{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:36:12Z","timestamp":1784208972477,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100016913","name":"MSDAVENIR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Understanding the relationship between blood nutrients and neurodegeneration could contribute to devising strategies for preventing Alzheimer\u2019s disease. We investigated the associations between fatty acids, vitamins D, B6, B12, folate, homocysteine, and the cerebral load of amyloid \u03b2 (A\u03b2). This cross-sectional study included 177 older adults (70\u201396 years, 65% female) with objective cognitive impairment, prefrail, or frail. Cerebral A\u03b2 load was determined using positron emission tomography Standardized Uptake Value ratios. Fatty acids were assessed in erythrocytes, vitamins D and homocysteine in serum, and the other vitamins in plasma. Linear regression models corrected for multiple comparisons evaluated the associations between each nutrient and A\u03b2. The principal component factor followed by linear regression grouped the fatty acids strongly correlated (factor) and associated with A\u03b2. Higher concentrations of polyunsaturated fatty acids (PUFAs): clupanodonic acid (22:5n-3; \u03b2: \u22120.13; p\u2005=\u2005.001), mead acid (20:3n-9; \u03b2: \u22120.07; p\u2005=\u2005.036), and adrenic acid (22:4n-6; \u03b2: \u22120.05; p\u2005=\u2005.031) were associated with lower global A\u03b2 load, whereas linoleic acid (18:2n-6) was associated with higher global A\u03b2 load (\u03b2: 0.18; p\u2005=\u2005.042). Clupanodonic acid was inversely associated with A\u03b2 in all cerebral regions except the thalamus. The factor composed of mead, clupanodonic, and arachidonic (20:4n-6) acids was associated with a lower global A\u03b2 load (\u03b2: \u22120.02; p\u2005=\u2005.002). Some erythrocyte PUFAs were inversely associated with A\u03b2 load in the brain, and most of them were metabolites of the essential fatty acids linoleic and \u03b1-linolenic. Given the cross-sectional design, these results must be carefully interpreted, and longitudinal studies are needed.<\/jats:p>","DOI":"10.1093\/gerona\/glad248","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:38:00Z","timestamp":1698277080000},"source":"Crossref","is-referenced-by-count":7,"title":["Associations Between Blood Nutritional Biomarkers and Cerebral Amyloid-\u03b2: Insights From the COGFRAIL Cohort Study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-5869","authenticated-orcid":false,"given":"Natasha A","family":"Grande de Fran\u00e7a","sequence":"first","affiliation":[{"name":"G\u00e9rontop\u00f4le of Toulouse, Institute on Aging, Toulouse University Hospital (CHU de Toulouse) , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Research Institute on Nutrition, Genetics, and Metabolism, School of Medicine, Universidad El Bosque , Bogot\u00e1 , Colombia"},{"name":"Research in Colombia Foundation , Bogot\u00e1 , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Lengel\u00e9","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le of Toulouse, Institute on Aging, Toulouse University Hospital (CHU de Toulouse) , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Soriano","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, La Cit\u00e9 de la Sant\u00e9, H\u00f4pital La Grave , Toulouse , France"},{"name":"Maintain Aging Research team, CERPOP, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Caspar-Bauguil","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie Nutritionnelle, IFB, Toulouse University Hospital (CHU de Toulouse) , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Saint-Aubert","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Pierre-Paul Riquet Hospital, Purpan Toulouse University Hospital , Toulouse , France"},{"name":"ToNIC lab INSERM UMR1214, University Toulouse III Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Payoux","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Pierre-Paul Riquet Hospital, Purpan Toulouse University Hospital , Toulouse , France"},{"name":"ToNIC lab INSERM UMR1214, University Toulouse III Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-1128","authenticated-orcid":false,"given":"Laure","family":"Rouch","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le of Toulouse, Institute on Aging, Toulouse University Hospital (CHU de Toulouse) , Toulouse , France"},{"name":"Maintain Aging Research team, CERPOP, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le of Toulouse, Institute on Aging, Toulouse University Hospital (CHU de Toulouse) , Toulouse , France"},{"name":"Maintain Aging Research team, CERPOP, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le of Toulouse, Institute on Aging, Toulouse University Hospital (CHU de Toulouse) , Toulouse , France"},{"name":"Maintain Aging Research team, CERPOP, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Sourdet","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, La Cit\u00e9 de la Sant\u00e9, H\u00f4pital La Grave , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"2023122103445367900_CIT0001","first-page":"102205","article-title":"The role of peripheral fatty acids as biomarkers for Alzheimer\u2019s disease and brain inflammation","volume-title":"Prostaglandins Leukot Essent Fatty 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