{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:10:16Z","timestamp":1793211016196,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multimorbidity is the simultaneous presence of 2 or more chronic conditions. Metabolomics could identify biomarkers potentially related to multimorbidity. We aimed to identify groups of biomarkers and their association with different multimorbidity patterns. Cross-sectional analyses were conducted within the Seniors-ENRICA-2 cohort in Spain, with information from 700 individuals aged \u226565 years. Biological samples were analyzed using high-throughput proton nuclear magnetic resonance metabolomics. Biomarker groups were identified with exploratory factor analysis, and multimorbidity was classified into 3 types: cardiometabolic, neuropsychiatric, and musculoskeletal. Logistic regression was used to estimate the association between biomarker groups and multimorbidity patterns, after adjusting for potential confounders including sociodemographics, lifestyle, and body mass index. Three factors were identified: the \u201clipid metabolism\u201d mainly reflected biomarkers related to lipid metabolism, such as very-low-density lipoprotein and low-density lipoprotein cholesterol; the \u201chigh-density lipoprotein cholesterol\u201d mainly included high-density lipoprotein cholesterol subclasses and other lipids not included in the first factor; and the \u201camino acid\/glycolysis\/ketogenesis,\u201d composed of some amino acids, glycolysis-related metabolites, and ketone bodies. Higher scores in the \u201clipid metabolism\u201d factor were associated with a higher likelihood of cardiometabolic multimorbidity, odds ratio for tertile 3 versus tertile 1 was 1.79 (95% confidence interval: 1.17\u20132.76). The \u201chigh-density lipoprotein cholesterol\u201d factor was associated with lower odds of cardiometabolic multimorbidity [0.51 (0.32\u20130.82)], and the \u201camino acid\/glycolysis\/ketogenesis\u201d factor was associated with more frequent cardiometabolic multimorbidity [1.85 (1.18\u20132.90)].<\/jats:p>\n                  <jats:p>Different metabolomic biomarkers are associated with different multimorbidity patterns; therefore, multiple biomarker measurements are needed for a complete picture of the molecular mechanisms of multimorbidity.<\/jats:p>","DOI":"10.1093\/gerona\/glad249","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T04:33:14Z","timestamp":1698381194000},"source":"Crossref","is-referenced-by-count":11,"title":["Cross-sectional Association Between Plasma Biomarkers and Multimorbidity Patterns in Older Adults"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-2888","authenticated-orcid":false,"given":"Aitana","family":"V\u00e1zquez-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-8805","authenticated-orcid":false,"given":"Alberto","family":"Lana","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine and Health Sciences, Universidad de Oviedo\/ISPA , Oviedo , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-9616","authenticated-orcid":false,"given":"Ellen A","family":"Struijk","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-756X","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Vega-Cabello","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"C\u00e1rdenas-Valladolid","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n T\u00e9cnica de Sistemas de Informaci\u00f3n, Gerencia Asistencial de Atenci\u00f3n Primaria, Servicio Madrile\u00f1o de Salud, Fundaci\u00f3n de Investigaci\u00f3n e Innovaci\u00f3n Biosanitaria de Atenci\u00f3n Primaria , Madrid , Spain"},{"name":"Enfermer\u00eda, Universidad Alfonso X El Sabio , Villanueva de la Ca\u00f1ada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Salinero-Fort","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n General de Investigaci\u00f3n Sanitaria, Consejer\u00eda de Sanidad, Fundaci\u00f3n de Investigaci\u00f3n e Innovaci\u00f3n Biosanitaria de Atenci\u00f3n Primaria , Madrid , Spain"},{"name":"Red de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas, Grupo de Envejecimiento y Fragilidad de las personas mayores, IdIPAZ , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez-Artalejo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health) , Madrid , Spain"},{"name":"IMDEA-Food Institute, CEI UAM+CSIC , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-4970","authenticated-orcid":false,"given":"Esther","family":"Lopez-Garcia","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"CIBERESP (CIBER of Epidemiology and Public Health) , Madrid , Spain"},{"name":"IMDEA-Food Institute, CEI UAM+CSIC , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9609-3579","authenticated-orcid":false,"given":"Francisco F\u00e9lix","family":"Caballero","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid , Madrid , Spain"},{"name":"CIBERESP (CIBER of Epidemiology and 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