{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:52:23Z","timestamp":1789627943422,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007024"],"award-info":[{"award-number":["T32 HL007024"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG054693"],"award-info":[{"award-number":["K01AG054693"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01 AG080122"],"award-info":[{"award-number":["K01 AG080122"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01 AG076967"],"award-info":[{"award-number":["K01 AG076967"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG057545"],"award-info":[{"award-number":["U01 AG057545"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Daily physical activity patterns differ by Alzheimer\u2019s disease (AD) status and might signal cognitive risk. It is critical to understand whether patterns are disrupted early in the AD pathological process. Yet, whether established AD risk markers (\u03b2-amyloid [A\u03b2] or apolipoprotein E-\u03b54 [APOE-\u03b54]) are associated with differences in objectively measured activity patterns among cognitively unimpaired older adults is unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Wrist accelerometry, brain A\u03b2 (+\/\u2212), and APOE-\u03b54 genotype were collected in 106 (A\u03b2) and 472 (APOE-\u03b54) participants (mean age 76 [standard deviation{SD}: 8.5) or 75 [SD: 9.2] years, 60% or 58% women) in the Baltimore Longitudinal Study of Aging. Adjusted linear and function-on-scalar regression models examined whether A\u03b2 or APOE-\u03b54 status was cross-sectionally associated with activity patterns (amount, variability, or fragmentation) overall and by time of day, respectively. Differences in activity patterns by combinations of A\u03b2 and APOE-\u03b54 status were descriptively examined (n\u2005=\u2005105).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were no differences in any activity pattern by A\u03b2 or APOE-\u03b54 status overall. A\u03b2+ was associated with lower total amount and lower within-day variability of physical activity overnight and early evening, and APOE-\u03b54 carriers had higher total amount of activity in the evening and lower within-day variability of activity in the morning. Diurnal curves of activity were blunted among those with A\u03b2+ regardless of APOE-\u03b54 status, but only when including older adults with mild cognitive impairment\/dementia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A\u03b2+ in cognitively unimpaired older adults might manifest as lower amount and variability of daily physical activity, particularly during overnight\/evening hours. Future research is needed to examine changes in activity patterns in larger samples and by other AD biomarkers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae119","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T11:10:13Z","timestamp":1715685013000},"source":"Crossref","is-referenced-by-count":8,"title":["Differences in Daily Physical Activity by Alzheimer\u2019s Risk Markers Among Older Adults"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-052X","authenticated-orcid":false,"given":"Francesca R","family":"Marino","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"},{"name":"Center on Aging & Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , 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National Institute on Aging , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-1613","authenticated-orcid":false,"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Intramural Research Program, National Institute on Aging , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-0995","authenticated-orcid":false,"given":"Adam P","family":"Spira","sequence":"additional","affiliation":[{"name":"Center on Aging & Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"},{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-5184","authenticated-orcid":false,"given":"Amal 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