{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:38:19Z","timestamp":1772138299620,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32HD107806"],"award-info":[{"award-number":["F32HD107806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03AG073929"],"award-info":[{"award-number":["R03AG073929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS121191"],"award-info":[{"award-number":["R01NS121191"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG073676"],"award-info":[{"award-number":["R21AG073676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008270","name":"Lantheus Medical Imaging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Normal aging is associated with significant deleterious cerebrovascular changes; these have been implicated in disease pathogenesis and increased susceptibility to ischemic injury. Although these changes are well documented in the brain, few studies have been conducted in the spinal cord. Here, we utilize specialized contrast-enhanced ultrasound (CEUS) imaging to investigate age-related changes in cervical spinal vascular anatomy and hemodynamics in male Fisher 344 rats, a common strain in aging research. Aged rats (24\u201326 months, N\u2005=\u20056) exhibited significant tortuosity in the anterior spinal artery and elevated vascular resistance compared to adults (4\u20136 months, N\u2005=\u20056; tortuosity index 2.20\u2005\u00b1\u20050.15 vs 4.74\u2005\u00b1\u20050.45, p\u2005&amp;lt;\u2005.05). Baseline blood volume was lower in both larger vessels and the microcirculation in the aged cohort, specifically in white matter (4.44e14\u2005\u00b1\u20051.37e13 vs 3.66e14\u2005\u00b1\u20052.64e13 CEUS bolus area under the curve, p\u2005&amp;lt;\u2005.05). To elucidate functional differences, animals were exposed to a hypoxia challenge, whereas adult rats exhibited significant functional hyperemia in both gray matter (GM) and white matter (WM) (GM: 1.13\u2005\u00b1\u20050.10-fold change from normoxia, p\u2005&amp;lt;\u2005.05; WM: 1.16\u2005\u00b1\u20050.13, p\u2005&amp;lt;\u2005.05), aged rats showed no response. Immunohistochemistry revealed reduced pericyte coverage and activated microglia behavior in aged rats, which may partially explain the lack of vascular response. This study provides the first in vivo description of age-related hemodynamic differences in the cervical spinal cord.<\/jats:p>","DOI":"10.1093\/gerona\/glae215","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T04:08:24Z","timestamp":1724731704000},"source":"Crossref","is-referenced-by-count":2,"title":["Contrast-Enhanced Ultrasound Imaging Detects Anatomical and Functional Changes in Rat Cervical Spine Microvasculature With Normal Aging"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-519X","authenticated-orcid":false,"given":"Jennifer N","family":"Harmon","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeja","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abarajithan","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey E","family":"Hyde","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo J","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May J","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatric Medicine, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew F","family":"Bruce","sequence":"additional","affiliation":[{"name":"Applied Physics Laboratory, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-5891","authenticated-orcid":false,"given":"Zin Z","family":"Khaing","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington , Seattle, Washington,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"2025010611005438400_CIT0001","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","article-title":"Review: cerebral microvascular pathology in ageing and neurodegeneration","volume":"37","author":"Brown","year":"2011","journal-title":"Neuropathol Appl Neurobiol."},{"key":"2025010611005438400_CIT0002","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41380-021-01361-1","article-title":"Age-related immune alterations and cerebrovascular inflammation","volume":"27","author":"Finger","year":"2022","journal-title":"Mol Psychiatry."},{"key":"2025010611005438400_CIT0003","doi-asserted-by":"publisher","first-page":"H1124","DOI":"10.1152\/ajpheart.00776.2018","article-title":"Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment","volume":"316","author":"Fulop","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"2025010611005438400_CIT0004","doi-asserted-by":"publisher","first-page":"931536","DOI":"10.3389\/fnagi.2022.931536","article-title":"Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes","volume":"14","author":"Lee","year":"2022","journal-title":"Front Aging Neurosci."},{"key":"2025010611005438400_CIT0005","doi-asserted-by":"publisher","first-page":"557384","DOI":"10.3389\/fnagi.2020.557384","article-title":"Aging of the vascular system and neural diseases","volume":"12","author":"Watanabe","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"2025010611005438400_CIT0006","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/sj.sc.3101489","article-title":"Effects on age on spinal cord lesion patients\u2019 rehabilitation","volume":"41","author":"Scivoletto","year":"2003","journal-title":". Spinal Cord."},{"key":"2025010611005438400_CIT0007","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1093\/gerona\/glad107","article-title":"The brain and spinal microvasculature in normal aging","volume":"78","author":"Khaing","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"2025010611005438400_CIT0008","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1159\/000080173","article-title":"Aging changes of the angioarchitecture and arterial morphology of the spinal cord in rats","volume":"50","author":"Qiu","year":"2004","journal-title":"Gerontology."},{"key":"2025010611005438400_CIT0009","doi-asserted-by":"publisher","first-page":"11235","DOI":"10.3390\/ijms241411235","article-title":"Spinal cord blood vessels in aged mice show greater levels of hypoxia-induced vascular disruption and microglial activation","volume":"24","author":"Halder","year":"2023","journal-title":"Int J Mol Sci."},{"key":"2025010611005438400_CIT0010","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.4103\/1673-5374.360245","article-title":"Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase\/endothelial nitric oxide synthase pathway","volume":"18","author":"Zhao","year":"2023","journal-title":"Neural Regen Res"},{"key":"2025010611005438400_CIT0011","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jneumeth.2010.06.012","article-title":"Characterization of the hemodynamic response in the rat lumbar spinal cord using intrinsic optical imaging and laser speckle","volume":"191","author":"Brieu","year":"2010","journal-title":"J Neurosci Methods."},{"key":"2025010611005438400_CIT0012","doi-asserted-by":"publisher","first-page":"9691","DOI":"10.1038\/srep09691","article-title":"In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury","volume":"5","author":"Tang","year":"2015","journal-title":"Sci Rep."},{"key":"2025010611005438400_CIT0013","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.expneurol.2019.05.010","article-title":"Surgical preparations, labeling strategies, and optical techniques for cell-resolved, in vivo imaging in the mouse spinal cord","volume":"318","author":"Cheng","year":"2019","journal-title":"Exp Neurol."},{"key":"2025010611005438400_CIT0014","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1088\/0031-9155\/58\/11\/R37","article-title":"Optical properties of biological tissues: a review","volume":"58","author":"Jacques","year":"2013","journal-title":"Phys Med Biol."},{"key":"2025010611005438400_CIT0015","doi-asserted-by":"publisher","first-page":"21943","DOI":"10.1038\/s41598-022-24986-w","article-title":"Quantitative tissue perfusion imaging using nonlinear ultrasound localization microscopy","volume":"12","author":"Harmon","year":"2022","journal-title":"Sci Rep."},{"key":"2025010611005438400_CIT0016","doi-asserted-by":"publisher","first-page":"114681","DOI":"10.1016\/j.expneurol.2024.114681","article-title":"Quantifying injury expansion in the cervical spinal cord with intravital ultrafast contrast-enhanced ultrasound imaging","volume":"374","author":"Harmon","year":"2024","journal-title":"Exp Neurol."},{"key":"2025010611005438400_CIT0017","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41598-021-04712-8","article-title":"Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse","volume":"12","author":"Lowerison","year":"2022","journal-title":"Sci Rep."},{"key":"2025010611005438400_CIT0018","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1109\/TUFFC.2020.2986486","article-title":"High-frequency nonlinear Doppler contrast-enhanced ultrasound imaging of blood flow","volume":"67","author":"Bruce","year":"2020","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control."},{"key":"2025010611005438400_CIT0019","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.ultrasmedbio.2022.03.004","article-title":"Blood flow changes associated with spinal cord injury assessed by non-linear Doppler contrast-enhanced ultrasound","volume":"48","author":"Bruce","year":"2022","journal-title":"Ultrasound Med Biol."},{"key":"2025010611005438400_CIT0020","doi-asserted-by":"publisher","first-page":"e0197486","DOI":"10.1371\/journal.pone.0197486","article-title":"Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression","volume":"13","author":"Hassan","year":"2018","journal-title":"PLoS One."},{"key":"2025010611005438400_CIT0021","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1089\/neur.2021.0004","article-title":"Intermittent hypoxia induces greater functional breathing motor recovery as a fixed rather than varied duration treatment after cervical spinal cord injury in rats","volume":"2","author":"Silverstein","year":"2021","journal-title":"Neurotrauma Rep"},{"key":"2025010611005438400_CIT0022","volume-title":"An Augmented Fast Marching Method for Computing Skeletons and Centerlines","author":"Telea","year":"2002"},{"key":"2025010611005438400_CIT0023","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1148\/radiology.190.3.8115639","article-title":"Power Doppler US: a potentially useful alternative to mean frequency-based color Doppler US","volume":"190","author":"Rubin","year":"1994","journal-title":"Radiology."},{"key":"2025010611005438400_CIT0024","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/nmeth.1641","article-title":"Functional ultrasound imaging of the brain","volume":"8","author":"Mac\u00e9","year":"2011","journal-title":"Nat Methods."},{"key":"2025010611005438400_CIT0025","doi-asserted-by":"publisher","first-page":"e20211071","DOI":"10.1084\/jem.20211071","article-title":"Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions","volume":"219","author":"Cs\u00e1sz\u00e1r","year":"2022","journal-title":"J Exp Med."},{"key":"2025010611005438400_CIT0026","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature13165","article-title":"Capillary pericytes regulate cerebral blood flow in health and disease","volume":"508","author":"Hall","year":"2014","journal-title":"Nature."},{"key":"2025010611005438400_CIT0027","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.14336\/AD.2022.1204","article-title":"Emerging links between cerebral blood flow regulation and cognitive decline: a role for brain microvascular pericytes","volume":"14","author":"You","year":"2023","journal-title":"Aging Dis"},{"key":"2025010611005438400_CIT0028","doi-asserted-by":"publisher","first-page":"e22949","DOI":"10.1002\/ajp.22949","article-title":"Age-related changes in myelin of axons of the corpus callosum and cognitive decline in common marmosets","volume":"81","author":"Phillips","year":"2019","journal-title":"Am J Primatol."},{"key":"2025010611005438400_CIT0029","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1111\/cns.13497","article-title":"Demyelinating processes in aging and stroke in the central nervous system and the prospect of treatment strategy","volume":"26","author":"Chen","year":"2020","journal-title":"CNS Neurosci Ther."},{"key":"2025010611005438400_CIT0030","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s11357-020-00172-6","article-title":"Molecular changes associated with spinal cord aging","volume":"42","author":"Piekarz","year":"2020","journal-title":"Geroscience"},{"key":"2025010611005438400_CIT0031","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1134\/S0022093022040172","article-title":"Age-related changes in microglia of the rat spinal cord","volume":"58","author":"Kolos","year":"2022","journal-title":"J Evol Biochem Physiol"},{"key":"2025010611005438400_CIT0032","doi-asserted-by":"publisher","first-page":"B369","DOI":"10.1093\/gerona\/53a.5.b369","article-title":"Decreased axosomatic input to motoneurons and astrogliosis in the spinal cord of aged rats","volume":"53","author":"Kullberg","year":"1998","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"2025010611005438400_CIT0033","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s43587-021-00043-5","article-title":"Healthy aging and the blood-brain barrier","volume":"1","author":"Banks","year":"2021","journal-title":"Nat Aging"},{"key":"2025010611005438400_CIT0034","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","article-title":"The blood-brain barrier in aging and neurodegeneration","volume":"27","author":"Knox","year":"2022","journal-title":"Mol Psychiatry."},{"key":"2025010611005438400_CIT0035","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13195-014-0080-3","article-title":"Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old","volume":"7","author":"Clark","year":"2015","journal-title":"Alzheimers Res Ther"},{"key":"2025010611005438400_CIT0036","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1007\/s11357-023-00790-w","article-title":"A decade of aging in healthy older adults: longitudinal findings on cerebrovascular and cognitive health","volume":"45","author":"Weijs","year":"2023","journal-title":"Geroscience"},{"key":"2025010611005438400_CIT0037","doi-asserted-by":"publisher","first-page":"H1","DOI":"10.1152\/ajpheart.00581.2016","article-title":"Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging","volume":"312","author":"Toth","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"2025010611005438400_CIT0038","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1093\/brain\/awx112","article-title":"Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia","volume":"140","author":"Yew","year":"2017","journal-title":"Brain."},{"key":"2025010611005438400_CIT0039","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s40141-020-00270-8","article-title":"Acute intermittent hypoxia as a potential adjuvant to improve walking following spinal cord injury: evidence, challenges, and future directions","volume":"8","author":"Tan","year":"2020","journal-title":"Curr Phys Med Rehab Rep"},{"key":"2025010611005438400_CIT0040","doi-asserted-by":"publisher","first-page":"113891","DOI":"10.1016\/j.expneurol.2021.113891","article-title":"Therapeutic acute intermittent hypoxia: a translational roadmap for spinal cord injury and neuromuscular disease","volume":"347","author":"Vose","year":"2022","journal-title":"Exp Neurol."},{"key":"2025010611005438400_CIT0041","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1002\/nbm.3026","article-title":"Cerebral blood flow response to acute hypoxic hypoxia","volume":"26","author":"Harris","year":"2013","journal-title":"NMR Biomed."},{"key":"2025010611005438400_CIT0042","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1038\/jcbfm.2012.93","article-title":"Effect of Hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism","volume":"32","author":"Xu","year":"2012","journal-title":"J Cereb Blood Flow Metab."},{"key":"2025010611005438400_CIT0043","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1152\/ajplegacy.1970.218.4.1020","article-title":"Local cerebral blood flow in young and old rats during hypoxia and hypercapnia","volume":"218","author":"Haining","year":"1970","journal-title":"Am J Physiol."},{"key":"2025010611005438400_CIT0044","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/0271678X18818291","article-title":"Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain","volume":"40","author":"Vestergaard","year":"2018","journal-title":"J Cereb Blood Flow Metab."},{"key":"2025010611005438400_CIT0045","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000112845","article-title":"Cellular and molecular events underlying the dysregulated response of the aged brain to stroke: a mini-review","volume":"54","author":"Petcu","year":"2008","journal-title":"Gerontology."},{"key":"2025010611005438400_CIT0046","doi-asserted-by":"publisher","first-page":"584891","DOI":"10.3389\/fphys.2020.584891","article-title":"Cerebrovascular blood flow design and regulation; vulnerability in aging brain","volume":"11","author":"Wilson","year":"2020","journal-title":"Front Physiol."},{"key":"2025010611005438400_CIT0047","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s12031-019-01371-3","article-title":"Age and sex-related changes to gene expression in the mouse spinal cord","volume":"69","author":"McCallum-Loudeac","year":"2019","journal-title":"J Mol Neurosci."},{"key":"2025010611005438400_CIT0048","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s10522-017-9726-4","article-title":"Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state","volume":"18","author":"Nacka-Aleksi\u0107","year":"2017","journal-title":"Biogerontology"},{"key":"2025010611005438400_CIT0049","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1213\/00000539-199112000-00013","article-title":"Cerebral autoregulation in awake versus isoflurane-anesthetized rats","volume":"73","author":"Hoffman","year":"1991","journal-title":"Anesth Analg."},{"key":"2025010611005438400_CIT0050","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s12576-018-0607-7","article-title":"Isoflurane anesthesia does not affect spinal cord neurovascular coupling: evidence from decerebrated rats","volume":"69","author":"Paquette","year":"2019","journal-title":"J Physiol Sci."}],"container-title":["The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/advance-article-pdf\/doi\/10.1093\/gerona\/glae215\/58932276\/glae215.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/80\/1\/glae215\/58932276\/glae215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/80\/1\/glae215\/58932276\/glae215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:01:08Z","timestamp":1736143268000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/doi\/10.1093\/gerona\/glae215\/7742305"}},"subtitle":[],"editor":[{"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,11]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glae215","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.12.584672","asserted-by":"object"}]},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,8,27]]},"article-number":"glae215"}}