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This study evaluates the relationship between cardiometabolic multimorbidity and dementia onset according to racial\/ethnic group in a nationally representative cohort of U.S. middle-aged and older adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from the Health &amp; Retirement Study (1998\u20132018, N\u2005=\u20057,960, mean baseline age 59.4 years) and discrete-time survival models were used to estimate differences in the risk of dementia onset, defined by Langa\u2013Weir classification. Models included race\/ethnicity (non-Hispanic White, non-Hispanic Black, and Hispanic), chronic disease\/multimorbidity categories (no disease, one disease, cardiovascular multimorbidity, metabolic multimorbidity, cardiometabolic multimorbidity, other multimorbidity), age, sex, education, wealth, body-mass index, and proxy status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Over a mean follow-up of 14.6 years, 7.7% of the participants (n\u2005=\u2005614) developed dementia. In the fully adjusted model, participants with cardiometabolic multimorbidity had the highest risk of dementia onset (HR:3.27, 95%CI: 2.06, 5.21), followed by metabolic (HR:1.83, 95%CI: 1.14, 2.94), and cardiovascular (HR:1.81, 95%CI: 1.24, 2.64) multimorbidity, relative to participants with no disease. The risk of dementia was significantly greater among Black (HR: 6.40, 95% CI: 3.84, 10.67) and Hispanic participants (HR: 4.90, 95% CI: 2.85, 8.43) with cardiometabolic multimorbidity, compared with White adults with no disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Individuals from racial\/ethnic minoritized groups have a higher risk of dementia. The risk of dementia onset was significantly greater for Black and Hispanic participants experiencing cardiometabolic multimorbidity, highlighting the value of intervening in cardiometabolic conditions among middle-aged and older adults, in particular, those from racial\/ethnic minoritized backgrounds to reduce the risk of developing dementia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glaf009","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:23:16Z","timestamp":1736835796000},"source":"Crossref","is-referenced-by-count":7,"title":["Cardiometabolic Multimorbidity and Dementia Onset Among Middle-Aged and Older Adults: Differences by Race\/Ethnicity"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1875-9248","authenticated-orcid":false,"given":"Siting","family":"Chen","sequence":"first","affiliation":[{"name":"OHSU-PSU School of Public Health , Portland, Oregon 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