{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:58:28Z","timestamp":1787756308618,"version":"build-2784847793"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French Ministry of Health","award":["PHRC 2008, 2009"],"award-info":[{"award-number":["PHRC 2008, 2009"]}]},{"name":"University Hospital Center of Toulouse\/G\u00e9rontop\u00f4le, Pierre Fabre Research Institute"},{"name":"ExonHit Therapeutics"},{"DOI":"10.13039\/100014392","name":"Avid Radiopharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006556","name":"University Hospital Center of Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association Monegasque pour la Recherche sur la maladie d\u2019Alzheimer"},{"name":"Unit INSERM-University of Toulouse III"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG061900"],"award-info":[{"award-number":["R56AG061900"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG061900"],"award-info":[{"award-number":["RF1AG061900"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010390","name":"Saint Louis University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010390","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Occitanie"},{"name":"Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","award":["1901175"],"award-info":[{"award-number":["1901175"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MP0022856"],"award-info":[{"award-number":["MP0022856"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimer Prevention in Occitania and Catalonia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) \u03b54 status. This cross-sectional analysis included 475 participants \u226570 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-\u03b2\u200a42\/40\u2014A\u03b2\u200a42\/40, neurofilament light chain\u2014NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine\u2014Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1\u2014TNFR-1, monocyte chemoattractant protein 1\u2014MCP-1, interleukin 6\u2014IL-6), and cellular stress (plasma growth differentiation factor 15\u2014GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE \u03b54 status. After adjusting for confounders, A\u03b2\u200a42\/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE \u03b54 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.<\/jats:p><jats:p>Clinical Trials Registration Number: NCT00672685<\/jats:p>","DOI":"10.1093\/gerona\/glac244","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T18:20:05Z","timestamp":1670869205000},"page":"569-578","source":"Crossref","is-referenced-by-count":14,"title":["TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-8309","authenticated-orcid":false,"given":"Kelly Virecoulon","family":"Giudici","sequence":"first","affiliation":[{"name":"Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Morley","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, School of Medicine, Saint Louis University , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-9472","authenticated-orcid":false,"given":"Andrew D","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, School of Medicine, Saint Louis University , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, School of Medicine, Saint Louis University , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Parini","sequence":"additional","affiliation":[{"name":"Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM UMR 1048, University of Toulouse III Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"},{"name":"Division of Biostatistics, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall John","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"MAPT\/DSA 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