{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:36:20Z","timestamp":1776479780977,"version":"3.51.2"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG057548-01A1"],"award-info":[{"award-number":["1R01AG057548-01A1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["PO1 AG03949"],"award-info":[{"award-number":["PO1 AG03949"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Czap Foundation"},{"name":"Leonard and Sylvia Marx Foundation"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-62842"],"award-info":[{"award-number":["MOP-62842"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de Recherche du Quebec","award":["2020-VICO-279753"],"award-info":[{"award-number":["2020-VICO-279753"]}]},{"DOI":"10.13039\/100013228","name":"Quebec Network for Research on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013228","id-type":"DOI","asserted-by":"publisher"}]},{"name":"La Fondation de l\u2019Universit\u00e9 de Sherbrooke"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Motoric Cognitive Risk (MCR) syndrome, a predementia syndrome characterized by cognitive complaints and slow gait, may have an underlying vascular etiology. Elevated blood levels of homocysteine, a known vascular risk factor, have been linked to physical and cognitive decline in older adults, though the relationship with MCR is unknown. We aimed to identify the association between homocysteine and MCR risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We examined the association between baseline homocysteine levels and incident MCR using Cox proportional hazard models in 1826 community-dwelling older adults (55% women) from 2 cohorts (Einstein Aging Study [EAS] and Quebec Longitudinal Study on Nutrition and Successful Aging [NuAge]). We calculated hazard ratios (HR) with 95% confidence intervals (CI), for each cohort as well as stratified by sex and vascular disease\/risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Median follow-up time was 2.2 years in EAS and 3.0 years in NuAge. Individuals with elevated baseline homocysteine levels (&amp;gt;14 \u00b5mol\/L) had a significantly higher risk of incident MCR compared to those with normal levels in NuAge (HR 1.41, 95% CI: 1.01\u20131.97, p\u2005=\u2005.04), after adjusting for covariates. Our exploratory stratified analyses found that these associations were significant only in men with vascular disease\/risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Higher blood homocysteine levels are associated with an increased risk of developing MCR in older adults, particularly in men with vascular disease or vascular risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae114","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T04:39:33Z","timestamp":1714192773000},"source":"Crossref","is-referenced-by-count":3,"title":["Elevated Blood Homocysteine Increases the Risk of Incident Motoric Cognitive Risk Syndrome: A Two-Cohort Study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9014-9762","authenticated-orcid":false,"given":"Kelly","family":"Cotton","sequence":"first","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmeline","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Population Health, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-4830","authenticated-orcid":false,"given":"Olivier","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Research Centre of the Geriatric University Institute of Montreal , Montreal, Quebec , Canada"},{"name":"Department of Medicine, Faculty of Medicine, University of Montreal , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A","family":"Derby","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"},{"name":"Department of Epidemiology & Population Health, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"},{"name":"Department of Epidemiology & Population Health, Albert Einstein College of Medicine , Bronx, New York , 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Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-2547","authenticated-orcid":false,"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine , Bronx, New York , USA"},{"name":"Department of Medicine, Albert Einstein College of Medicine , Bronx, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"issue":"4","key":"2024060713062785600_CIT0001","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/gerona\/gls191","article-title":"Motoric cognitive risk syndrome and the risk of dementia","volume":"68","author":"Verghese","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"8","key":"2024060713062785600_CIT0002","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1212\/WNL.0000000000000717","article-title":"Motoric 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