{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:17:46Z","timestamp":1788614266167,"version":"build-2803163510"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["107-2628-H-003-003-MY3"],"award-info":[{"award-number":["107-2628-H-003-003-MY3"]}]},{"name":"National Science and Technology Council, Taiwan","award":["110-2410-H-003-142-MY3"],"award-info":[{"award-number":["110-2410-H-003-142-MY3"]}]},{"name":"National Science and Technology Council, Taiwan","award":["111-2918-I-003-001"],"award-info":[{"award-number":["111-2918-I-003-001"]}]},{"name":"\u201cSocial Emotional Education and Development Center\u201d of National Taiwan Normal University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute exercise is a behavior that benefits cognitive function; however, its effect on populations with different risks for Alzheimer\u2019s disease (AD) and the role of exercise variance and Apolipoprotein E (APOE) genotype on this effect remains unknown. This study explores the acute exercise effect on behavioral and neurocognitive function, and its potential moderation by exercise intensity and duration and APOE genetic risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifty-one cognitively normal adults (~36% APOE \u03b54 carriers) performed the Stroop task under a rest condition and 3 exercise conditions while electroencephalographic activity was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Acute exercise improved cognitive performance assessed through both behavioral and neuroelectrical indices. These benefits were observed regardless of adjustments of intensity and duration at a predetermined exercise volume as well as being evident irrespective of APOE \u025b4 carrier status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Acute exercise could be proposed as a lifestyle intervention to benefit neurocognitive function in populations with and without genetic risk of AD. Future exploration should further the precise exercise prescription and also the mechanisms underlying the beneficial effects of acute exercise for neurocognitive function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration Number<\/jats:title>\n                  <jats:p>NCT05591313<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glad179","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T11:16:10Z","timestamp":1690888570000},"source":"Crossref","is-referenced-by-count":7,"title":["Acute Exercise Effect on Neurocognitive Function Among Cognitively Normal Late-Middle-Aged Adults With\/Without Genetic Risk of AD: The Moderating Role of Exercise Volume and <i>APOE<\/i> Genotype"],"prefix":"10.1093","volume":"79","author":[{"given":"Yu-Kai","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sport Sciences, National Taiwan Normal University , Taipei , Taiwan"},{"name":"Institute for Research Excellence in Learning Science, National Taiwan Normal University , Taipei , Taiwan"},{"name":"Social Emotional Education and Development Center, National Taiwan Normal University , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Etnier","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of North Carolina at Greensboro , Greensboro, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruei-Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Sciences, National Taiwan Normal University , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Fei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Beijing Language and Culture University , Beijing , 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