{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:49:34Z","timestamp":1790311774609,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Little work to date has quantified the effect of psychotropic medications (antidepressants, benzodiazepines, \u201cZ\u201d drugs, antipsychotics, anticholinergics) on mobility and gait in later life. The aim of this study is to examine the relationship between these medications and mobility\/gait parameters in a large cohort of community-dwelling older people.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants were included if they were aged \u226560 years at TILDA Wave 1 and underwent gait and mobility assessment (Gaitrite system), with follow-up at Wave 3 (4 years). Medication lists were examined for psychotropic medications. Regression models assessed the relationship between psychotropic medications and mobility using the following parameters: Timed Up and Go, gait speed, step length\/width, and double support phase. Multilevel modeling assessed trajectories of mobility\/gait variables over time by psychotropic use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 2620 patients, 12% were prescribed \u22651 psychotropic medication, and 3% prescribed \u22652 psychotropics. Cross-sectionally, psychotropic medication was independently associated with prolonged Timed Up and Go (\u03b2\u2005=\u20050.50 [95% confidence interval {CI} 0.27\u20130.73]; p\u2005&amp;lt;\u2005.001), slower gait speed (\u03b2\u2005=\u2005\u22125.65 [95% CI \u22127.92 to \u22123.38]; p\u2005&amp;lt;\u2005.001), shorter step length (\u03b2\u2005=\u2005\u22122.03 [95% CI \u22122.93 to \u22121.42]; p\u2005&amp;lt;\u2005.001), and increased double support phase (\u03b2\u2005=\u20050.47 [95% CI 0.19\u20130.75]; p\u2005=\u2005.001). Longitudinally, psychotropic use was independently associated with transition to abnormal Timed Up and Go (odds ratio 2.68 [95% CI 1.55\u20134.64], p\u2005&amp;lt;\u2005.001), whereas using \u22652 psychotropics was associated with transition to slower gait speed (odds ratio 2.59 [95% CI 1.01\u20136.68]; p\u2005=\u2005.048).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Psychotropic use was associated with significantly poorer mobility and gait performance, both cross-sectionally and longitudinally. It is imperative that psychotropic medication use is reviewed as part of a comprehensive geriatric assessment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae263","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:43:10Z","timestamp":1730868190000},"source":"Crossref","is-referenced-by-count":8,"title":["The Association Between Psychotropic Medication Use and Gait and Mobility Impairment in Community-Dwelling Older People: Data From The Irish Longitudinal Study on Ageing (TILDA)"],"prefix":"10.1093","volume":"80","author":[{"given":"Desmond","family":"O\u2019 Donnell","sequence":"first","affiliation":[{"name":"Medicine for the Elderly Department, Mercers Institute for Successful Ageing, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"The Irish Longitudinal Study on Ageing, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Moriarty","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, Trinity College Dublin , Dublin,","place":["Ireland"]},{"name":"School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Lavan","sequence":"additional","affiliation":[{"name":"Medicine for the Elderly Department, Mercers Institute for Successful Ageing, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"The Irish Longitudinal Study on Ageing, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"Medicine for the Elderly Department, Mercers Institute for Successful Ageing, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"The Irish Longitudinal Study on Ageing, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-2692","authenticated-orcid":false,"given":"Robert","family":"Briggs","sequence":"additional","affiliation":[{"name":"Medicine for the Elderly Department, Mercers Institute for Successful Ageing, St James\u2019s Hospital , Dublin,","place":["Ireland"]},{"name":"The Irish Longitudinal Study on Ageing, Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"issue":"4","key":"2025042809461403400_CIT0001","doi-asserted-by":"publisher","first-page":"371.e11","DOI":"10.1016\/j.jamda.2017.12.098","article-title":"Fall-risk-increasing drugs: a systematic review and meta-analysis: II. psychotropics","volume":"19","author":"Seppala","year":"2018","journal-title":"J Am Med Dir Assoc."},{"issue":"4","key":"2025042809461403400_CIT0002","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40266-020-00754-1","article-title":"Psychotropic drug-associated pneumonia in older adults","volume":"37","author":"Rajamaki","year":"2020","journal-title":"Drugs Aging"},{"issue":"6","key":"2025042809461403400_CIT0003","doi-asserted-by":"publisher","first-page":"e183750","DOI":"10.1001\/jamanetworkopen.2018.3750","article-title":"Association of focused medication review with optimization of psychotropic drug prescribing","volume":"1","author":"Sheehan","year":"2018","journal-title":"JAMA Netw. 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