{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:07:43Z","timestamp":1792112863344,"version":"4.4.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG050797, R01 AG057431, T32 AG021890"],"award-info":[{"award-number":["R01 AG050797, R01 AG057431, T32 AG021890"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX004167"],"award-info":[{"award-number":["I01 BX004167"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001325","name":"San Antonio Area Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001325","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Geriatric Research, Education and Clinical Center of the South Texas Veterans Health Care System"},{"name":"San Antonio Nathan Shock Center","award":["P30 AG013319"],"award-info":[{"award-number":["P30 AG013319"]}]},{"name":"San Antonio Older Americans Independence Center","award":["P30 AG044271"],"award-info":[{"award-number":["P30 AG044271"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Methionine restriction (MR) has many effects on different molecular and physiological systems and pathways associated with aging. However, these outcomes have often been ambiguous across studies, suggesting the context of outcomes, including tissue type or donor sex, may have a significant impact. We have previously shown that methionine sulfoxide reductase A (MsrA) may have discrete roles on aging physiology under MR. Here, we investigated the effect of MR on putative molecular hallmarks of aging, including mitochondrial function and regulation of the intracellular signal hydrogen sulfide, across tissues and in males and females. We found that females tended to have greater changes in mitochondrial oxygen consumption than males with MR, while the effects of MsrA were context-dependent. Mitochondrial hydrogen peroxide production was decreased by MR in hepatic mitochondria from females and only slightly higher with loss of MsrA in both sexes. In contrast, mitochondrial peroxide production was increased in the kidney with MR regardless of sex or MsrA status. Hydrogen sulfide production capacity was increased only in the liver by MR independent of MsrA, though expression of regulators of hydrogen sulfide generation was changed in a tissue-dependent manner that was not altered by MsrA status. Expression of methionine sulfoxide reductases was also impacted by MR, showing changes in expression in a tissue and sex-dependent manner. These results suggest a complex interaction between tissue, sex, diet, and MsrA status.<\/jats:p>","DOI":"10.1093\/gerona\/glaf177","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:14:47Z","timestamp":1755036887000},"source":"Crossref","is-referenced-by-count":2,"title":["Tissue-specific molecular regulation of aging mechanisms with methionine restriction in mice and the potential role of methionine sulfoxide reductase"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-0399","authenticated-orcid":false,"given":"Kevin M","family":"Thyne","sequence":"first","affiliation":[{"name":"Sam and Ann Barshop Institute for Longevity and Aging Studies and Departments of Molecular Medicine and Cellular and Integrative Physiology, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-5791","authenticated-orcid":false,"given":"Raechel","family":"Camones","sequence":"additional","affiliation":[{"name":"Sam and Ann Barshop Institute for Longevity and Aging Studies and Departments of Molecular Medicine and Cellular and Integrative Physiology, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-7843","authenticated-orcid":false,"given":"Adam B","family":"Salmon","sequence":"additional","affiliation":[{"name":"Sam and Ann Barshop Institute for Longevity and Aging Studies and Departments of Molecular Medicine and Cellular and Integrative Physiology, University of Texas Health San Antonio , San Antonio, TX,","place":["United States"]},{"name":"Geriatric Research Education and Clinical Center, Audie L. Murphy Hospital, South Texas Veterans Health Care System , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"2025101005103579000_glaf177-B1","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/gerona\/glp051","article-title":"Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age","volume":"64","author":"Sun","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"2025101005103579000_glaf177-B2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/MCO.0000000000000239","article-title":"The conserved role of protein restriction in aging and disease","volume":"19","author":"Mirzaei","year":"2016","journal-title":"Curr Opin Clin Nutr Metab 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