{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:13:40Z","timestamp":1793038420459,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Associations of the rate of height loss (RHL) with cognitive decline and dementia in middle-aged and older adults have not been examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study included 3 610 participants aged 50 years and older from the English Longitudinal Study of Ageing. Standing height was measured with standardized protocols. RHL was estimated as an annualized percentage of height loss (% per year) during Waves 0\u20134, and was categorized into slow (&amp;lt;0.1%), medium (\u22650.1% and &amp;lt;0.2%), and fast (\u22650.2%). Associations between RHL and cognitive decline and incident dementia were analyzed using mixed-effects models and Cox regression models, respectively (Waves 5\u20139).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 283 individuals identified with incident dementia over a mean follow-up of 7.21 years. Compared with participants in the slow group, those in the medium (coefficient [\u03b2] = \u22120.016, 95% confidence interval [CI] = \u22120.023 to \u22120.009) and fast groups (\u03b2 = \u22120.030, 95% CI = \u22120.039 to \u22120.021) had faster declines in cognition. Faster height loss was also associated with increased risks of incident dementia (medium vs slow, hazard ratio [HR] = 1.37, 95% CI = 1.03\u20131.81; fast vs slow, HR = 1.75, 95% CI = 1.29\u20132.37). Besides, associations of RHL with cognitive decline were stronger in females than in males.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings indicated that rapid RHL was associated with faster declines in cognition and elevated risks of dementia. RHL may serve as an early marker of progressed neurodegeneration in middle-aged and older adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glad054","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:04:05Z","timestamp":1675904645000},"page":"1445-1452","source":"Crossref","is-referenced-by-count":7,"title":["Associations of Height Loss With Cognitive Decline and Incident Dementia in Adults Aged 50 Years and Older"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2177-6970","authenticated-orcid":false,"given":"Jing","family":"Guo","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women\u2019s Hospital, Zhejiang University School of Medicine , Zhejiang, Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, College of Public Health, University of Georgia , Athens, Georgia , USA"},{"name":"The Taub Institute for Research in Alzheimer\u2019s Disease and the Aging Brain, Columbia University , New York, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"2023080214433112100_CIT0001","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2022","journal-title":"Lancet Public 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