{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:00:42Z","timestamp":1753876842723,"version":"3.41.2"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["JP20K16524","JP21H03200","JP21K07522","JP21K11725","JP21K10448","JP22K07421","JP22K17396","JP23K09692","JP23K09717","JP23K16330","JP23K06787","JP23K09060"],"award-info":[{"award-number":["JP20K16524","JP21H03200","JP21K07522","JP21K11725","JP21K10448","JP22K07421","JP22K17396","JP23K09692","JP23K09717","JP23K16330","JP23K06787","JP23K09060"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan","award":["JPMH23FA1006","JPMH23FA1022"],"award-info":[{"award-number":["JPMH23FA1006","JPMH23FA1022"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23dk0207053","JP23km0405209"],"award-info":[{"award-number":["JP23dk0207053","JP23km0405209"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1\u00a0201 community-dwelling Japanese aged \u226565 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV\/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV\/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction\u2005&amp;lt;\u2005.05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.<\/jats:p>","DOI":"10.1093\/gerona\/glae075","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T06:49:56Z","timestamp":1709707796000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study"],"prefix":"10.1093","volume":"79","author":[{"given":"Naoki","family":"Hirabayashi","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-344X","authenticated-orcid":false,"given":"Jun","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-9636","authenticated-orcid":false,"given":"Yoshihiko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University , Iwate , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9006-5937","authenticated-orcid":false,"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"},{"name":"Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"2024040811195666500_CIT0001","first-page":"448","article-title":"Measuring the global burden of disease","volume-title":"N Engl J Med.","author":"Murray","year":"2013"},{"key":"2024040811195666500_CIT0002","first-page":"253","article-title":"Heart failure and risk of dementia: A Danish nationwide population-based cohort study","volume-title":"Eur J Heart 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Heart J.","author":"Frey","year":"2021"},{"key":"2024040811195666500_CIT0007","first-page":"e1054","article-title":"Role of biomarkers for the prevention, assessment, and management of heart failure: A scientific statement from the American Heart Association","volume-title":"Circulation.","author":"Chow","year":"2017"},{"key":"2024040811195666500_CIT0008","first-page":"2129","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume-title":"Eur Heart J.","author":"Ponikowski","year":"2016"},{"key":"2024040811195666500_CIT0009","first-page":"840","article-title":"Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis","volume-title":"Lancet Diabetes Endocrinol.","author":"Natriuretic Peptides Studies","year":"2016"},{"key":"2024040811195666500_CIT0010","first-page":"1007","article-title":"NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up","volume-title":"J Alzheimers Dis.","author":"Tynkkynen","year":"2015"},{"key":"2024040811195666500_CIT0011","first-page":"356","article-title":"The N-terminal pro B-type natriuretic peptide, and risk of dementia and cognitive decline: A 10-year follow-up study in the general population","volume-title":"J Neurol Neurosurg Psychiatry.","author":"Mirza","year":"2016"},{"key":"2024040811195666500_CIT0012","first-page":"e011652","article-title":"NT-proBNP and risk of dementia in a general Japanese elderly population: The Hisayama Study","volume-title":"J Am Heart Assoc","author":"Nagata","year":"2019"},{"key":"2024040811195666500_CIT0013","first-page":"813","article-title":"N-terminal pro-brain natriuretic peptide and abnormal brain aging: The AGES-Reykjavik Study","volume-title":"Neurology.","author":"Sabayan","year":"2015"},{"key":"2024040811195666500_CIT0014","first-page":"2246","article-title":"Cardiac and crotid markers link with accelerated brain atrophy: The AGES-Reykjavik Study (Age, Gene\/Environment Susceptibility-Reykjavik)","volume-title":"Arterioscler Thromb Vasc Biol.","author":"Sabayan","year":"2016"},{"key":"2024040811195666500_CIT0015","first-page":"205","article-title":"N-Terminal pro-B-Type natriuretic peptide and subclinical brain damage in the general population","volume-title":"Radiology.","author":"Zonneveld","year":"2017"},{"key":"2024040811195666500_CIT0016","first-page":"307","article-title":"N-Terminal pro-brain natriuretic peptide and associations with brain magnetic resonance imaging (MRI) features in middle age: The CARDIA Brain MRI Study","volume-title":"Front Neurol.","author":"Ferguson","year":"2018"},{"key":"2024040811195666500_CIT0017","first-page":"e014659","article-title":"Growth differentiation factor 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volume on brain magnetic resonance imaging in elderly Japanese: The Hisayama Study","volume-title":"Circ J.","author":"Yamasaki","year":"2020"},{"key":"2024040811195666500_CIT0026","first-page":"107","article-title":"Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay","volume-title":"Clin Chim Acta.","author":"Yeo","year":"2003"},{"key":"2024040811195666500_CIT0027","first-page":"2997","article-title":"N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: The Hisayama Study","volume-title":"Arterioscler Thromb Vasc Biol.","author":"Doi","year":"2011"},{"key":"2024040811195666500_CIT0028","first-page":"32","article-title":"Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: Accuracy and use for population estimates","volume-title":"Am J Kidney Dis.","author":"Horio","year":"2010"},{"key":"2024040811195666500_CIT0029","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987","edition":"3"},{"key":"2024040811195666500_CIT0030","first-page":"1133","article-title":"Practice parameter: early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the quality standards subcommittee of the American Academy of Neurology","volume-title":"Neurology.","author":"Petersen","year":"2001"},{"key":"2024040811195666500_CIT0031","first-page":"263","article-title":"Multiple-region gray matter atrophy as a predictor for the development of dementia in a community: The Hisayama Study","volume-title":"J Neurol Neurosurg Psychiatry.","author":"Nakazawa","year":"2022"},{"key":"2024040811195666500_CIT0032","first-page":"289","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume-title":"J R Stat Soc B (Methodol)","author":"Benjamini","year":"1995"},{"key":"2024040811195666500_CIT0033","first-page":"1037","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume-title":"Stat Med.","author":"Desquilbet","year":"2010"},{"key":"2024040811195666500_CIT0034","first-page":"331","article-title":"Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer\u2019s pathogenesis","volume-title":"Neurobiol Aging.","author":"de la Torre","year":"2000"},{"key":"2024040811195666500_CIT0035","first-page":"367516","article-title":"Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia","volume-title":"Cardiovasc Psychiatry Neurol","author":"de la Torre","year":"2012"},{"key":"2024040811195666500_CIT0036","first-page":"1294","article-title":"Reduced regional cerebral blood flow in patients with heart failure","volume-title":"Eur J Heart Fail.","author":"Roy","year":"2017"},{"key":"2024040811195666500_CIT0037","first-page":"e018203","article-title":"N-terminal pro brain, N-terminal pro atrial natriuretic peptides, and dynamic cerebral autoregulation","volume-title":"J Am Heart Assoc","author":"Mahinrad","year":"2020"},{"key":"2024040811195666500_CIT0038","first-page":"406","article-title":"Heart failure and Alzheimer\u2019s disease","volume-title":"J Intern Med.","author":"Cermakova","year":"2015"},{"key":"2024040811195666500_CIT0039","first-page":"441","article-title":"Hemodynamic and serum cardiac markers and risk of cognitive impairment and dementia","volume-title":"Alzheimers Dement","author":"van der Velpen","year":"2017"},{"key":"2024040811195666500_CIT0040","first-page":"e000222","article-title":"Clinical prediction of incident heart failure risk: A systematic review and meta-analysis","volume-title":"Open Heart","author":"Yang","year":"2015"},{"key":"2024040811195666500_CIT0041","first-page":"781","article-title":"Association between type 2 diabetes mellitus and brain atrophy: A meta-analysis","volume-title":"Diabetes Metab J","author":"Zhang","year":"2022"},{"key":"2024040811195666500_CIT0042","first-page":"637","article-title":"Higher blood pressure is associated with greater white matter lesions and brain atrophy: A systematic review with meta-analysis","volume-title":"J Clin Med","author":"Alateeq","year":"2021"},{"key":"2024040811195666500_CIT0043","first-page":"625","article-title":"The human hippocampus and spatial and episodic memory","volume-title":"Neuron.","author":"Burgess","year":"2002"},{"key":"2024040811195666500_CIT0044","first-page":"279","article-title":"The medial temporal lobe","volume-title":"Annu Rev Neurosci.","author":"Squire","year":"2004"},{"key":"2024040811195666500_CIT0045","first-page":"781","article-title":"Antisaccades: A probe into the dorsolateral prefrontal cortex in Alzheimer\u2019s disease. A critical review","volume-title":"J Alzheimers Dis.","author":"Kaufman","year":"2010"},{"key":"2024040811195666500_CIT0046","first-page":"223","article-title":"Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community","volume-title":"Neurol Clin Pract","author":"Yubi","year":"2018"}],"container-title":["The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glae075\/56901160\/glae075.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/79\/5\/glae075\/57180819\/glae075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/79\/5\/glae075\/57180819\/glae075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:20:05Z","timestamp":1712575205000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/doi\/10.1093\/gerona\/glae075\/7624029"}},"subtitle":[],"editor":[{"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"(Biological Sciences Section)"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glae075","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"type":"print","value":"1079-5006"},{"type":"electronic","value":"1758-535X"}],"subject":[],"published-other":{"date-parts":[[2024,5,1]]},"published":{"date-parts":[[2024,3,7]]},"article-number":"glae075"}}