{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:59:04Z","timestamp":1791986344852,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG 059416"],"award-info":[{"award-number":["AG 059416"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","award":["P30 AG024827"],"award-info":[{"award-number":["P30 AG024827"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"publisher","award":["P30 AG021332"],"award-info":[{"award-number":["P30 AG021332"]}],"id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 0TR001420"],"award-info":[{"award-number":["UL1 0TR001420"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pittsburgh Epidemiology of Aging Training Program","award":["NIA T32 AG000181"],"award-info":[{"award-number":["NIA T32 AG000181"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Pittsburgh Performance Fatigability Index (PPFI) quantifies the percent decline in cadence using accelerometry during standardized walking tasks. Although PPFI has shown strong correlations with physical performance, the developmental sample was relatively homogenous and small, necessitating further validation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants from the Study of Muscle, Mobility and Aging (N\u2005=\u2005805, age\u2005=\u200576.4\u2005\u00b1\u20055.0 years, 58% women, 85% White) wore an ActiGraph GT9X on the nondominant wrist during usual-paced 400 m walk. Tri-axial accelerations were analyzed to compute PPFI (higher score\u2005=\u2005greater fatigability). To evaluate construct and discriminant validity, Spearman correlations (rs) between PPFI and gait speed, Short Physical Performance Battery (SPPB), chair stand speed, leg peak power, VO2peak, perceived fatigability, and mood were examined. Sex-specific PPFI cut-points that optimally discriminated gait speed using classification and regression tree were then generated. Their discriminate power in relation to aforementioned physical performance were further evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Median PPFI score was 1.4% (25th\u201375th percentile range: 0%\u201321.7%), higher among women than men (p\u2005&amp;lt;\u2005.001). PPFI score was moderate-to-strongly correlated with gait speed (rs\u2005=\u2005\u22120.75), SPPB score (rs\u2005=\u2005\u22120.38), chair stand speed (rs\u2005=\u2005\u22120.36), leg peak power (rs\u2005=\u2005\u22120.34) and VO2peak (rs\u2005=\u2005\u22120.40), and less strongly with perceived fatigability (rs\u2005=\u20050.28\u20130.29), all p\u2005&amp;lt;\u2005.001. PPFI score was not correlated with mood (|rs| &amp;lt; 0.08). Sex-specific PPFI cut-points (no performance fatigability: PPFI\u2005=\u20050%; mild performance fatigability: 0% &amp;lt; PPFI &amp;lt; 3.5% [women], 0% &amp;lt; PPFI &amp;lt; 5.4% [men]; moderate-to-severe performance fatigability: PPFI\u2005\u2265\u20053.5% [women], PPFI\u2005\u2265\u20055.4% [men]) discriminated physical performance (all p\u2005&amp;lt;\u2005.001), adjusted for demographics and smoking status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our work underscores the utility of PPFI as a valid measure to quantify performance fatigability in future longitudinal epidemiologic studies and clinical\/pharmaceutical trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glad197","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T15:14:45Z","timestamp":1691766885000},"page":"2387-2395","source":"Crossref","is-referenced-by-count":8,"title":["Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-3320","authenticated-orcid":false,"given":"Yujia (Susanna)","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Harezlak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University , Bloomington, Indiana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy M","family":"Cawthon","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center, California Pacific Medical Center Research Institute , San Francisco, California , USA"},{"name":"Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Cummings","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center, California Pacific Medical Center Research Institute , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5697-2189","authenticated-orcid":false,"given":"Daniel E","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Medicine (Divisions of Geriatrics and Cardiology), School of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-5147","authenticated-orcid":false,"given":"Bret H","family":"Goodpaster","sequence":"additional","affiliation":[{"name":"AdventHealth, Translational Research Institute , Orlando, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marquis","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-6357","authenticated-orcid":false,"given":"Kyle D","family":"Moored","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J","family":"Nicklas","sequence":"additional","affiliation":[{"name":"Gerontology and Geriatric Medicine, Wake Forest School of Medicine , Winston-Salem, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico G S","family":"Toledo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-5068","authenticated-orcid":false,"given":"Pamela E","family":"Toto","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-2909","authenticated-orcid":false,"given":"Adam J","family":"Santanasto","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa S","family":"Strotmeyer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-0162","authenticated-orcid":false,"given":"Nancy W","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"2023120205435861700_CIT0001","first-page":"e013049","article-title":"Association between cardiovascular risk and perceived fatigability in mid-to-late life","volume-title":"J Am Heart Assoc","author":"Qiao","year":"2019"},{"key":"2023120205435861700_CIT0002","first-page":"1455","article-title":"Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions","volume-title":"J Health Psychol.","author":"Carlozzi","year":"2021"},{"key":"2023120205435861700_CIT0003","first-page":"487","article-title":"Walking energetics, fatigability, and fatigue in older adults: the study of energy and aging pilot","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Richardson","year":"2015"},{"key":"2023120205435861700_CIT0004","first-page":"e74","article-title":"Longitudinal association between energy regulation and fatigability in mid-to-late life","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Schrack","year":"2020"},{"key":"2023120205435861700_CIT0005","first-page":"630","article-title":"Perceived fatigability and objective physical activity in mid- to late-life","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Wanigatunga","year":"2018"},{"key":"2023120205435861700_CIT0006","first-page":"347","article-title":"Assessing fatigability in mobility-intact older adults","volume-title":"J Am Geriatr Soc.","author":"Simonsick","year":"2014"},{"key":"2023120205435861700_CIT0007","first-page":"1287","article-title":"Fatigued, but not frail: perceived fatigability as a marker of impending decline in mobility-intact older adults","volume-title":"J Am Geriatr Soc.","author":"Simonsick","year":"2016"},{"key":"2023120205435861700_CIT0008","first-page":"2329","article-title":"Life-space mobility in older men: the role of perceived physical and mental fatigability","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Moored","year":"2022"},{"key":"2023120205435861700_CIT0009","first-page":"967","article-title":"Bedside-to-bench conference: research agenda for idiopathic fatigue and aging","volume-title":"J Am Geriatr Soc.","author":"Alexander","year":"2010"},{"key":"2023120205435861700_CIT0010","first-page":"837","article-title":"Perceived physical fatigability predicts all-cause mortality in older adults","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Glynn","year":"2021"},{"key":"2023120205435861700_CIT0011","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/ptj\/86.5.726","article-title":"Toward a common language for function, disability, and health","volume":"86","author":"Jette","year":"2006","journal-title":"Phys Ther."},{"key":"2023120205435861700_CIT0012","first-page":"406","article-title":"Fatigue and fatigability in older adults","volume-title":"PM R","author":"Eldadah","year":"2010"},{"key":"2023120205435861700_CIT0013","first-page":"e63","article-title":"Fatigability: a prognostic indicator of phenotypic aging","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Schrack","year":"2020"},{"key":"2023120205435861700_CIT0014","first-page":"960","article-title":"Distinguishing between fatigue and fatigability in multiple sclerosis","volume-title":"Neurorehabil Neural Repair.","author":"Enoka","year":"2021"},{"key":"2023120205435861700_CIT0015","first-page":"e161","article-title":"Response to \u201ccomment on: fatigability: a prognostic indicator of phenotypic aging\u201d","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Glynn","year":"2021"},{"key":"2023120205435861700_CIT0016","first-page":"1782","article-title":"Development of a novel accelerometry-based performance fatigability measure for older adults","volume-title":"Med Sci Sports Exerc.","author":"Qiao","year":"2022"},{"key":"2023120205435861700_CIT0017","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glad052","article-title":"The Study of Muscle, Mobility and Aging (SOMMA):a unique cohort study about the cellular biology of aging and age-related loss of mobility","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Cummings","year":"2023"},{"key":"2023120205435861700_CIT0018","first-page":"841","article-title":"Mobility limitation in self-described well-functioning older adults: importance of endurance walk testing","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Simonsick","year":"2008"},{"key":"2023120205435861700_CIT0019","first-page":"331","article-title":"Adaptive empirical pattern transformation (ADEPT) with application to walking stride segmentation","volume-title":"Biostatistics","author":"Karas","year":"2019"},{"key":"2023120205435861700_CIT0020","first-page":"M85","article-title":"A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume-title":"J Gerontol","author":"Guralnik","year":"1994"},{"key":"2023120205435861700_CIT0021","first-page":"1379","article-title":"Skeletal muscle mitochondrial function and fatigability in older adults","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Santanasto","year":"2015"},{"key":"2023120205435861700_CIT0022","first-page":"1392","article-title":"Dual roles of cardiorespiratory fitness and fatigability in the life-space mobility of older adults: The Study of Muscle Mobility and Aging (SOMMA)","volume-title":"J Geronotol A Biol Sci Med Sci","author":"Moored","year":"2023"},{"key":"2023120205435861700_CIT0023","first-page":"130","article-title":"The Pittsburgh Fatigability Scale for older adults: development and validation","volume-title":"J Am Geriatr Soc.","author":"Glynn","year":"2015"},{"key":"2023120205435861700_CIT0024","first-page":"1343","article-title":"Validation of perceived mental fatigability using the Pittsburgh Fatigability Scale","volume-title":"J Am Geriatr Soc.","author":"Renner","year":"2021"},{"key":"2023120205435861700_CIT0025","first-page":"832","article-title":"Are BMI and inflammatory markers independently associated with physical fatigability in old age","volume-title":"Int J Obes.","author":"Cooper","year":"2019"},{"key":"2023120205435861700_CIT0026","first-page":"385","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume-title":"Appl Psychol Meas","author":"Radloff","year":"1977"},{"key":"2023120205435861700_CIT0027","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-007-5061-6","volume-title":"The epidemiology of aging","author":"Newman","year":"2012"},{"key":"2023120205435861700_CIT0028","first-page":"1527","article-title":"Evaluation of two fatigability severity measures in elderly adults","volume-title":"J Am Geriatr Soc.","author":"Schnelle","year":"2012"},{"key":"2023120205435861700_CIT0029","first-page":"115","article-title":"Assessing fatigability in the lab and in daily life in older adults with osteoarthritis using perceived, performance, and ecological measures","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Murphy","year":"2017"},{"key":"2023120205435861700_CIT0030","first-page":"179","article-title":"Fatigability as a function of physical activity energy expenditure in older adults","volume-title":"Age (Omaha)","author":"Buchowski","year":"2013"},{"key":"2023120205435861700_CIT0031","first-page":"78","article-title":"Fatigability and cardiorespiratory impairments in Parkinson\u2019s disease: potential non-motor barriers to activity performance","volume-title":"JFMK","author":"Pechstein","year":"2020"},{"key":"2023120205435861700_CIT0032","first-page":"76","article-title":"Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disability","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Vestergaard","year":"2009"},{"key":"2023120205435861700_CIT0033","first-page":"1236","article-title":"Aerobic capacity and fatigability are associated with activity levels in women with hip osteoarthritis","volume-title":"J Orthop Res.","author":"Foucher","year":"2021"},{"key":"2023120205435861700_CIT0034","first-page":"111172","article-title":"Jump power, leg press power, leg strength and grip strength differentially associated with physical performance: the Developmental Epidemiologic Cohort Study (DECOS)","volume-title":"Exp Gerontol.","author":"Winger","year":"2021"},{"key":"2023120205435861700_CIT0035","first-page":"1226","article-title":"The lifestyle interventions and independence for elders study: design and methods","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Fielding","year":"2011"},{"key":"2023120205435861700_CIT0036","first-page":"29","article-title":"Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties","volume-title":"Eur J Appl Physiol.","author":"Reid","year":"2014"},{"key":"2023120205435861700_CIT0037","first-page":"461","article-title":"The relationship between leg power and physical performance in mobility-limited older people","volume-title":"J Am Geriatr Soc.","author":"Bean","year":"2002"},{"key":"2023120205435861700_CIT0038","first-page":"4","article-title":"Skeletal muscle power: a critical determinant of physical functioning in older adults","volume-title":"Exerc Sport Sci Rev.","author":"Reid","year":"2012"},{"key":"2023120205435861700_CIT0039","first-page":"650","article-title":"Exploring how peak leg power and usual gait speed are linked to late-life disability: data from the National Health and Nutrition Examination Survey (NHANES), 1999-2002","volume-title":"Am J Phys Med Rehabil.","author":"Kuo","year":"2006"},{"key":"2023120205435861700_CIT0040","first-page":"25","article-title":"Slowing down: age-related neurobiological predictors of processing speed","volume-title":"Front Neurosci.","author":"Eckert","year":"2011"},{"key":"2023120205435861700_CIT0041","first-page":"1","article-title":"Relationship between perceived fatigue and performance fatigability in people with multiple sclerosis: a systematic review and meta-analysis","volume-title":"J Psychosom Res.","author":"Loy","year":"2017"},{"key":"2023120205435861700_CIT0042","first-page":"1395","article-title":"Perceived versus performance fatigability in patients with rheumatoid arthritis","volume-title":"Front Physiol.","author":"Marrelli","year":"2018"},{"key":"2023120205435861700_CIT0043","first-page":"2247","article-title":"The relevance of sex differences in performance fatigability","volume-title":"Med Sci Sports Exerc.","author":"Hunter","year":"2016"},{"key":"2023120205435861700_CIT0044","first-page":"1429","article-title":"Mechanical work accounts for sex differences in fatigue during repeated sprints","volume-title":"Eur J Appl Physiol.","author":"Billaut","year":"2012"},{"key":"2023120205435861700_CIT0045","first-page":"243","article-title":"Effect of gender on fatigue and recovery following maximal intensity repeated sprint performance","volume":"50","author":"Laurent","year":"2010","journal-title":"J Sports Med Phys Fitness."},{"key":"2023120205435861700_CIT0046","first-page":"146","article-title":"Mechanisms for the age-related increase in fatigability of the knee extensors in old and very old adults","volume-title":"J Appl Physiol.","author":"Sundberg","year":"2018"},{"key":"2023120205435861700_CIT0047","first-page":"2414","article-title":"Sex differences in human skeletal muscle fatigue are eliminated under ischemic conditions","volume-title":"J Appl Physiol.","author":"Russ","year":"2003"},{"key":"2023120205435861700_CIT0048","first-page":"957","article-title":"Central fatigue explains sex differences in muscle fatigue and contralateral cross-over effects of maximal contractions","volume-title":"Pflugers Arch.","author":"Martin","year":"2007"},{"key":"2023120205435861700_CIT0049","first-page":"1965","article-title":"Innervation and neuromuscular control in ageing skeletal muscle","volume-title":"J Physiol (Lond).","author":"Hepple","year":"2016"},{"key":"2023120205435861700_CIT0050","first-page":"R378","article-title":"Impact of age on exercise-induced ATP supply during supramaximal plantar flexion in humans","volume-title":"Am J Physiol Regul Integr Comp Physiol.","author":"Layec","year":"2015"},{"key":"2023120205435861700_CIT0051","first-page":"13926","article-title":"Associations of gait speed, cadence, gait stability ratio, and body balance with falls in older adults","volume-title":"Int J Environ Res Public Health.","author":"Nascimento","year":"2022"},{"key":"2023120205435861700_CIT0052","first-page":"1010","article-title":"Physical fatigue affects gait characteristics in older persons","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Helbostad","year":"2007"},{"key":"2023120205435861700_CIT0053","first-page":"56","article-title":"Effects of muscle fatigue on gait characteristics under single and dual-task conditions in young and older adults","volume-title":"J Neuroeng Rehabil.","author":"Granacher","year":"2010"},{"key":"2023120205435861700_CIT0054","first-page":"972","article-title":"Reliability of the 400-m usual-pace walk test as an assessment of mobility limitation in older adults","volume-title":"J Am Geriatr Soc.","author":"Rolland","year":"2004"},{"key":"2023120205435861700_CIT0055","first-page":"668","article-title":"Accelerometer test-retest reliability by data processing algorithms: results from the Twin Cities Walking Study","volume-title":"J Phys Act Health.","author":"Sirard","year":"2011"}],"container-title":["The Journals of Gerontology: Series A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glad197\/51513156\/glad197.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/78\/12\/2387\/53973463\/glad197.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/78\/12\/2387\/53973463\/glad197.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T05:44:29Z","timestamp":1701495869000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/78\/12\/2387\/7241400"}},"subtitle":[],"editor":[{"given":"Lewis A","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"(Medical Sciences Section)"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glad197","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,8,11]]}}}