{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:52:22Z","timestamp":1790110342834,"version":"4.0.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Top Talent Support Program"},{"name":"Wuxi Health Committee","award":["BJ2023045"],"award-info":[{"award-number":["BJ2023045"]}]},{"name":"Medical Technology Research Project"},{"DOI":"10.13039\/501100008109","name":"Wuxi Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20232017"],"award-info":[{"award-number":["Y20232017"]}],"id":[{"id":"10.13039\/501100008109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The pathophysiology of delirium remains incompletely understood. The relationship between preoperative plasma concentrations of p-tau181, p-tau231, p-tau217, and T-tau proteins and postoperative delirium (POD) needs further validation. We aimed to verify whether these markers can identify and predict the occurrence and severity of POD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>172 Older adults undergoing laparoscopic surgery were selected from a tertiary comprehensive hospital. All patients received intravenous anesthesia. Preoperative plasma concentrations of p-tau181, p-tau231, p-tau217, and T-tau proteins were measured using enzyme-linked immunosorbent assay. The occurrence and severity of POD were respectively assessed using the 3D-CAM and DRS-R-98 scales.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 172 patients (mean age: 72\u2005\u00b1\u20056 years, 34.9% female), 20 (12%) experienced POD. Patients who developed POD had higher preoperative plasma concentrations of p-tau181, p-tau231, p-tau217, and T-tau than those without. After adjusting for age, ASA, and education, preoperative concentrations of p-tau181 (OR 1.05, 95% CI: 1.03\u20131.08), p-tau217 (OR 1.02, 95% CI: 1.01\u20131.04), p-tau231 (OR 1.09, 95% CI: 1.04\u20131.14), and T-tau (OR 1.01, 95% CI: 1.00\u20131.02) were independently associated with POD (p&amp;lt;.001). Preoperative plasma p-tau231 showed the highest diagnostic performance with an area under the curve of 0.966, surpassing p-tau181 (0.869), p-tau217 (0.775), and T-tau (0.750). P-tau231 also demonstrated the highest sensitivity (0.900) and specificity (0.967) for predicting POD, compared to p-tau181, p-tau217, and T-tau.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Preoperative plasma concentrations of p-tau181, p-tau231, and p-tau217 can effectively predict the occurrence and severity of POD in older adult undergoing laparoscopic surgery, with p-tau231 demonstrating higher predictive value.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glaf058","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T23:50:51Z","timestamp":1744674651000},"source":"Crossref","is-referenced-by-count":4,"title":["Preoperative Plasma p-tau231, p-tau181, and p-tau217 Are Associated With Postoperative Delirium: A Prospective Study"],"prefix":"10.1093","volume":"80","author":[{"given":"LiXue","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangnan University , Wuxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaBao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangnan University , Wuxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuangLing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangnan University , Wuxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangnan University , Wuxi 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