{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:44:21Z","timestamp":1788410661372,"version":"build-2803163510"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain may increase the risk for sarcopenia, but existing literature is only from high-income countries, while the mediators of this association are largely unknown. Thus, we aimed to investigate the association between pain and sarcopenia using nationally representative samples of older adults from 6 low- and middle-income countries (LMICs), and to identify potential mediators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Sarcopenia was defined as having low skeletal muscle mass and weak handgrip strength, while the presence and severity of pain in the last 30\u00a0days were self-reported. Multivariable logistic regression and mediation analyses were performed. The control variables included age, sex, education, wealth, and chronic conditions, while affect, sleep\/energy, disability, social participation, sedentary behavior, and mobility were considered potential mediators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data on 14,585 adults aged \u226565\u00a0years were analyzed (mean [SD] age 72.6 [11.5] years; 55.0% females). Compared to no pain, mild, moderate, severe, and extreme pain were associated with 1.42 (95% confidence interval [CI]\u00a0=\u00a01.05\u20131.94), 1.43 (95%CI\u00a0=\u00a01.02\u20132.00), 1.92 (95%CI\u00a0=\u00a01.09\u20133.37), and 2.88 (95%CI\u00a0=\u00a01.10\u20137.54) times higher odds for sarcopenia, respectively. Disability (mediated percentage 18.0%), sedentary behavior (12.9%), and low mobility (56.1%) were significant mediators in the association between increasing levels of pain and sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher levels of pain were associated with higher odds for sarcopenia among adults aged \u226565\u00a0years in 6 LMICs. Disability, sedentary behavior, and mobility problems were identified as potential mediators. Targeting these factors in people with pain may decrease the future risk of sarcopenia onset, pending future longitudinal research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glad002","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T16:19:07Z","timestamp":1672849147000},"page":"1020-1027","source":"Crossref","is-referenced-by-count":13,"title":["Association Between Pain and Sarcopenia Among Adults Aged \u226565 Years from Low- and Middle-Income Countries"],"prefix":"10.1093","volume":"78","author":[{"given":"Lee","family":"Smith","sequence":"first","affiliation":[{"name":"Centre for Health Performance and Wellbeing, Anglia Ruskin University , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-5273","authenticated-orcid":false,"given":"Guillermo\u00a0F","family":"L\u00f3pez S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia , Murcia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Veronese","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geriatrics Section, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-1718","authenticated-orcid":false,"given":"Pinar","family":"Soysal","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7227","authenticated-orcid":false,"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[{"name":"University Clinic of Marburg , Marburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Jacob","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, CIBERSAM, ISCIII, Dr. Antoni Pujadas , Sant Boi de Llobregat, Barcelona , Spain"},{"name":"Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines , Montigny-le-Bretonneux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-027X","authenticated-orcid":false,"given":"Masoud","family":"Rahmati","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University , Khoramabad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-8478","authenticated-orcid":false,"given":"Agnieszka","family":"Kujawska","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology and Functional Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toru\u0144 , Bydgoszcz , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0A","family":"Tully","sequence":"additional","affiliation":[{"name":"School of Medicine. Ulster University , Londonderry, Northern Ireland , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Butler","sequence":"additional","affiliation":[{"name":"Centre for Health Performance and Wellbeing, Anglia Ruskin University , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-1820","authenticated-orcid":false,"given":"Jae","family":"Il Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yonsei University College of Medicine , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, CIBERSAM, ISCIII, Dr. Antoni Pujadas , Sant Boi de Llobregat, Barcelona , Spain"},{"name":"ICREA , Barcelona , 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