{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:10:03Z","timestamp":1793304603962,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Network for Investigation of Delirium: Unifying Scientists"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24AG054259 and R33AG071744"],"award-info":[{"award-number":["R24AG054259 and R33AG071744"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundacao de Amparo a Pesquisa do Estado de S\u00e3o Paulo","award":["2016\/14566-4"],"award-info":[{"award-number":["2016\/14566-4"]}]},{"name":"Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our aim was to investigate the association between gut microbiota and delirium occurrence in acutely ill older adults. We included 133 participants 65+ years consecutively admitted to the emergency department of a tertiary university hospital, between September 2019 and March 2020. We excluded candidates with \u226524-hour antibiotic utilization on admission, recent prebiotic or probiotic utilization, artificial nutrition, acute gastrointestinal disorders, severe traumatic brain injury, recent hospitalization, institutionalization, expected discharge \u226448 hours, or admission for end-of-life care. A trained research team followed a standardized interview protocol to collect sociodemographic, clinical, and laboratory data on admission and throughout the hospital stay. Our exposure measures were gut microbiota alpha and beta diversities, taxa relative abundance, and core microbiome. Our primary outcome was delirium, assessed twice daily using the Confusion Assessment Method. Delirium was detected in 38 participants (29%). We analyzed 257 swab samples. After adjusting for potential confounders, we observed that a greater alpha diversity (higher abundance and richness of microorganisms) was associated with a lower risk of delirium, as measured by the Shannon (odds ratio [OR] = 0.77; 95% confidence interval [CI] = 0.60\u20130.99; p = .042) and Pielou indexes (OR = 0.69; 95% CI = 0.51\u20130.87; p = .005). Bacterial taxa associated with pro-inflammatory pathways (Enterobacteriaceae) and modulation of relevant neurotransmitters (Serratia: dopamine; Bacteroides, Parabacteroides: GABA) were more common in participants with delirium. Gut microbiota diversity and composition were significantly different in acutely ill hospitalized older adults who experienced delirium. Our work is an original proof-of-concept investigation that lays a foundation for future biomarker studies and potential therapeutic targets for delirium prevention and treatment.<\/jats:p>","DOI":"10.1093\/gerona\/glad074","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T22:39:10Z","timestamp":1677796750000},"page":"1320-1327","source":"Crossref","is-referenced-by-count":29,"title":["Association Between Gut Microbiota and Delirium in Acutely Ill Older Adults"],"prefix":"10.1093","volume":"78","author":[{"given":"Flavia Barreto","family":"Garcez","sequence":"first","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM 66), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"},{"name":"Departamento de Medicina, Hospital Universitario, Universidade Federal de Sergipe , S\u00e3o Crist\u00f3v\u00e3o , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-6060","authenticated-orcid":false,"given":"J\u00falio C\u00e9sar","family":"Garcia de Alencar","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Emergencias Clinicas (LIM 51), Departamento de Cl\u00ednica M\u00e9dica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Steffany Mu\u00f1oz","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Departamento de Nutricao, Faculdade de Saude Publica, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Iida","family":"Avelino-Silva","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"},{"name":"Faculdade Israelita de Ciencias da Saude Albert Einstein, Hospital Israelita Albert Einstein , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Cerdeira","family":"Sabino","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"},{"name":"Laborat\u00f3rio de Parasitologia Medica (LIM 46), Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Cristina Ruedas","family":"Martins","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Medica (LIM 46), Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Augusto Moys\u00e9s","family":"Franco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Medica (LIM 46), Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Maria","family":"Lima Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Nutricao, Faculdade de Saude Publica, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heraldo","family":"Possolo de Souza","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Emergencias Clinicas (LIM 51), Departamento de Cl\u00ednica M\u00e9dica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Junqueira","family":"Avelino-Silva","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM 66), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"},{"name":"Faculdade Israelita de Ciencias da Saude Albert Einstein, Hospital Israelita Albert Einstein , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"issue":"1","key":"2023080214431743400_CIT0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-015-0094-5","article-title":"The vocabulary of microbiome research: a 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