{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:27:09Z","timestamp":1769020029166,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672377"],"award-info":[{"award-number":["31672377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Annual fishes of the genus Nothobranchius have been widely used in cognitive, behavioral, and genetic studies, and have become an excellent animal model for studying aging. However, the development and degeneration of immune organs in annual fishes and the antagonistic effects of resveratrol remain unclear. In the present study, the development of thymus and kidney was investigated systematically using Nothobranchius guentheri from larvae, juveniles, and young and old fish with hematoxylin and eosin staining. We found that thymus primordium was observed first in the larvae at 2\u00a0days after hatching (dah). After the lymphoid cells became evident at 5 dah, the thymus acquired an irregular shape at 7 dah. Then it formed a wedge shape at 15 dah. Thymus looked as homogeneous distribution of lymphocytes at 1\u00a0month old, and it differentiated into cortex and medulla approximately in 2-month-old fish. Combined with TUNEL and senescence-associated \u03b2-galactosidase (SA-\u03b2-gal) staining, it showed the degeneration of the thymus appeared in 4-month-old fish. Kidney primordium appeared on 1 dah, and the glomerulus was visible at 7 dah. The nephrogenic activity was most apparent in 1-month-old fish. A\u00a0large hematopoietic tissue was arranged in the renal interstitium in 2- and 3-month-old fish. In 6-month-old fish, the kidney structure became less dense. By 12\u00a0months, the kidney exhibited the most pronounced histological characteristics of aging. Feeding resveratrol ameliorated renal fibrosis and SA-\u03b2-gal staining with age, increased SIRT1 and SIRT3 expression, and decreased the levels of NF-\u03baB and inflammatory factors in thymus and kidney of the fish. We provided basic data for the development and degeneration of immune organs and resveratrol\u2019s anti-aging effects in short-lived fish.<\/jats:p>","DOI":"10.1093\/gerona\/glad089","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T15:17:12Z","timestamp":1679325432000},"page":"1550-1557","source":"Crossref","is-referenced-by-count":6,"title":["Development of the Thymus and Kidney and Effects of Resveratrol on Their Aging in a Short-Lived\u00a0Fish"],"prefix":"10.1093","volume":"78","author":[{"given":"Yanhan","family":"Hou","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxue","family":"Qiao","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, Shandong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, Shandong , 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