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Enrollees were age \u226570 years, able to walk \u22650.6 m\/s (4 m); able to complete 400 m walk, free of life-threatening disease, and had no contraindications to magnetic resonance or tissue collection. Participants are followed with 6-month phone contacts and annual in-person exams. At baseline, SOMMA collected biospecimens (muscle and adipose tissue, blood, urine, fecal samples); a variety of questionnaires; physical and cognitive assessments; whole-body imaging (magnetic resonance and computed tomography); accelerometry; and cardiopulmonary exercise testing. Primary outcomes include change in walking speed, change in fitness, and objective mobility disability (able to walk 400 m in 15 minutes and change in 400 m speed). Incident events, including hospitalizations, cancer diagnoses, fractures, and mortality are collected and centrally adjudicated by study physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SOMMA exceeded its goals by enrolling 879 participants, despite being slowed by the COVID-19 pandemic: 59.2% women; mean age 76.3 \u00b1 5.0 years (range 70\u201394); mean walking speed 1.04 \u00b1 0.20 m\/s; 15.8% identify as other than Non-Hispanic White. Over 97% had data for key measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SOMMA will provide the foundation for discoveries in the biology of human aging and mobility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glad052","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T20:02:36Z","timestamp":1675886556000},"page":"2083-2093","source":"Crossref","is-referenced-by-count":102,"title":["The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility"],"prefix":"10.1093","volume":"78","author":[{"given":"Steven R","family":"Cummings","sequence":"first","affiliation":[{"name":"San Francisco Coordinating Center, California Pacific Medical Center Research Institute , San Francisco, California , USA"},{"name":"Department of Epidemiology 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