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The aim of this study was to adapt the concept of frailty to the domestic dog, as a model for frailty research, by characterizing a 5-criterion frailty phenotype using objective measurement, and to investigate its independent association with death. A prospective cohort including 80 Labrador and Golden Retriever dogs aged 9 years or older was conducted between March 2015 and July 2020. An adapted frailty phenotype was defined according to the presence of 5 criteria (weakness, slowness, poor endurance, low physical activity, and shrinking) evaluated at baseline from physical performance tests and items from questionnaire and physical examination. Survival analysis was used to investigate the association between frailty status and time to all-cause death over 5 years of follow-up. Frailty status was significantly associated with all-cause death, with median survival times of 10.5 months, 35.4 months, and 42.5 months, respectively for dogs with 3 or more criteria (frail dogs), dogs with 1 or 2 criteria (prefrail dogs), and nonfrail dogs. Independently of age, sex, breed, sterilization, and sex-sterilization interaction, frail dogs died significantly faster than nonfrail dogs at baseline (adjusted hazard ratio = 5.86; 95% confidence interval = 2.45\u201314.0; p &amp;lt; .01). This significant association persisted after controlling for other potential confounders. Frailty, assessed by a 5-criterion phenotype, was predictive of all-cause death, in geriatric Labrador and Golden Retriever dogs. The concept of frailty seems adaptable to the dog.<\/jats:p>","DOI":"10.1093\/gerona\/glad006","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T13:32:11Z","timestamp":1672925531000},"page":"1355-1363","source":"Crossref","is-referenced-by-count":21,"title":["Canine Model of Human Frailty: Adaptation of a Frailty Phenotype in Older Dogs"],"prefix":"10.1093","volume":"78","author":[{"given":"Romane","family":"Lemar\u00e9chal","sequence":"first","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort , Maisons-Alfort , France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hoummady","sequence":"additional","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort , Maisons-Alfort , France"},{"name":"Laboratoire MECADEV, UMR 7179, CNRS-MNHN , Brunoy , 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