{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:30Z","timestamp":1792790430883,"version":"4.5.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2021xkjT038"],"award-info":[{"award-number":["2021xkjT038"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2022xkfyhz09"],"award-info":[{"award-number":["2022xkfyhz09"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201026"],"award-info":[{"award-number":["82201026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alveolar bone loss is generally considered a chronological age-related disease. As biological aging process is not absolutely determined by increasing age, whether alveolar bone loss is associated with increasing chronological age or biological aging remains unclear. Accurately distinguishing whether alveolar bone loss is chronological age-related or biological aging-related is critical for selecting appropriate clinical treatments. This study aimed to identify the relationship between alveolar bone loss and body aging. In total, 3\u00a0635 participants from the National Health and Nutrition Examination Survey and 71 living kidney transplant recipients from Gene Expression Omnibus Datasets were enrolled. Multivariate regression analysis, smooth curve fittings, and generalized additive models were used to explore the association among alveolar bone loss, age, serum \u03b1-Klotho level, renal function markers, as well as between preoperative creatinine and renal cortex-related \u03b1-Klotho gene expression level. Meanwhile, a 2-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between \u03b1-Klotho and periodontal disease (4\u2009376 individuals vs 361\u2009194 individuals). As a biological aging-related indicator, the \u03b1-Klotho level was negatively correlated with impaired renal function and alveolar bone loss. Correspondingly, accompanied by decreasing renal function, it was manifested with a downregulated expression level of \u03b1-Klotho in the renal cortex and aggravated alveolar bone loss. The MR analysis further identified the negative association between higher genetically predicted \u03b1-Klotho concentrations with alveolar bone loss susceptibility using the IVW (odds ratio [OR]\u2005=\u20050.999, p\u2005=\u2005.005). However, an inversely U-shaped association was observed between chronological age and alveolar bone loss, which is especially stable in men (the optimal cutoff values were both 62 years old). For men above 62 years old, increasing age is converted to protective factor and is accompanied by alleviated alveolar bone loss. Alveolar bone loss that is directly associated with decreased renal function and \u03b1-Klotho level was related to biological aging rather than chronological age. The renal\u2013alveolar bone axis could provide a new sight of clinical therapy in alveolar bone loss.<\/jats:p>","DOI":"10.1093\/gerona\/glae172","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T15:16:04Z","timestamp":1720797364000},"source":"Crossref","is-referenced-by-count":11,"title":["Deciphering the Biological Aging Impact on Alveolar Bone Loss: Insights From \u03b1-Klotho and Renal Function Dynamics"],"prefix":"10.1093","volume":"79","author":[{"given":"Zifei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First Affiliated Hospital of Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First Affiliated Hospital of Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-8348","authenticated-orcid":false,"given":"Hengguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University , Hefei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"issue":"Suppl 21","key":"2024081705513234300_CIT0001","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jcpe.13049","article-title":"Cell therapy for orofacial bone regeneration: a systematic review and meta-analysis","volume":"46","author":"Shanbhag","year":"2019","journal-title":"J Clin Periodontol."},{"key":"2024081705513234300_CIT0002","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/prd.12368","article-title":"Maintaining homeostatic control of periodontal bone 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