNAs differentially expressed in AD (N = 8) from cognitively normal participants (CN, N = 7) or Parkinson\u2019s disease (PD) patients (N = 8). We evaluated the clinical performance of these miRNAs in plasma of subgroup (N = 99) and in plasma EVs isolated from the total cohort (N = 251). The effects of miRNAs on amyloidogenesis and on the regulation of their target genes were investigated in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 17 upregulated and one downregulated miRNAs in AD (&amp;gt;twofold), miR-122-5p, miR-210-3p, and miR-590-5p were differentially expressed compared with CN or PD. However, the diagnostic performance of the selected plasma or EV miRNAs in total participants were limited (area under the curve &amp;lt; 0.8). Nevertheless, levels of 3 miRNAs in plasma or plasma EVs of participants who were amyloid positron emission tomography (A\u03b2-PET) positive were significantly higher than those from the A\u03b2-PET negative participants (p &amp;lt; .05). The selected miRNAs induced A\u03b2 production (p &amp;lt; .05) through activation of \u03b2-cleavage of amyloid precursor protein (CTF-\u03b2; p &amp;lt; .01), and downregulated their target genes (ADAM metallopeptidase domain 10, Brain-derived neurotrophic factor, and Jagged canonical notch ligand 1; p &amp;lt; .05), which was further supported by pathway enrichment analysis of target genes of the miRNAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, despite of the limited diagnostic utility of selected miRNAs as plasma or plasma EV biomarkers, the discovered miRNAs may play a role in amyloidogenesis during AD onset and progression.<\/jats:p><\/jats:sec>","DOI":"10.1093\/gerona\/glac106","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T15:26:04Z","timestamp":1652109964000},"page":"292-303","source":"Crossref","is-referenced-by-count":9,"title":["Circulating micro-RNAs Differentially Expressed in Korean Alzheimer\u2019s Patients With Brain A\u03b2 Accumulation Activate Amyloidogenesis"],"prefix":"10.1093","volume":"78","author":[{"given":"Sakulrat","family":"Mankhong","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Research Center for Controlling Intercellular Communication, College of Medicine, Inha University , Incheon , Republic of Korea"},{"name":"Program in Biomedical Science and Engineering, Inha University , Incheon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Research Center for Controlling Intercellular Communication, College of Medicine, Inha University , Incheon , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohee","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Research Center for Controlling Intercellular Communication, College of 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