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The detailed analysis of pineal structure was done on autopsy material of 77 persons in age 27\u201396 using x-ray phase-contrast tomography, histology, and immunohistochemistry. Our study suggests that the pineal gland alteration in older adults may be more profound than has been reported to date. We identified and described a new form of pineal gland involution that eventually led to the total degradation of the pineal gland. To our knowledge, this study is the first to report on the complete replacement of pineal gland parenchyma with connective tissue in older adults.<\/jats:p>","DOI":"10.1093\/gerona\/glad091","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T08:53:31Z","timestamp":1679734411000},"page":"1558-1560","source":"Crossref","is-referenced-by-count":4,"title":["Human Pineal Gland Involutionary Process: New Findings"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-5393","authenticated-orcid":false,"given":"Olga","family":"Junemann","sequence":"first","affiliation":[{"name":"Institute of Nanotechnology-CNR , Rome , Italy"},{"name":"Avtsyn Research Institute of Human Morphology of FSBSI, Petrovsky National Research Centre of Surgery , Moscow , Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Bukreeva","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology-CNR , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry A","family":"Otlyga","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology of FSBSI, Petrovsky National Research Centre of Surgery , Moscow , Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Cedola","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology-CNR , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Fratini","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology-CNR , Rome , Italy"},{"name":"Santa Lucia Foundation , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei V","family":"Saveliev","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology of FSBSI, Petrovsky National Research Centre of Surgery , Moscow , Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"2023082713550702200_CIT0001","volume-title":"Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. 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