{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:46:00Z","timestamp":1785321960581,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009600"],"award-info":[{"award-number":["2022YFC2009600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009605"],"award-info":[{"award-number":["2022YFC2009605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973133"],"award-info":[{"award-number":["81973133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University","award":["2017J009"],"award-info":[{"award-number":["2017J009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The association between vitamin D and dementia risk in those with prediabetes remains uncertain. We aimed to evaluate the association of serum 25-hydroxyvitamin D (25OHD) with incident dementia among older adults with prediabetes, and examine whether apolipoprotein E (APOE) genotypes, vitamin D receptor (VDR), and vitamin-D-binding protein (VDBP) gene polymorphisms may modify this association.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 34\u00a0237 participants aged \u226560 with prediabetes (HbA1c &amp;lt;6.5% and \u22655.7%) and without dementia at baseline were included from the UK Biobank. Serum 25-hydroxyvitamin D (25OHD) was measured using chemiluminescent immunoassay method. The primary outcome was incident all-cause dementia. Secondary outcomes included incident Alzheimer\u2019s disease (AD) and vascular dementia, respectively. The VDR and VDBP gene polymorphisms included single nucleotide polymorphisms of rs7975232, rs1544410, rs2228570, rs731236, and rs7041, rs4588, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During a median follow-up of 11.8 years, 941 (2.7%) participants developed incident all-cause dementia. Overall, serum 25OHD was inversely associated with all-cause dementia (per standard deviation increment, adjusted hazard ratio: 0.82; 95% confidence interval: 0.75, 0.89). Similar trends were found for incident AD and vascular dementia. Furthermore, there was a stronger inverse relationship between serum 25OHD and all-cause dementia among VDR rs7975232 C allele noncarriers (p-interaction\u2005&amp;lt;\u20050.05). However, APOE \u01904, other VDR, and VDBP gene polymorphisms did not significantly modify the relation of serum 25OHD with incident all-cause dementia (all p-interactions &amp;gt;.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There was an inverse association between serum 25OHD and incident dementia among older adults with prediabetes, especially in VDR rs7975232 AA allele carriers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae015","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T22:21:48Z","timestamp":1704925308000},"source":"Crossref","is-referenced-by-count":6,"title":["Serum 25-Hydroxyvitamin D, Vitamin D Receptor, and Vitamin-D-Binding Protein Gene Polymorphisms and Risk of Dementia Among Older Adults With Prediabetes"],"prefix":"10.1093","volume":"79","author":[{"given":"Chun","family":"Zhou","sequence":"first","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"He","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-7982","authenticated-orcid":false,"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research , Guangzhou 510515 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"2024030816554635200_CIT0001","first-page":"2279","article-title":"Prediabetes: a high-risk state for diabetes development","volume-title":"Lancet.","author":"Tab\u00e1k","year":"2012"},{"key":"2024030816554635200_CIT0002","first-page":"848","article-title":"Prediabetes: moving away from a glucocentric definition","volume-title":"Lancet Diabetes Endocrinol.","author":"Vas","year":"2017"},{"key":"2024030816554635200_CIT0003","first-page":"1388","article-title":"Global prevalence of prediabetes","volume-title":"Diabetes Care.","author":"Rooney","year":"2023"},{"key":"2024030816554635200_CIT0004","first-page":"2074","article-title":"Hearing impairment and incident dementia: findings from The English Longitudinal Study of Ageing","volume-title":"J Am Geriatr 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meta-analysis","volume-title":"Adv Nutr.","author":"Liu","year":"2021"},{"key":"2024030816554635200_CIT0020","first-page":"1898","article-title":"Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes","volume-title":"JAMA.","author":"Levin","year":"2012"},{"key":"2024030816554635200_CIT0021","first-page":"414","article-title":"Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates A \u03b2, tau, immunity and lipid processing","volume-title":"Nat Genet.","author":"Kunkle","year":"2019"},{"key":"2024030816554635200_CIT0022","first-page":"895","article-title":"Apolipoprotein E genotypes and longevity across dementia disorders","volume-title":"Alzheimers Dement","author":"Skillb\u00e4ck","year":"2018"},{"key":"2024030816554635200_CIT0023","first-page":"309","article-title":"Mechanisms of vascular complications in prediabetes","volume-title":"Med Clin North Am.","author":"Milman","year":"2011"},{"key":"2024030816554635200_CIT0024","first-page":"114041","article-title":"Dysfunctional cerebrovascular tone contributes to cognitive impairment in a non-obese rat model of prediabetic challenge: role of suppression of autophagy and modulation by anti-diabetic drugs","volume-title":"Biochem Pharmacol.","author":"Fakih","year":"2020"},{"key":"2024030816554635200_CIT0025","first-page":"1220","article-title":"L6H21 protects against cognitive impairment and brain pathologies via toll-like receptor 4-myeloid differentiation factor 2 signalling in prediabetic rats","volume-title":"Br J Pharmacol.","author":"Oo","year":"2022"},{"key":"2024030816554635200_CIT0026","first-page":"1135","article-title":"The vasculature in prediabetes","volume-title":"Circ Res.","author":"Wasserman","year":"2018"},{"key":"2024030816554635200_CIT0027","first-page":"3147","article-title":"Vitamin D, vitamin D-binding proteins, and VDR polymorphisms in individuals with hyperglycaemia","volume-title":"Nutrients","author":"Erasmus","year":"2022"},{"key":"2024030816554635200_CIT0028","first-page":"e1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume-title":"PLoS Med.","author":"Sudlow","year":"2015"},{"key":"2024030816554635200_CIT0029","first-page":"e0162388","article-title":"Algorithms for the capture and adjudication of prevalent and incident diabetes in UK biobank","volume-title":"PLoS One.","author":"Eastwood","year":"2016"},{"key":"2024030816554635200_CIT0030","first-page":"440","article-title":"Glycated hemoglobin, prediabetes, and the links to cardiovascular disease: data from UK biobank","volume-title":"Diabetes Care.","author":"Welsh","year":"2020"},{"key":"2024030816554635200_CIT0031","first-page":"76","article-title":"A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing","volume-title":"Mol Psychiatry.","author":"Davies","year":"2014"},{"key":"2024030816554635200_CIT0032","first-page":"511","article-title":"Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants","volume-title":"Age Ageing.","author":"Lyall","year":"2016"},{"key":"2024030816554635200_CIT0033","first-page":"1422","article-title":"Midlife vascular risk factors and risk of incident dementia: longitudinal cohort and Mendelian randomization analyses in the UK Biobank","volume-title":"Alzheimers Dement.","author":"Malik","year":"2021"},{"key":"2024030816554635200_CIT0034","first-page":"586","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association\u2019s strategic impact goal through 2020 and beyond","volume-title":"Circulation.","author":"Lloyd-Jones","year":"2010"},{"key":"2024030816554635200_CIT0035","first-page":"1038","article-title":"Identifying dementia cases with routinely collected health data: a systematic review","volume-title":"Alzheimers Dement","author":"Wilkinson","year":"2018"},{"key":"2024030816554635200_CIT0036","first-page":"557","article-title":"Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data","volume-title":"Eur J Epidemiol.","author":"Wilkinson","year":"2019"},{"key":"2024030816554635200_CIT0037","first-page":"1911","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline","volume-title":"J Clin Endocrinol Metab.","author":"Holick","year":"2011"},{"key":"2024030816554635200_CIT0038","first-page":"21","article-title":"Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain","volume-title":"J Chem Neuroanat.","author":"Eyles","year":"2005"},{"key":"2024030816554635200_CIT0039","first-page":"603","article-title":"Developmental vitamin D deficiency alters learning in C57Bl\/6J mice","volume-title":"Behav Brain Res.","author":"Fernandes de Abreu","year":"2010"},{"key":"2024030816554635200_CIT0040","first-page":"703","article-title":"1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer\u2019s disease patients","volume-title":"J Alzheimers Dis.","author":"Masoumi","year":"2009"},{"key":"2024030816554635200_CIT0041","first-page":"207","article-title":"A novel perspective for Alzheimer\u2019s disease: vitamin D receptor suppression by amyloid-\u03b2 and preventing the amyloid-\u03b2 induced alterations by vitamin D in cortical neurons","volume-title":"J Alzheimers Dis.","author":"Dursun","year":"2011"},{"key":"2024030816554635200_CIT0042","first-page":"319","article-title":"Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS","volume-title":"Ann N Y Acad 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