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This ground-breaking study tested specific hypotheses about the importance of weight, body composition, and weight-related health conditions for incident functional limitation in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative review with analysis of ancillary studies, career awards, publications, and citations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Key findings of the study demonstrated the importance of body composition as a whole, both fat and lean mass, in the disablement pathway. The quality of the muscle in terms of its strength and its composition was found to be a critical feature in defining sarcopenia. Dietary patterns and especially protein intake, social factors, and cognition were found to be critical elements for functional limitation and disability. The study is highly cited and its assessments have been widely adopted in both observational studies and clinical trials. Its impact continues as a platform for collaboration and career development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Health ABC provides a knowledge base for the prevention of disability and promotion of mobility in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glad167","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T20:59:56Z","timestamp":1689022796000},"page":"2024-2034","source":"Crossref","is-referenced-by-count":45,"title":["The Health, Aging, and Body Composition (Health ABC) Study\u2014Ground-Breaking Science for 25 Years and Counting"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0106-1150","authenticated-orcid":false,"given":"Anne B","family":"Newman","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-298X","authenticated-orcid":false,"given":"Marjolein","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-6781","authenticated-orcid":false,"given":"Stephen B","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wake Forest University School of Medicine , Winston-Salem, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-3494","authenticated-orcid":false,"given":"Eleanor","family":"Simonsick","sequence":"additional","affiliation":[{"name":"National Institute on Aging, Translational Gerontology Branch Biomedical Research Center , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy M","family":"Cawthon","sequence":"additional","affiliation":[{"name":"Research Institute, California Pacific Medical Center, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B","family":"Harris","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, Intramural Research Program NIA, NIH , Bethesda, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"2023102819044229700_CIT0001","doi-asserted-by":"crossref","first-page":"M644","DOI":"10.1093\/gerona\/56.10.M644","article-title":"Measuring higher level physical function in well-functioning older adults: expanding familiar approaches in the Health ABC study","volume":"56","author":"Simonsick","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"2023102819044229700_CIT0002","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/acel.12568","article-title":"Muscle strength mediates the relationship between mitochondrial energetics and walking performance","volume":"16","author":"Zane","year":"2017","journal-title":"Aging Cell."},{"key":"2023102819044229700_CIT0003","article-title":"The Study of Muscle, Mobility and Aging (SOMMA). 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