{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:55:36Z","timestamp":1785452136679,"version":"3.56.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization","award":["2021B1212040007"],"award-info":[{"award-number":["2021B1212040007"]}]},{"DOI":"10.13039\/501100004024","name":"Jinan University","doi-asserted-by":"publisher","award":["JNU1AF-CFTP-2022-a01235"],"award-info":[{"award-number":["JNU1AF-CFTP-2022-a01235"]}],"id":[{"id":"10.13039\/501100004024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects in Guangzhou","award":["202201020054"],"award-info":[{"award-number":["202201020054"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2023A03J1032"],"award-info":[{"award-number":["2023A03J1032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous researchers have tried to explore the association between folate\/folic acid intake and dementia incidence, but the results remain controversial. We evaluated the associations of folate\/folic acid supplementation alone and in combination with other B vitamins on dementia risk and brain structure. A total of 466\u2005224 UK Biobank participants were investigated. Cox proportional hazards models were used to assess the associations between folate\/folic acid supplementation status and the risk of Alzheimer\u2019s disease (AD) and vascular dementia (VD). Multivariable linear regression models were employed to evaluate the association between folate\/folic acid supplementation status and brain structure. In the final model, folate\/folic acid supplementation alone was significantly associated with a higher risk of AD (hazard ratio [HR]\u2005=\u20051.34, 95% confidence interval [CI]\u2005=\u20051.06\u20131.69, p\u2005=\u2005.015) and VD (HR\u2005=\u20051.61, 95% CI\u2005=\u20051.21\u20132.13, p\u2005=\u2005.001). Folate\/folic acid supplementation alone was associated with a reduction in the hippocampus (\u03b2\u2005=\u2005\u221295.25 mm3, 95% CI\u2005=\u2005\u2212165.31 to \u221225.19 mm3, p\u2005=\u2005.014) and amygdala (\u03b2\u2005=\u2005\u221251.85 mm3, 95% CI\u2005=\u2005\u221288.02 to \u221215.68 mm3, p\u2005=\u2005.012). The risk of AD and VD, as well as brain structure, in the group with combined folate\/folic acid supplementation and other B vitamins did not show a statistically significant difference compared to the reference group (all p\u2005&amp;gt;\u2005.05). Folate\/folic acid supplementation alone is significantly associated with a higher risk of AD and VD, as well as adverse alterations in brain structure. However, when combined with other B vitamins, these detrimental effects can be counteracted.<\/jats:p>","DOI":"10.1093\/gerona\/glad266","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T19:48:30Z","timestamp":1701287310000},"source":"Crossref","is-referenced-by-count":12,"title":["Associations of Folate\/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants"],"prefix":"10.1093","volume":"79","author":[{"given":"Yitong","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Neurology, Jinan University First Affiliated Hospital , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan University First Affiliated Hospital , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaxuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan University First Affiliated Hospital , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyuan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan University First Affiliated Hospital , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Nursing, Jinan University , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anding","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan University First Affiliated Hospital , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-8771","authenticated-orcid":false,"given":"Jun","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Jinan University First Affiliated Hospital , Guangzhou, Guangdong ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"2025021207411837300_CIT0001","first-page":"413","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume-title":"Lancet","author":"Livingston","year":"2020"},{"key":"2025021207411837300_CIT0002","first-page":"1006","article-title":"Nutrition and prevention of cognitive impairment","volume-title":"Lancet 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