{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:50:46Z","timestamp":1772643046467,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JieBangGuaShuai Project of Liaoning Province","award":["2021JH1\/1040050"],"award-info":[{"award-number":["2021JH1\/1040050"]}]},{"name":"Young Elite Scientists Sponsorship Program by China Association for Science and Technology","award":["2020QNRC001"],"award-info":[{"award-number":["2020QNRC001"]}]},{"DOI":"10.13039\/501100018617","name":"LiaoNing Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2203168"],"award-info":[{"award-number":["XLYC2203168"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intrinsic capacity (IC), reflecting an individual\u2019s physical and mental capacities, is a core concept proposed by the World Health Organization (WHO) to promote healthy aging. This study aimed at examining the association between IC and chronic kidney disease (CKD) incidence and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 389 805 UK Biobank participants without baseline CKD. Functional decline was quantified using an IC deficit proxy score derived from eight biomarkers across five IC domains. A polygenic score (PGS) for estimated glomerular filtration rate (eGFR) was also calculated. Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CKD, and two-sample Mendelian randomization (MR) was conducted to explore potential causal relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A one-point increment in the IC deficit proxy score was associated with a higher risk of developing CKD (HR\u2009=\u20091.16, 95% CI, 1.14, 1.18; P-trend &amp;lt; .0001), independent of genetic susceptibility to eGFR. The highest risk of CKD was observed among individuals with a high IC deficit and low genetically predicted eGFR (HR\u2009=\u20091.88, 95% CI, 1.72\u20132.06). MR analysis supported a causal relationship between faster walking pace and lower CKD risk. Among individuals with CKD, a higher IC deficit proxy score (3+) was linked to reduced life expectancy at age 45 years (1.09 years lost in life expectancy; 95% CI, 0.68\u20131.51).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IC decline was independently associated with increased CKD risk and with further reductions in life expectancy. Enhancing IC may be a viable strategy for CKD prevention and healthy aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glaf187","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:14:17Z","timestamp":1760616857000},"source":"Crossref","is-referenced-by-count":1,"title":["Associations of intrinsic capacity deficit proxy score and genetic susceptibility with incident chronic kidney disease and life expectancy"],"prefix":"10.1093","volume":"80","author":[{"given":"Gang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengrong","family":"Ou","sequence":"additional","affiliation":[{"name":"School of Public Health, China Medical University , Shenyang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxian","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-658X","authenticated-orcid":false,"given":"Difei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , 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