{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:27:55Z","timestamp":1785392875821,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We investigated the associations between habitual use of glucosamine and incident dementia and Parkinson\u2019s disease in a population-based cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using the UK Biobank data, we included around 0.29 million middle- to old-aged participants free of dementia or Parkinson\u2019s disease at baseline. Glucosamine supplementation was measured by questionnaire at baseline. Some participants additionally answered 1\u20135 rounds of 24-hour dietary recalls afterwards, particularly 112 243 participants (for dementia) and 112 084 (for Parkinson\u2019s disease). Incident cases of dementia and Parkinson\u2019s disease were identified through linkage to health administrative data sets. We examined the associations of glucosamine supplementation with incident dementia and Parkinson\u2019s disease using Cox proportional-hazards regression models with adjustment for various covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period (median follow-up: 9.1\u201310.9 years), 4 404 and 1 637 participants developed dementia and Parkinson\u2019s disease, respectively. Glucosamine intake was not associated with incident dementia or Parkinson\u2019s disease. In fully adjusted models, the hazard ratios associated with glucosamine intake were 1.06 [95% confidence interval (CI): 0.99, 1.14] for dementia and 0.97(95% CI: 0.86, 1.09) for Parkinson\u2019s disease. In the subsample, similar results were found as the frequency of reported glucosamine use over multiple dietary surveys was associated with neither of the 2 conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Habitual supplementation of glucosamine was not associated with incident dementia or Parkinson\u2019s disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glad123","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:12:40Z","timestamp":1683767560000},"source":"Crossref","is-referenced-by-count":6,"title":["No Associations Between Glucosamine Supplementation and Dementia or Parkinson\u2019s Disease: Findings From a Large Prospective Cohort Study"],"prefix":"10.1093","volume":"79","author":[{"given":"Baozhuo","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Service Management, Shenzhen University , Shenzhen , 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