{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:00:40Z","timestamp":1787238040290,"version":"build-2736575974"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014184","name":"R\u00e9gion Occitanie Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","doi-asserted-by":"publisher","award":["1901175"],"award-info":[{"award-number":["1901175"]}],"id":[{"id":"10.13039\/501100014184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MP0022856"],"award-info":[{"award-number":["MP0022856"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"G\u00e9rontop\u00f4le of Toulouse"},{"name":"French Ministry of Health"},{"DOI":"10.13039\/501100020910","name":"European Lead Factory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020910","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ExonHit Therapeutics SA"},{"name":"Avid Radiopharmaceuticals Inc"},{"DOI":"10.13039\/501100006556","name":"Centre Hospitalier Universitaire de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association Monegasque pour la Recherche sur la maladie d\u2019Alzheimer"},{"name":"the INSERM-University of Toulouse III UMR 1295 Research Unit"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease is strongly linked to metabolic abnormalities. We aimed to distinguish amyloid-positive people who progressed to cognitive decline from those who remained cognitively intact. We performed untargeted metabolomics of blood samples from amyloid-positive individuals, before any sign of cognitive decline, to distinguish individuals who progressed to cognitive decline from those who remained cognitively intact. A plasma-derived metabolite signature was developed from Supercritical Fluid chromatography coupled with high-resolution mass spectrometry (SFC-HRMS) and nuclear magnetic resonance (NMR) metabolomics. The 2 metabolomics data sets were analyzed by Data Integration Analysis for Biomarker discovery using Latent approaches for Omics studies (DIABLO), to identify a minimum set of metabolites that could describe cognitive decline status. NMR or SFC-HRMS data alone cannot predict cognitive decline. However, among the 320 metabolites identified, a statistical method that integrated the 2 data sets enabled the identification of a minimal signature of 9 metabolites (3-hydroxybutyrate, citrate, succinate, acetone, methionine, glucose, serine, sphingomyelin d18:1\/C26:0 and triglyceride C48:3) with a statistically significant ability to predict cognitive decline more than 3 years before decline. This metabolic fingerprint obtained during this exploratory study may help to predict amyloid-positive individuals who will develop cognitive decline. Due to the high prevalence of brain amyloid-positivity in older adults, identifying adults who will have cognitive decline will enable the development of personalized and early interventions.<\/jats:p>","DOI":"10.1093\/gerona\/glae077","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T15:16:36Z","timestamp":1709824596000},"source":"Crossref","is-referenced-by-count":13,"title":["Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults"],"prefix":"10.1093","volume":"79","author":[{"given":"Marie","family":"Tremblay-Franco","sequence":"first","affiliation":[{"name":"Toxalim (Research Center in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS , Toulouse , France"},{"name":"Metatoul-AXIOM Platform, MetaboHUB, Toxalim, INRAE , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Canlet","sequence":"additional","affiliation":[{"name":"Toxalim (Research Center in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS , Toulouse , France"},{"name":"Metatoul-AXIOM Platform, MetaboHUB, Toxalim, INRAE , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Carriere","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Nakhle","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Galinier","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"},{"name":"Institut F\u00e9d\u00e9ratif de Biologie, CHU Purpan , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Portais","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"},{"name":"MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse Biotechnology Institute , INSA de Toulouse INSA\/CNRS 5504 - UMR INSA\/INRA 792,Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Yart","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Dray","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Hsuan","family":"Lu","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bertrand Michel","sequence":"additional","affiliation":[{"name":"Lipidomic, MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics , Toulouse , France"},{"name":"I2MC, Universit\u00e9 de Toulouse, Inserm, Universit\u00e9 Toulouse III - Paul Sabatier (UPS) , Toulouse , France (Biological Sciences Section)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Delrieu","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe de Souto","family":"Barreto","sequence":"additional","affiliation":[{"name":"G\u00e9rontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse) , Toulouse , France"},{"name":"CERPOP UMR 1295, University of Toulouse III, INSERM, UPS , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"P\u00e9nicaud","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Casteilla","sequence":"additional","affiliation":[{"name":"Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Universit\u00e9 Paul Sabatier , Toulouse , 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