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Sarcopenia is the major component of frailty and is characterized by the gradual loss of muscle mass, strength, and function with age. Inflammaging is the gradual increase in inflammatory status during aging, and it disrupts immune tolerance, causes physiological changes in tissues, organs, and normal cells, and is related to frailty and sarcopenia. The gut microbiota is an extremely complex and diverse microbial community that coevolves with the host. The composition and structure of the gut microbiota and the metabolism of tryptophan (Trp) significantly change in older adults with frailty and sarcopenia. The gut microbiota participates in regulating the Trp metabolic pathways of kynurenine (Kyn), 5-hydroxytryptamine (5-HT), and indole in the gastrointestinal tract. The Trp metabolites derived from the gut microbiota may synergistically promote the occurrence of age-related frailty and sarcopenia by promoting inflammation in the intestines, nervous system, and muscles. The role and mechanisms of the gut microbiota, Trp metabolism, and inflammaging in age-related frailty and sarcopenia may be a worthwhile research direction to help promote healthy aging.<\/jats:p>","DOI":"10.1093\/gerona\/glae044","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T01:04:06Z","timestamp":1707872646000},"source":"Crossref","is-referenced-by-count":27,"title":["Effect of Gut Microbiota-Mediated Tryptophan Metabolism on Inflammaging in Frailty and Sarcopenia"],"prefix":"10.1093","volume":"79","author":[{"given":"YuShuang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YouJun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Central Hospital Affiliated to ShanDong First Medical University , Jinan , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XingSi","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CuiPing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoYu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University , Qingdao, Shandong , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"2024031114130923900_CIT0001","first-page":"1376","article-title":"Management of frailty: Opportunities, challenges, and future directions","volume-title":"Lancet.","author":"Dent","year":"2019"},{"key":"2024031114130923900_CIT0002","first-page":"101737","article-title":"Frailty biomarkers under the perspective of geroscience: A narrative review","volume-title":"Ageing Res Rev.","author":"Gon\u00e7alves","year":"2022"},{"key":"2024031114130923900_CIT0003","first-page":"348","article-title":"Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty","volume-title":"Nat Aging.","author":"Luo","year":"2022"},{"key":"2024031114130923900_CIT0004","first-page":"42","article-title":"Sarcopenia, frailty and their prevention by exercise","volume-title":"Free Radic Biol Med.","author":"Nascimento","year":"2019"},{"key":"2024031114130923900_CIT0005","first-page":"53","article-title":"Frailty and sarcopenia","volume-title":"Orthogeriatrics. 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