{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:37:20Z","timestamp":1787805440360,"version":"build-2784847793"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG078530"],"award-info":[{"award-number":["AG078530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The UConn Older Americans Independence Pepper Center","award":["P30AG067988"],"award-info":[{"award-number":["P30AG067988"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heterogeneity in aging is a fundamental biological process arising from multifactorial etiologies, including genetic, lifestyle, and socioeconomic factors. Modeling this heterogeneity in animal systems is critical for elucidating the underlying mechanisms of aging and for leveraging these insights in translational research. Here we present part II, a summary of the model organism research presented at the NIA Heterogeneity and Successful Aging workshop, held in May 2023.<\/jats:p>","DOI":"10.1093\/gerona\/glaf021","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T23:20:26Z","timestamp":1737847226000},"source":"Crossref","is-referenced-by-count":3,"title":["Workshop Report\u2014Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-7465","authenticated-orcid":false,"given":"Vivek","family":"Kumar","sequence":"first","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, Maine ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-4377","authenticated-orcid":false,"given":"Andrea L","family":"Hevener","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles , Los Angeles, California ,","place":["USA"]},{"name":"VA Greater Los Angeles Healthcare System Geriatric Research Education Clinical Center (GRECC) , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Graham","family":"Ruby","sequence":"additional","affiliation":[{"name":"Calico Life Sciences LLC , South San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medical Center , Boston, Massachusetts ,","place":["USA"]},{"name":"School of Medicine, Tufts University , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A","family":"Kuchel","sequence":"additional","affiliation":[{"name":"UConn Center on Aging, University of Connecticut School of Medicine , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Participants of the NIA Heterogeneity and Successful Aging Workshop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozalyn M","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire N","family":"Bedbrook","sequence":"additional","affiliation":[{"name":"Stanford University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Beerman","sequence":"additional","affiliation":[{"name":"National Institute on Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Churchill","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Engelman","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L","family":"Hevener","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Huisingh-Scheetz","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey","family":"Ideker","sequence":"additional","affiliation":[{"name":"University of California-San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Kane","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhoo","family":"Kim","sequence":"additional","affiliation":[{"name":"University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G","family":"Koch","sequence":"additional","affiliation":[{"name":"The University of Toledo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A","family":"Kuchel","sequence":"additional","affiliation":[{"name":"University of Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Graham","family":"Ruby","sequence":"additional","affiliation":[{"name":"Calico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousin","family":"Suh","sequence":"additional","affiliation":[{"name":"Columbia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Thyfault","sequence":"additional","affiliation":[{"name":"The University of Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"2025042109354821900_CIT0001","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1146\/annurev-animal-022114-110829","article-title":"Animal models of aging research: implications for human aging and age-related diseases","volume":"3","author":"Mitchell","year":"2015","journal-title":"Annu Rev Anim Biosci."},{"issue":"4811","key":"2025042109354821900_CIT0002","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.3299702","article-title":"Human aging: usual and successful","volume":"237","author":"Rowe","year":"1987","journal-title":"Science."},{"issue":"5","key":"2025042109354821900_CIT0003","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/geronj\/29.5.555","article-title":"Aging and individual differences: a longitudinal analysis of social, psychological, and physiological indicators","volume":"29","author":"Maddox","year":"1974","journal-title":"J Gerontol"},{"issue":"1","key":"2025042109354821900_CIT0004","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/geront\/32.1.17","article-title":"Aged heterogeneity: fact or fiction? The fate of diversity in gerontological research","volume":"32","author":"Nelson","year":"1992","journal-title":"Gerontologist."},{"issue":"2","key":"2025042109354821900_CIT0005","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/geronb\/gbp102","article-title":"Dynamics and heterogeneity in the process of human frailty and aging: evidence from the U.S. Older Adult Population","volume":"65B","author":"Yang","year":"2010","journal-title":"J Gerontol. Series B, Psychol Sci Soc Sci"},{"issue":"6","key":"2025042109354821900_CIT0006","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1093\/gerona\/glt162","article-title":"Heterogeneity in Healthy Aging","volume":"69","author":"Lowsky","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"2025042109354821900_CIT0007","author":"Workshop: Heterogeneity and Successful Aging"},{"issue":"2","key":"2025042109354821900_CIT0008","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1534\/genetics.111.132597","article-title":"High-resolution genetic mapping using the mouse diversity outbred population","volume":"190","author":"Svenson","year":"2012","journal-title":"Genetics."},{"key":"2025042109354821900_CIT0009","doi-asserted-by":"publisher","DOI":"10.1101\/2023.11.28.568901","article-title":"Regulators of health and lifespan extension in genetically diverse mice on dietary restriction","author":"Francesco","year":"2023"},{"key":"2025042109354821900_CIT0010","doi-asserted-by":"publisher","DOI":"10.1101\/2024.02.06.579096","article-title":"Longitudinal fragility phenotyping","author":"Luciano","year":"2024"},{"key":"2025042109354821900_CIT0011","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-6427-7_1","article-title":"Resources for systems genetics","volume-title":"Systems Genetics","author":"Williams","year":"2017"},{"issue":"1","key":"2025042109354821900_CIT0012","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2156-5-7","article-title":"A new set of BXD recombinant inbred lines from advanced intercross populations in mice","volume":"5","author":"Peirce","year":"2004","journal-title":"BMC Genet."},{"issue":"2","key":"2025042109354821900_CIT0013","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/genetics\/151.2.785","article-title":"Multiple-trait quantitative trait loci analysis using a large mouse sibship","volume":"151","author":"Jackson","year":"1999","journal-title":"Genetics."},{"issue":"8","key":"2025042109354821900_CIT0014","doi-asserted-by":"publisher","first-page":"B358","DOI":"10.1093\/gerona\/54.8.b358","article-title":"Announcement: four-way cross mouse stocks: a new, genetically heterogeneous resource for aging research","volume":"54","author":"Miller","year":"1999","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"9","key":"2025042109354821900_CIT0015","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/s42255-021-00449-w","article-title":"Gene-by-environment modulation of lifespan and weight gain in the murine BXD family","volume":"3","author":"Roy","year":"2021","journal-title":"Nat Metab."},{"issue":"6614","key":"2025042109354821900_CIT0016","doi-asserted-by":"publisher","first-page":"eabo3191","DOI":"10.1126\/science.abo3191","article-title":"Sex- and age-dependent genetics of longevity in a heterogeneous mouse population","volume":"377","author":"Bou Sleiman","year":"2022","journal-title":"Science."},{"issue":"7450","key":"2025042109354821900_CIT0017","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12188","article-title":"Mitonuclear protein imbalance as a conserved longevity mechanism","volume":"497","author":"Houtkooper","year":"2013","journal-title":"Nature."},{"issue":"8","key":"2025042109354821900_CIT0018","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s43587-022-00266-0","article-title":"A machine-vision-based frailty index for mice","volume":"2","author":"Hession","year":"2022","journal-title":"Nat Aging"},{"issue":"6","key":"2025042109354821900_CIT0019","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/gerona\/glt136","article-title":"A clinical frailty index in aging mice: comparisons with frailty index data in humans","volume":"69","author":"Whitehead","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"2","key":"2025042109354821900_CIT0020","doi-asserted-by":"publisher","first-page":"110231","DOI":"10.1016\/j.celrep.2021.110231","article-title":"Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation","volume":"38","author":"Sheppard","year":"2022","journal-title":"Cell Rep"},{"issue":"5","key":"2025042109354821900_CIT0021","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/gerona\/glad035","article-title":"An automated, home-cage, video monitoring-based mouse frailty index detects age-associated morbidity in C57BL\/6 and diversity outbred mice. Anderson RM, ed","volume":"78","author":"Ruby","year":"2023","journal-title":"J Gerontol Ser A."},{"issue":"2","key":"2025042109354821900_CIT0022","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1242\/dmm.023226","article-title":"The short-lived African turquoise killifish: an emerging experimental model for ageing","volume":"9","author":"Kim","year":"2016","journal-title":"Dis Model Mech"},{"issue":"3","key":"2025042109354821900_CIT0023","doi-asserted-by":"publisher","first-page":"e12757","DOI":"10.1111\/acel.12757","article-title":"The African turquoise killifish: a research organism to study vertebrate aging and diapause","volume":"17","author":"Hu","year":"2018","journal-title":"Aging Cell."},{"issue":"6","key":"2025042109354821900_CIT0024","doi-asserted-by":"publisher","first-page":"pdb.prot107917","DOI":"10.1101\/pdb.prot107917","article-title":"Life span assessment in the African Turquoise Killifish Nothobranchius furzeri","volume":"2023","author":"Bedbrook","year":"2023","journal-title":"Cold Spring Harb Protoc"},{"issue":"6","key":"2025042109354821900_CIT0025","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.neuron.2015.11.031","article-title":"Mapping sub-second structure in mouse behavior","volume":"88","author":"Wiltschko","year":"2015","journal-title":"Neuron."},{"issue":"3","key":"2025042109354821900_CIT0026","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/icb\/45.3.405","article-title":"Divergent selection for aerobic capacity in rats as a model for complex disease","volume":"45","author":"Koch","year":"2005","journal-title":"Integr Comp Biol."},{"issue":"1","key":"2025042109354821900_CIT0027","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1152\/physiolgenomics.2001.5.1.45","article-title":"Artificial selection for intrinsic aerobic endurance running capacity in rats","volume":"5","author":"Koch","year":"2001","journal-title":"Physiol Genomics."},{"issue":"1","key":"2025042109354821900_CIT0028","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41514-020-00054-3","article-title":"Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan","volume":"7","author":"Aon","year":"2021","journal-title":"NPJ Aging Mech Dis."},{"issue":"5708","key":"2025042109354821900_CIT0029","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1126\/science.1108177","article-title":"Cardiovascular risk factors emerge after artificial selection for low aerobic capacity","volume":"307","author":"Wisl\u00f8ff","year":"2005","journal-title":"Science."},{"issue":"2","key":"2025042109354821900_CIT0030","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.tcm.2012.06.007","article-title":"A rat model system to study complex disease risks, fitness, aging, and longevity","volume":"22","author":"Koch","year":"2012","journal-title":"Trends Cardiovasc Med."},{"issue":"2","key":"2025042109354821900_CIT0031","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/00005768-199802000-00013","article-title":"Familial resemblance for \u02d9VO2 max in the sedentary state: the HERITAGE family study","volume":"30","author":"Bouchard","year":"1998","journal-title":"Med Sci Sports Exerc."},{"issue":"11","key":"2025042109354821900_CIT0032","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise capacity and mortality among men referred for exercise testing","volume":"346","author":"Myers","year":"2002","journal-title":"N Engl J Med."},{"issue":"1","key":"2025042109354821900_CIT0033","doi-asserted-by":"publisher","first-page":"E31","DOI":"10.1152\/ajpendo.00500.2006","article-title":"Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance","volume":"293","author":"Noland","year":"2007","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"8","key":"2025042109354821900_CIT0034","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1113\/jphysiol.2009.169060","article-title":"Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury","volume":"587","author":"Thyfault","year":"2009","journal-title":"J Physiol."},{"issue":"7","key":"2025042109354821900_CIT0035","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1053\/j.gastro.2006.03.019","article-title":"Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease","volume":"130","author":"Church","year":"2006","journal-title":"Gastroenterology."},{"issue":"14","key":"2025042109354821900_CIT0036","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1113\/JP274281","article-title":"Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis","volume":"595","author":"Morris","year":"2017","journal-title":"J Physiol."},{"issue":"5","key":"2025042109354821900_CIT0037","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/gerona\/glx208","article-title":"The relationship between physical activity and frailty among U.S. older adults based on hourly accelerometry data","volume":"73","author":"Huisingh-Scheetz","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci."}],"container-title":["The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/80\/5\/glaf021\/62960456\/glaf021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article-pdf\/80\/5\/glaf021\/62960456\/glaf021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T09:36:07Z","timestamp":1745228167000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biomedgerontology\/article\/doi\/10.1093\/gerona\/glaf021\/8116879"}},"subtitle":[],"editor":[{"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"(Biological Sciences Section)"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4,7]]}},"URL":"https:\/\/doi.org\/10.1093\/gerona\/glaf021","relation":{},"ISSN":["1079-5006","1758-535X"],"issn-type":[{"value":"1079-5006","type":"print"},{"value":"1758-535X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,7]]},"article-number":"glaf021"}}