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There is an unmet need not only to understand the mechanisms that drive sarcopenia but also to identify novel therapeutic strategies. Given the ease and affordability of husbandry, along with advances in genomics, genome editing technologies, and imaging capabilities, teleost models are increasingly used for aging and sarcopenia research. Here, we explain how teleost species such as zebrafish, African turquoise killifish, and medaka recapitulate many of the classical hallmarks of sarcopenia, and discuss the various dietary, pharmacological, and genetic approaches that have been used in teleosts to understand the mechanistic basis of sarcopenia.<\/jats:p>","DOI":"10.1093\/gerona\/glae052","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T13:39:57Z","timestamp":1708090797000},"source":"Crossref","is-referenced-by-count":3,"title":["Skeletal Muscle Aging: Lessons From Teleosts"],"prefix":"10.1093","volume":"80","author":[{"given":"Tuyen K","family":"Quach","sequence":"first","affiliation":[{"name":"Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan F","family":"Taylor","sequence":"additional","affiliation":[{"name":"Australian Regenerative Medicine Institute, Monash University , Clayton, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D","family":"Currie","sequence":"additional","affiliation":[{"name":"Australian Regenerative Medicine Institute, Monash University , Clayton, Victoria ,","place":["Australia"]},{"name":"EMBL Australia, Victorian Node, Monash University , Clayton, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-8276","authenticated-orcid":false,"given":"Nir","family":"Eynon","sequence":"additional","affiliation":[{"name":"Australian Regenerative Medicine Institute, Monash University , Clayton, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-0079","authenticated-orcid":false,"given":"Avnika A","family":"Ruparelia","sequence":"additional","affiliation":[{"name":"Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Australian Regenerative Medicine Institute, Monash University , Clayton, Victoria , (Biological Sciences Section)","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"2025060705251884300_CIT0001","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal muscle: a brief review of structure and function","volume-title":"Calcif Tissue Int.","author":"Frontera","year":"2015"},{"key":"2025060705251884300_CIT0002","doi-asserted-by":"publisher","first-page":"155560","DOI":"10.1016\/j.metabol.2023.155560","article-title":"Epidemiology of 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