{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T04:07:15Z","timestamp":1754021235704,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG035009","P30 AG028747","R21 HD043269","R01 AG029315","R37 AG09901"],"award-info":[{"award-number":["R01 AG035009","P30 AG028747","R21 HD043269","R01 AG029315","R37 AG09901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"United States Department of Veterans Affairs Rehabilitation R&D (Rehab RD) Service"},{"name":"Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatric Research, Education and Clinical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Mechanistic factors on the pathway to improving independent ambulatory ability among hip fracture patients by a multicomponent home-based physical therapy intervention that emphasized aerobic, strength, balance, and functional training are unknown. The aim of this study was to determine the effects of 2 different home-based physical therapy programs on muscle area and attenuation (reflects muscle density) of the lower extremities, bone mineral density (BMD), and aerobic capacity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Randomized controlled trial of home-based 16 weeks of strength, endurance, balance, and function exercises (PUSH, n\u2005=\u200519) compared to seated active range-of-motion exercises and transcutaneous electrical neurostimulation (PULSE, n\u2005=\u200518) in community-dwelling adults &amp;gt;60 years of age within 26 weeks of hip fracture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In PUSH and PULSE groups combined, the fractured leg had lower muscle area and muscle attenuation and higher subcutaneous fat than the nonfractured leg (p\u2005&amp;lt;\u2005.001) at baseline. At 16 weeks, mean muscle area of the fractured leg was higher in the PUSH than PULSE group (p\u2005=\u2005.04). Changes in muscle area were not significantly different when compared to the comparative PULSE group. There was a clinically relevant difference in change in femoral neck BMD between groups (p\u2005=\u2005.05) that showed an increase after PULSE and decrease after PUSH. There were generally no between-group differences in mean VO2peak tests at 16-week follow-up, except the PUSH group reached a higher max incline (p\u2005=\u2005.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The treatment effects of a multicomponent home-based physical therapy intervention on muscle composition, BMD, and aerobic capacity were not significantly different than an active control intervention in older adults recovering from hip fracture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial Registration<\/jats:title>\n                  <jats:p>ClinicalTrials.gov Identifier: NCT01783704<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae078","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T18:54:15Z","timestamp":1709837655000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of Multicomponent Home-Based Intervention on Muscle Composition, Fitness, and Bone Density After Hip Fracture"],"prefix":"10.1093","volume":"79","author":[{"given":"Alice S","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Medicine, Baltimore VAMC, University of Maryland School of Medicine , Baltimore, Maryland , USA"},{"name":"Geriatric Research, Education and Clinical Center (GRECC), VA Maryland Health Care System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brock A","family":"Beamer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Medicine, Baltimore VAMC, University of Maryland School of Medicine , Baltimore, Maryland , USA"},{"name":"Geriatric Research, Education and Clinical Center (GRECC), VA Maryland Health Care System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-1973","authenticated-orcid":false,"given":"Ann L","family":"Gruber-Baldini","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L","family":"Craik","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Health Sciences, Arcadia University , Glenside, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Golden","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc C","family":"Hochberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, UMSOM and Medical Care Clinical Center, VA Maryland Health Care System , Baltimore, Maryland , USA"},{"name":"Department of Epidemiology and Public Health, UMSOM and Medical Care Clinical Center, VA Maryland Health Care System , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen K","family":"Mangione","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Health Sciences, Arcadia University , Glenside, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Orwig","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M","family":"Rathbun","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Magaziner","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine , Baltimore, Maryland , 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