{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:59:18Z","timestamp":1753876758691,"version":"3.41.2"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A1A01071537"],"award-info":[{"award-number":["2020R1I1A1A01071537"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Skeletal muscle and bone interact with each other in mechanical and biochemical ways. This study aimed to investigate the molecular mechanisms of interaction between muscle and bone by analyzing the transcriptional profiles of total RNA from the muscle tissue of females with distal radius fractures. A total of 30 female participants (mean age 71.1\u2005\u00b1\u20058.9 years) with distal radius fractures were recruited. Participants were categorized into 2 groups: the NORM group consisted of participants with T score of the areal bone mineral density (aBMD) of the femoral neck higher than \u20131.0, handgrip strength greater than 18\u00a0kg, and gait speed faster than 1.0 m\/s (n\u2005=\u200510). Otherwise, participants with T score of the aBMD of the femoral neck equal to or less than \u20131.0, handgrip strength lower than 18\u00a0kg, and gait speed slower than 1.0 m\/s (n\u2005=\u200520) were categorized into EXP group. Pronator quadratus muscle samples were obtained from all participants. Total RNA was extracted from frozen muscle samples and sequenced. The gene ontology analysis demonstrated that the potential interactions between attached muscle function and the density of the associated bone would be linked with collagen biosynthetic activity and maintenance of extracellular matrix structures. The analysis of the pathway, network, and protein class exhibited that integrin signaling, inflammatory reactions, matrix metalloproteinase (MMP) activity, and extracellular matrix protein structure had possible associations with the molecular background of muscle\u2013bone interaction. Through integrin signaling, MMP activity, inflammatory reactions, and collagen biosynthesis, muscle and bone may mutually interact with one another.<\/jats:p>","DOI":"10.1093\/gerona\/glae002","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T05:36:00Z","timestamp":1704519360000},"source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional Profiling of Muscle in Females With Distal Radius Fracture and Functional Sarcopenia"],"prefix":"10.1093","volume":"79","author":[{"given":"Jeong-Hyun","family":"Kang","sequence":"first","affiliation":[{"name":"Clinic of Oral Medicine and Orofacial Pain, Institute of Oral Health Science, Ajou University School of Medicine , Suwon, Gyeonggi-do , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hwa","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University , Gwanak-gu, Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Kwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine , Jongno-gu, Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Woo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine , Jongno-gu, Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"2024030719475899400_CIT0001","first-page":"585644","article-title":"Bone and muscle crosstalk in aging","volume-title":"Front Cell Dev Biol.","author":"He","year":"2020"},{"key":"2024030719475899400_CIT0002","first-page":"212","article-title":"Use it or lose it to age: a review of bone and muscle 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