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Therefore, we examined associations of vascular health measures with grip strength and gait speed in adults from the Framingham Heart Study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The cross-sectional study (1998\u20132001) included participants with 1 measure of grip strength (kg, dynamometer) or gait speed (4-m walk, m\/s) and at least 1 measure of aortic stiffness (carotid\u2013femoral pulse wave velocity, brachial pulse pressure, and brachial flow pulsatility index) or brachial artery structure and function (resting flow velocity, resting brachial artery diameter, flow-mediated dilation %, hyperemic brachial blood flow velocity, and mean arterial pressure [MAP]) assessed by tonometry and brachial artery ultrasound. The longitudinal study included participants with \u22651 follow-up measurement of gait speed or grip strength. Multivariable linear regression estimated the association of 1 standard deviation (SD) higher level of each vascular measure with annualized percent change in grip strength and gait speed, adjusting for covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In cross-sectional analyses (n = 2 498, age 61 \u00b1 10 years; 56% women), higher resting brachial artery diameter (\u03b2 \u00b1 standard error [SE] per 1 SD: 0.59 \u00b1 0.24, p = .01) and MAP (\u03b2 \u00b1 SE: 0.39 \u00b1 0.17, p = .02) were associated with higher grip strength. Higher brachial pulse pressure (\u03b2 \u00b1 SE: \u22120.02 \u00b1 0.01, p = .07) was marginally associated with slower gait speed. In longitudinal analyses (n = 2 157), higher brachial pulse pressure (\u03b2 \u00b1 SE: \u22120.19 \u00b1 0.07, p = .005), was associated with slowing of gait speed but not with grip strength.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Higher brachial artery pulse pressure (measure of aortic stiffness) was associated with loss of physical function over ~11 years, although we found no evidence that microvascular function contributed to the relation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glad097","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T06:05:09Z","timestamp":1684130709000},"page":"1189-1197","source":"Crossref","is-referenced-by-count":4,"title":["Association of Vascular Health Measures and Physical Function: A Prospective Analysis in the Framingham Heart 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