{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:54:06Z","timestamp":1792526046316,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["IC170100022"],"award-info":[{"award-number":["IC170100022"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Combating the accumulated senescent cells and the healing of osteoporotic bone fractures in the older remains a significant challenge. Nicotinamide mononucleotide (NMN), a precursor of NAD+, is an excellent candidate for mitigating aging-related disorders. However, it is unknown if NMN can alleviate senescent cell induction and enhance osteoporotic bone fracture healing. Here we show that NMN treatment partially reverses the effects of tumor necrosis factor-alpha (TNF-\u03b1) on human primary osteoblasts (HOBs): senescent cell induction, diminished osteogenic differentiation ability, and intracellular NAD+ and NADH levels. Mechanistically, NMN restores the mitochondrial dysfunction in HOBs induced by TNF-\u03b1 evidenced by increased mitochondrial membrane potential and reduced reactive oxidative species and mitochondrial mass. NMN also increases mitophagy activity by down-regulating P62 expression and up-regulating light chain 3B-II protein expression. In addition, the cell senescence protective effects of NMN on HOBs are mitigated by a mitophagy inhibitor (Bafilomycin A1). In vivo, NMN supplementation attenuates senescent cell induction in growth plates, partially prevents osteoporosis in an ovariectomized mouse model, and accelerates bone healing in osteoporotic mice. We conclude that NMN can be a novel and promising therapeutic candidate to enhance bone fracture healing capacity in the older.<\/jats:p>","DOI":"10.1093\/gerona\/glac175","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T13:08:01Z","timestamp":1661778481000},"page":"186-194","source":"Crossref","is-referenced-by-count":28,"title":["Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-4441","authenticated-orcid":false,"given":"ZuFu","family":"Lu","sequence":"first","affiliation":[{"name":"Biomaterials and Tissue Engineering Research Unit, School of Biomedical Engineering, the University of Sydney , Sydney, New South Wales , Australia"},{"name":"ARC Training Centre for Innovative BioEngineering, the University of Sydney , Sydney, New South Wales , 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Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R","family":"Dunstan","sequence":"additional","affiliation":[{"name":"Biomaterials and Tissue Engineering Research Unit, School of Biomedical Engineering, the University of Sydney , Sydney, New South Wales , Australia"},{"name":"ARC Training Centre for Innovative BioEngineering, the University of Sydney , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinQuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine"},{"name":"National Clinical Research Center for Oral diseases, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology , Shanghai , 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