{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:28:53Z","timestamp":1774801733697,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31NS127520"],"award-info":[{"award-number":["F31NS127520"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["3P01AG003949"],"award-info":[{"award-number":["3P01AG003949"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The CUNY Graduate Center Dissertation Fellowship"},{"name":"Leonard and Sylvia Marx Foundation"},{"name":"Czap Foundation"},{"name":"Hollander Family Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Motoric cognitive risk syndrome (MCR) is a predementia condition that combines slow gait speed and subjective cognitive concerns (SCC). The SCC criterion is presently unstandardized, possibly limiting risk detection. We sought to (a) characterize SCC practices through MCR literature review; (b) investigate the ability of SCC in slow gait individuals in predicting the likelihood of cognitive impairment in a demographically diverse sample of community-dwelling, nondemented older adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>First, we comprehensively reviewed the MCR literature, extracting information regarding SCC measures, items, sources, and cognitive domain. Next, Einstein Aging Study (EAS) participants (N\u2005=\u2005278, Mage\u2005=\u200577.22\u2005\u00b1\u20054.74, %female\u2005=\u200567, Meducation\u2005=\u200515\u2005\u00b1\u20053.61, %non-Hispanic White\u2005=\u200546.3) completed gait, Clinical Dementia Rating Scale (CDR), and SCC assessment at baseline and annual follow-up (Mfollow-up\u2005=\u20053.5). Forty-two participants met slow gait criteria at baseline. Generalized linear mixed-effects models examined baseline SCC to predict cognitive impairment on CDR over follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We reviewed all published MCR studies (N\u2005=\u2005106) and documented ambiguity in SCC criteria, with a prevalent approach being use of a single self-reported memory item. In EAS, high SCC endorsement on a comprehensive, validated screen significantly affected the rate of cognitive impairment (CDR; \u03b2interaction\u2005=\u20050.039, p\u2005=\u2005.018) in slow gait individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>An assessment approach that queries across numerous SCC domains was found to predict future decline in clinical dementia status in slow gait older adults. Current SCC practices in MCR, which tend to utilize a single-memory item, may not be the optimal approach. We discuss the implications of SCC criteria validation and standardization to enhance early dementia detection in MCR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae038","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T17:41:31Z","timestamp":1707846091000},"source":"Crossref","is-referenced-by-count":10,"title":["\u201cCognitive\u201d Criteria in Older Adults With Slow Gait Speed: Implications for Motoric Cognitive Risk Syndrome"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-2786","authenticated-orcid":false,"given":"Caroline O","family":"Nester","sequence":"first","affiliation":[{"name":"Department of Psychology, The Graduate Center, City University of New York , New York, New York , USA"},{"name":"Department of Psychology, Queens College, City University of New York , Flushing, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Public Health, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Public Health, Albert Einstein College of Medicine , Bronx, New York , USA"},{"name":"The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy J","family":"Katz","sequence":"additional","affiliation":[{"name":"The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Public Health, Albert Einstein College of Medicine , Bronx, New York , USA"},{"name":"The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-2547","authenticated-orcid":false,"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[{"name":"The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"},{"name":"Department of Medicine (Geriatrics), Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A","family":"Rabin","sequence":"additional","affiliation":[{"name":"Department of Psychology, The Graduate Center, City University of New York , New York, New York , USA"},{"name":"Department of Psychology, Brooklyn College, City University of New York , Brooklyn, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"2024031609220702900_CIT0001","first-page":"412","article-title":"Motoric cognitive risk syndrome and the risk of dementia","volume-title":"J Gerontol A Biol Sci Med Sci.","author":"Verghese","year":"2013"},{"key":"2024031609220702900_CIT0002","first-page":"2278","article-title":"Motoric cognitive risk 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induced hyperinsulinemia in Alzheimer\u2019s disease","volume-title":"Neurobiol Aging.","author":"Craft","year":"1996"},{"key":"2024031609220702900_CIT0043","volume-title":"Symbol Digit Modalities Test, Western Psychological Services Los Angeles","author":"Smith","year":"1973"},{"key":"2024031609220702900_CIT0044","first-page":"676","article-title":"Free and cued selective reminding test: MOANS norms","volume-title":"J Clin Exp Neuropsychol.","author":"Ivnik","year":"1997"},{"key":"2024031609220702900_CIT0045","first-page":"e2338534","article-title":"Motoric cognitive risk and incident dementia in older adults","volume-title":"JAMA Netw Open.","author":"Chung","year":"2023"},{"key":"2024031609220702900_CIT0046","first-page":"S63","article-title":"Subjective cognitive decline in older adults: an overview of self-report measures used across 19 international research studies","volume-title":"J Alzheimers 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