{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:40:43Z","timestamp":1790887243478,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Claude D. Pepper Older American Independence Centers","award":["P30AG067988"],"award-info":[{"award-number":["P30AG067988"]}]},{"name":"Royal Perth Hospital Research Foundation"},{"DOI":"10.13039\/501100024253","name":"Future Health Research and Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Biomarkers for sarcopenia are lacking. We examined the diagnostic power of serum creatinine to cystatin C ratio for identifying low magnetic resonance imaging-muscle volume and low grip strength in a large observational study of UK Biobank older adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serum creatinine and cystatin C were measured via immunoassays (Beckman Coulter AU5800 and Siemens Advia 1800, respectively) and grip strength by hydraulic hand dynamometer at baseline visit (2008\u20132010). magnetic resonance imaging-thigh fat-free muscle volume and DXA-derived appendicular lean mass were measured at imaging visit (2014\u20132018). Extreme outliers were removed, and covariates (demographic, lifestyle, and clinical factors, as well as time elapsed between baseline-imaging visit) were adjusted for in statistical models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>12\u2005873 older adults (mean age: 63.5\u2005\u00b1\u20052.7 years, 44.2% women) were included for fat-free muscle volume and appendicular lean mass\/body mass index; 149\u2005707 older adults (mean age: 64.0\u2005\u00b1\u20052.9 years, 50.5% women) for grip strength. Despite significant associations (p\u2005&amp;lt;\u2005.05), in fully adjusted models, creatinine to cystatin C showed poor to acceptable diagnostic power for identifying low fat-free muscle volume when using cutpoints of 20th percentile (area under the curve: 0.577 men; 0.622 women) and T scores of \u22122 (area under the curve: 0.596 men; 0.659 women) and \u22122.5 (area under the curve: 0.609 men; 0.722 women). In fully adjusted model, creatinine to cystatin C showed poor diagnostic power (area under the curves: &amp;lt;0.70) for identifying low appendicular lean mass\/body mass index or low grip strength, irrespective of the cutpoint used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Creatinine to cystatin C may not be a suitable biomarker for identifying low muscle volume or low strength in older adults. This finding, drawn from a large sample size and the use of advanced medical imaging, marks an important contribution to the sarcopenia field.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glae274","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:08:14Z","timestamp":1731564494000},"source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic Power of Serum Creatinine\/Cystatin C Ratio for Identifying Low MRI-Muscle Volume and Low Grip Strength: Data From 9\u2005731 to 149\u2005707 UK Biobank Older Adults"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-776X","authenticated-orcid":false,"given":"Ben","family":"Kirk","sequence":"first","affiliation":[{"name":"Department of Medicine, Western Health, Melbourne Medical School, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-2380","authenticated-orcid":false,"given":"Chia-Ling","family":"Kuo","sequence":"additional","affiliation":[{"name":"The Cato T. 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Laurencin Institute for Translation in Regenerative Engineering, University of Connecticut Health , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-6827","authenticated-orcid":false,"given":"Jesse","family":"Zanker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western Health, Melbourne Medical School, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9388","authenticated-orcid":false,"given":"Konstantinos","family":"Prokopidis","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool , 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