{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:03:46Z","timestamp":1784631826294,"version":"3.55.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaison Committee for Education, Research, and Innovation in Central Norway","award":["2022-30545"],"award-info":[{"award-number":["2022-30545"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liaison Committee for Education, Research, and Innovation in Central Norway"},{"name":"Joint Research Committee between St. Olavs Hospital and the Faculty of Medicine and Health Sciences"},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["U54AG063546\u00d0"],"award-info":[{"award-number":["U54AG063546\u00d0"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["P30AG066508\u00d0"],"award-info":[{"award-number":["P30AG066508\u00d0"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R61 AG069822\u00d0"],"award-info":[{"award-number":["R61 AG069822\u00d0"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["RF1AG058545\u00d0"],"award-info":[{"award-number":["RF1AG058545\u00d0"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["P30AG021342\u00d0"],"award-info":[{"award-number":["P30AG021342\u00d0"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["U19AI089992\u00d0"],"award-info":[{"award-number":["U19AI089992\u00d0"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["R01AI142624\u00d0"],"award-info":[{"award-number":["R01AI142624\u00d0"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"publisher","award":["UL1TR001863\u00d0"],"award-info":[{"award-number":["UL1TR001863\u00d0"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>High blood pressure and poor cardiorespiratory fitness are independent risk factors for dementia. However, few studies have examined if combined longitudinal patterns of these modifiable risk factors are associated with dementia risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this prospective cohort study, we used data from the population-based Tr\u00f8ndelag Health (HUNT) Study, Norway. We applied group-based multidimensional trajectory modeling to identify age-specific multidimensional trajectories of SBP, DBP, and estimated cardiorespiratory fitness across 3 surveys (HUNT1, 1984\u20131986 to HUNT3, 2006\u20132008). Dementia was diagnosed in the HUNT4 70+ substudy in 2017\u20132019. We used multivariate logistic regression to estimate odds ratios (ORs) and risk differences (RDs) of dementia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 7\u00a0594 participants (54.9% women) were included, with a mean age of 44.7 (SD 6.3) years at HUNT1. Dementia was diagnosed in 1\u00a0062 (14.0%) participants. We identified 2 multidimensional trajectories throughout adulthood within 3 age groups: one with higher systolic blood pressure (SBP) and diastolic blood pressure (DBP), and lower estimated cardiorespiratory fitness (the poorer group), and one with lower SBP and DBP, and higher cardiorespiratory fitness (the better group). After adjustment for sex, apolipoprotein E \u03b54 status, education, marital status, and diabetes, the better group had consistently lower risk of dementia in all age groups with the lowest OR in the middle-aged group of 0.63 (95% confidence intervals [95% CI]: 0.51, 0.78) with corresponding RD of \u22120.07 (95% CI: \u22120.10, \u22120.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Having a beneficial multidimensional trajectory of SBP, DBP, and cardiorespiratory fitness in adulthood was associated with reduced dementia risk. Aiming for optimal SBP, DBP, and estimated cardiorespiratory fitness throughout adulthood may reduce dementia risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae161","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:45:06Z","timestamp":1718779506000},"source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study"],"prefix":"10.1093","volume":"79","author":[{"given":"Maren","family":"Lerfald","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Science, Department of Public Health and Nursing, Norwegian University of Science and Technology , Trondheim , Norway"},{"name":"Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-8175","authenticated-orcid":false,"given":"Heather","family":"Allore","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale School of Medicine, Yale University , New Haven, Connecticut , USA"},{"name":"Department of Biostatistics, Yale School of Public Health, Yale University , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom I L","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science, Department of Public Health and Nursing, Norwegian University of Science and Technology , Trondheim , Norway"},{"name":"Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rannveig S","family":"Eldholm","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim , Norway"},{"name":"Faculty of Medicine and Health Science, Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-9960","authenticated-orcid":false,"given":"Nicolas","family":"Martinez-Velilla","sequence":"additional","affiliation":[{"name":"Navarrabiomed, Hospital Universitario de Navarra, UPNA, IdiSNA , Pamplona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Selb\u00e6k","sequence":"additional","affiliation":[{"name":"Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust , Oslo , Norway"},{"name":"Department of Geriatric Medicine, Oslo University Hospital , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Ernstsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science, Department of Public Health and Nursing, Norwegian University of Science and Technology , Trondheim , Norway"},{"name":"Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"2024072408305056100_CIT0001","volume-title":"Global Action Plan on the Public Health Response to Dementia 2017\u20132025","author":"Organization WH","year":"2017"},{"issue":"2","key":"2024072408305056100_CIT0002","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 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